Targeting coagulation factor receptors - protease-activated receptors in idiopathic pulmonary fibrosis

Membrane-anchored Serine Protease Matriptase Is a Trigger of Pulmonary Fibrogenesis

(2016) Olivier Bardou et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting Liver Fibrosis with a Cell-penetrating Protease-activated Receptor-2 (PAR2) Pepducin

(2016) Andrew M. Shearer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High endogenous activated protein C levels attenuates bleomycin-induced pulmonary fibrosis

(2016) Cong Lin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Protein S is protective in pulmonary fibrosis

(2016) M. Urawa et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Increased Mortality during Bleomycin-induced Pulmonary Fibrosis due to Low Endogenous Activated Protein C Levels

(2015) Cong Lin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nintedanib and Pirfenidone. New Antifibrotic Treatments Indicated for Idiopathic Pulmonary Fibrosis Offer Hopes and Raises Questions

(2015) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Recombinant Human Thrombomodulin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis

(2015) Kensuke Kataoka et al.   CHEST

Role of proteinase-activated receptor-1 gene polymorphisms in susceptibility to chronic obstructive pulmonary disease

(2015) C.M. Yun et al.   GENETICS AND MOLECULAR RESEARCH

Heparan Sulfate Proteoglycans Mediate Factor XIIa Binding to the Cell Surface

(2015) Lukasz Wujak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

(2015) Cong Lin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Regulation of Neutrophilic Inflammation by Proteinase-Activated Receptor 1 during Bacterial Pulmonary Infection

(2015) Ricardo J. José et al.   JOURNAL OF IMMUNOLOGY

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(2015) Cong Lin et al.   MOLECULAR MEDICINE

Role of a functional polymorphism in theF2Rgene promoter in sarcoidosis

(2015) Manuela Platé et al.   RESPIROLOGY

A Brief Exposure to Tryptase or Thrombin Potentiates Fibrocyte Differentiation in the Presence of Serum or Serum Amyloid P

(2014) Michael J. V. White et al.   JOURNAL OF IMMUNOLOGY

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

(2014) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Idiopathic Pulmonary Fibrosis: From Epithelial Injury to Biomarkers - Insights from the Bench Side

(2014) Keren Borensztajn et al.   RESPIRATION

Combination therapy: the future of management for idiopathic pulmonary fibrosis?

(2014) Wim A Wuyts et al.   Lancet Respiratory Medicine

Thrombin induces epithelial-mesenchymal transition via PAR-1, PKC, and ERK1/2 pathways in A549 cells

(2013) Jeong Sup Song et al.   EXPERIMENTAL LUNG RESEARCH

Protease-activated receptor-2 deficient mice have reduced house dust mite-evoked allergic lung inflammation

(2013) J Daan de Boer et al.   Innate Immunity

Novel Role for p21-activated Kinase 2 in Thrombin-induced Monocyte Migration

(2013) Ravisekhar Gadepalli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteinase-activated Receptor-2 Transactivation of Epidermal Growth Factor Receptor and Transforming Growth Factor-β Receptor Signaling Pathways Contributes to Renal Fibrosis

(2013) Hyunjae Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protease-Activated Receptor 1 Inhibition by SCH79797 Attenuates Left Ventricular Remodeling and Profibrotic Activities of Cardiac Fibroblasts

(2013) Dmitry L. Sonin et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Protease Activated Receptor-2 Contributes to Heart Failure

(2013) Silvio Antoniak et al.   PLoS One

Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case–control study

(2013) Vidya Navaratnam et al.   THORAX

Targeting protease activated receptor-1 with P1pal-12 limits bleomycin-induced pulmonary fibrosis

(2013) Cong Lin et al.   THORAX

Protease-activated receptors (PAR)-1 and -3 drive epithelial-mesenchymal transition of alveolar epithelial cells – potential role in lung fibrosis

(2013) Miroslava Didiasova et al.   THROMBOSIS AND HAEMOSTASIS

Targeting factor Xa and thrombin: impact on coagulation and beyond

(2013) Charles T. Esmon   THROMBOSIS AND HAEMOSTASIS

Idiopathic pulmonary fibrosis

(2013) O. J. Dempsey et al.   BMJ-British Medical Journal

Pharmacological inhibition of PAR2 with the pepducin P2pal-18S protects mice against acute experimental biliary pancreatitis

(2012) E. S. Michael et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A Placebo-Controlled Randomized Trial of Warfarin in Idiopathic Pulmonary Fibrosis

(2012) Imre Noth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Impact on Inflammation and Recovery of Skin Barrier by Nordihydroguaiaretic Acid as a Protease-Activated Receptor 2 Antagonist

(2012) Hyo-Young Kim et al.   Biomolecules & Therapeutics

PAR-2 Inhibition Reverses Experimental Pulmonary Hypertension

(2012) Grazyna Kwapiszewska et al.   CIRCULATION RESEARCH

An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats

(2012) Rink-Jan Lohman et al.   FASEB JOURNAL

Inhibition of Protease-activated Receptor 1 Ameliorates Intestinal Radiation Mucositis in a Preclinical Rat Model

(2012) Junru Wang et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Targeting proteinase-activated receptors: therapeutic potential and challenges

(2012) Rithwik Ramachandran et al.   NATURE REVIEWS DRUG DISCOVERY

PAR-1 antagonist SCH79797 ameliorates apoptosis following surgical brain injury through inhibition of ASK1-JNK in rats

(2012) Anatol Manaenko et al.   NEUROBIOLOGY OF DISEASE

Granzyme B-Induced Neurotoxicity Is Mediated via Activation of PAR-1 Receptor and Kv1.3 Channel

(2012) Tongguang Wang et al.   PLoS One

Inhibition of Proinflammatory Cytokines by SCH79797, a Selective Protease-Activated Receptor 1 Antagonist, Protects Rat Kidney Against Ischemia-Reperfusion Injury

(2012) Eman Abdelazeem El Eter et al.   SHOCK

Serine Protease Inhibition Reduces Post-Ischemic Granulocyte Recruitment in Mouse Intestine

(2011) Thomas Gobbetti et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of Protease-activated Receptor-2 in Idiopathic Pulmonary Fibrosis

(2011) Malgorzata Wygrecka et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Protease-Activated Receptor-2 Modulates Protease-Activated Receptor-1–Driven Neointimal Hyperplasia

(2011) Leila M. Sevigny et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis

(2011) Sarah L. Tressel et al.   EMBO Molecular Medicine

Protease-activated receptor 2 promotes experimental liver fibrosis in mice and activates human hepatic stellate cells

(2011) Virginia Knight et al.   HEPATOLOGY

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Telomerase and idiopathic pulmonary fibrosis

(2011) Mary Armanios   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The rising incidence of idiopathic pulmonary fibrosis in the UK

(2011) V. Navaratnam et al.   THORAX

Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice

(2011) Virginie Rabolli et al.   TOXICOLOGY LETTERS

Protease-Activated Receptor-2 Induces Myofibroblast Differentiation and Tissue Factor Up-Regulation during Bleomycin-Induced Lung Injury

(2010) Keren Borensztajn et al.   AMERICAN JOURNAL OF PATHOLOGY

Safety and Tolerability of Inhaled Heparin in Idiopathic Pulmonary Fibrosis

(2010) Philipp Markart et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

New Mechanisms of Pulmonary Fibrosis

(2009) Robert M. Strieter et al.   CHEST

Factor Xa Stimulates Proinflammatory and Profibrotic Responses in Fibroblasts via Protease-Activated Receptor-2 Activation

(2008) Keren Borensztajn et al.   AMERICAN JOURNAL OF PATHOLOGY

Effect of a thrombin receptor (protease-activated receptor 1,PAR-1) gene polymorphism in chronic hepatitis C liver fibrosis

(2007) Ana Martinelli et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY