Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

Protease-activated-receptor-2 affects protease-activated-receptor-1-driven breast cancer

(2013) Mohammad Jaber et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transactivation of the PAR1-PAR2 Heterodimer by Thrombin Elicits β-Arrestin-mediated Endosomal Signaling

(2013) Huilan Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bleomycin Induces Molecular Changes Directly Relevant to Idiopathic Pulmonary Fibrosis: A Model for “Active” Disease

(2013) Ruoqi Peng et al.   PLoS One

Targeting protease activated receptor-1 with P1pal-12 limits bleomycin-induced pulmonary fibrosis

(2013) Cong Lin et al.   THORAX

Matrix metalloproteases and PAR1 activation

(2012) K. M. Austin et al.   BLOOD

Protease-activated receptor-4 deficiency does not protect against bleomycin-induced pulmonary fibrosis in mice: Figure 1–

(2012) Keren Borensztajn et al.   EUROPEAN RESPIRATORY JOURNAL

Targeting proteinase-activated receptors: therapeutic potential and challenges

(2012) Rithwik Ramachandran et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

CCAAT/enhancer-binding protein   facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner

(2012) J. Duitman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical implication of protease-activated receptor-2 in idiopathic pulmonary fibrosis

(2012) Young Sik Park et al.   RESPIRATORY MEDICINE

Role of Protease-activated Receptor-2 in Idiopathic Pulmonary Fibrosis

(2011) Malgorzata Wygrecka et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Progress Toward Improving Animal Models for Idiopathic Pulmonary Fibrosis

(2011) Amber L. Degryse et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Protease-Activated Receptor-2 Modulates Protease-Activated Receptor-1–Driven Neointimal Hyperplasia

(2011) Leila M. Sevigny et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pirfenidone

(2011) Natalie J. Carter   DRUGS

A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis

(2011) Sarah L. Tressel et al.   EMBO Molecular Medicine

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins

(2011) L. M. Sevigny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through  -arrestin and dishevelled-2 scaffolds

(2011) U. J. K. Soh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protease-Activated Receptor-2 Induces Myofibroblast Differentiation and Tissue Factor Up-Regulation during Bleomycin-Induced Lung Injury

(2010) Keren Borensztajn et al.   AMERICAN JOURNAL OF PATHOLOGY

Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis

(2010) Amber L. Degryse et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Protease-activated receptors mediate crosstalk between coagulation and fibrinolysis

(2010) T. A. McEachron et al.   BLOOD

Signal transduction by protease-activated receptors

(2010) Unice JK Soh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Strategies for treating idiopathic pulmonary fibrosis

(2010) R. M. du Bois   NATURE REVIEWS DRUG DISCOVERY

Factor Xa Stimulates Proinflammatory and Profibrotic Responses in Fibroblasts via Protease-Activated Receptor-2 Activation

(2008) Keren Borensztajn et al.   AMERICAN JOURNAL OF PATHOLOGY