Targeting Liver Fibrosis with a Cell-penetrating Protease-activated Receptor-2 (PAR2) Pepducin

Cancer therapy in the necroptosis era

(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

Pathogenesis of Nonalcoholic Steatohepatitis

(2016) Mariana Verdelho Machado et al.   GASTROENTEROLOGY

Reversal of murine alcoholic steatohepatitis by pepducin-based functional blockade of interleukin-8 receptors

(2016) Verena Wieser et al.   GUT

Cell-Penetrating Pepducin Therapy Targeting PAR1 in Subjects With Coronary Artery Disease

(2015) Paul A. Gurbel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

Tissue factor pathways linking obesity and inflammation

(2015) W. Ruf et al.   Hamostaseologie

Allosteric Activation of a G Protein-coupled Receptor with Cell-penetrating Receptor Mimetics

(2015) Ping Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibrosis — A Common Pathway to Organ Injury and Failure

(2015) Don C. Rockey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Codistribution of Collagen Type IV and Laminin in Liver Fibrosis of Elderly Cadavers: Immunohistochemical Marker of Perisinusoidal Basement Membrane Formation

(2014) Ki M. Mak et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Circulating microparticle tissue factor activity Is increased in patients with cirrhosis

(2014) Pierre-Emmanuel Rautou et al.   HEPATOLOGY

Hepatocyte tissue factor activates the coagulation cascade in mice

(2013) B. P. Sullivan et al.   BLOOD

Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease

(2013) M D Hollenberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease

(2013) Karima Begriche et al.   HEPATOLOGY

Proteinase-activated Receptor-2 Transactivation of Epidermal Growth Factor Receptor and Transforming Growth Factor-β Receptor Signaling Pathways Contributes to Renal Fibrosis

(2013) Hyunjae Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolving therapies for liver fibrosis

(2013) Detlef Schuppan et al.   JOURNAL OF CLINICAL INVESTIGATION

FRET-based imaging of transbilayer movement of pepducin in living cells by novel intracellular bioreductively activatable fluorescent probes

(2013) Mieko Tsuji et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein

(2013) J. Quoyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

Pharmacological inhibition of PAR2 with the pepducin P2pal-18S protects mice against acute experimental biliary pancreatitis

(2012) E. S. Michael et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Suppression of Arterial Thrombosis Without Affecting Hemostatic Parameters With a Cell-Penetrating PAR1 Pepducin

(2012) Ping Zhang et al.   CIRCULATION

Turning Receptors On and Off with Intracellular Pepducins: New Insights into G-protein-coupled Receptor Drug Development

(2012) Katie O'Callaghan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation and fibrogenesis in steatohepatitis

(2012) Hideki Fujii et al.   JOURNAL OF GASTROENTEROLOGY

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Protease-activated Receptor-2 in Idiopathic Pulmonary Fibrosis

(2011) Malgorzata Wygrecka et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Protease-Activated Receptor-2 Modulates Protease-Activated Receptor-1–Driven Neointimal Hyperplasia

(2011) Leila M. Sevigny et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protease-activated receptor 2 promotes experimental liver fibrosis in mice and activates human hepatic stellate cells

(2011) Virginia Knight et al.   HEPATOLOGY

Crystallographic Analysis of the Primary Photochemical Reaction of Squid Rhodopsin

(2011) Midori Murakami et al.   JOURNAL OF MOLECULAR BIOLOGY

Vitamin A and lipid metabolism: relationship between hepatic stellate cells (HSCs) and adipocytes

(2011) Patrick Sauvant et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Tissue factor–protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation

(2011) Leylla Badeanlou et al.   NATURE MEDICINE

Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins

(2011) L. M. Sevigny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protease-Activated Receptor-2 Induces Myofibroblast Differentiation and Tissue Factor Up-Regulation during Bleomycin-Induced Lung Injury

(2010) Keren Borensztajn et al.   AMERICAN JOURNAL OF PATHOLOGY

Platelet Matrix Metalloprotease-1 Mediates Thrombogenesis by Activating PAR1 at a Cryptic Ligand Site

(2009) Vishal Trivedi et al.   CELL

Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim

(2009) Thomas Kaufmann et al.   IMMUNITY

The coagulation factor Xa/protease activated receptor-2 axis in the progression of liver fibrosis: a multifaceted paradigm

(2009) Keren Borensztajn et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Crystal Structure of Squid Rhodopsin with Intracellularly Extended Cytoplasmic Region

(2008) Tatsuro Shimamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY