Deciphering the roles of FOXO1 in human neoplasms

FOXO1/3: Potential suppressors of fibrosis

(2018) Zhenlong Xin et al.   AGEING RESEARCH REVIEWS

Melatonin protects diabetic heart against ischemia-reperfusion injury, role of membrane receptor-dependent cGMP-PKG activation

(2018) Li-ming Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Snapshots: Endoplasmic Reticulum Stress in Lipid Metabolism and Cardiovascular Disease

(2018) Tian Li et al.   CURRENT ISSUES IN MOLECULAR BIOLOGY

Understanding the role of mammalian sterile 20-like kinase 1 (MST1) in cardiovascular disorders

(2018) Yang Yang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Targeting Gas6/TAM in cancer cells and tumor microenvironment

(2018) Guiling Wu et al.   Molecular Cancer

Mechanisms controlling the anti-neoplastic functions of FoxO proteins

(2018) Tianyun Hou et al.   SEMINARS IN CANCER BIOLOGY

FOXO1: Another avenue for treating digestive malignancy?

(2018) Feiyu Shi et al.   SEMINARS IN CANCER BIOLOGY

FoxO transcription factors in cancer metabolism

(2018) Raj Kumar Yadav et al.   SEMINARS IN CANCER BIOLOGY

FOXOs in cancer immunity: Knowns and unknowns

(2018) Youcai Deng et al.   SEMINARS IN CANCER BIOLOGY

FOXO1 down-regulation is associated with worse outcome in bladder cancer and adds significant prognostic information to p53 overexpression

(2017) Josep Lloreta et al.   HUMAN PATHOLOGY

PAX3-FOXO1 is essential for tumour initiation and maintenance but not recurrence in a human myoblast model of rhabdomyosarcoma

(2017) Puspa R Pandey et al.   JOURNAL OF PATHOLOGY

Melatonin: A pleiotropic molecule that modulates DNA damage response and repair pathways

(2017) Maryam Majidinia et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis

(2017) Mengen Zhai et al.   JOURNAL OF PINEAL RESEARCH

Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type–Specific Differences

(2017) Yasin Kaymaz et al.   MOLECULAR CANCER RESEARCH

IGF-1 Receptor Modulates FoxO1-Mediated Tamoxifen Response in Breast Cancer Cells

(2017) Ali Vaziri-Gohar et al.   MOLECULAR CANCER RESEARCH

Role of STAT3 and FOXO1 in the Divergent Therapeutic Responses of Non-metastatic and Metastatic Bladder Cancer Cells to miR-145

(2017) Guosong Jiang et al.   MOLECULAR CANCER THERAPEUTICS

MicroRNA-142-5p Overexpression Inhibits Cell Growth and Induces Apoptosis by Regulating FOXO in Hepatocellular Carcinoma Cells

(2017) Kexin Lou et al.   ONCOLOGY RESEARCH

Curcumin as a potential protective compound against cardiac diseases

(2017) Shuai Jiang et al.   PHARMACOLOGICAL RESEARCH

A global perspective on FOXO1 in lipid metabolism and lipid-related diseases

(2017) Yue Li et al.   PROGRESS IN LIPID RESEARCH

Laminins and cancer stem cells: Partners in crime?

(2017) Yan Qin et al.   SEMINARS IN CANCER BIOLOGY

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development

(2017) Zhen-Dong Xiao et al.   Nature Communications

Transcription factor HBP1 is a direct anti-cancer target of transcription factor FOXO1 in invasive oral cancer

(2017) Chien-Yi Chan et al.   Oncotarget

FOXC1 in cancer development and therapy: deciphering its emerging and divergent roles

(2017) Zhi Yang et al.   Therapeutic Advances in Medical Oncology

Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis

(2017) Shiri Procaccia et al.   Scientific Reports

Pterostilbene exerts anticancer activity on non-small-cell lung cancer via activating endoplasmic reticulum stress

(2017) Zhiqiang Ma et al.   Scientific Reports

Regenerative function of immune system: Modulation of muscle stem cells

(2016) Jasdeep Saini et al.   AGEING RESEARCH REVIEWS

Targeting the energy guardian AMPK: another avenue for treating cardiomyopathy?

(2016) Tian Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

An overview of the mechanisms and novel roles of Nrf2 in cardiovascular diseases

(2016) Shuai Jiang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Screening for Colorectal Cancer and Evolving Issues for Physicians and Patients

(2016) David Lieberman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC and can be targeted by SYK inhibition

(2016) S Köhrer et al.   LEUKEMIA

Fat and the fate of pancreatic tumours

(2016) Melek Canan Arkan   NATURE

Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity

(2016) Chong T. Luo et al.   NATURE

Rapid decay of engulfed extracellular miRNA by XRN1 exonuclease promotes transient epithelial-mesenchymal transition

(2016) Joséphine Zangari et al.   NUCLEIC ACIDS RESEARCH

FOXO1 is a TXN- and p300-dependent sensor and effector of oxidative stress in diffuse large B-cell lymphomas characterized by increased oxidative metabolism

(2016) T Sewastianik et al.   ONCOGENE

Toll-like receptors signaling: A complex network for NF-κB activation in B-cell lymphoid malignancies

(2016) Stavroula Ntoufa et al.   SEMINARS IN CANCER BIOLOGY

DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation

(2016) Emil Mladenov et al.   SEMINARS IN CANCER BIOLOGY

Bioactive natural products for chemoprevention and treatment of castration-resistant prostate cancer

(2016) Georgios Kallifatidis et al.   SEMINARS IN CANCER BIOLOGY

Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis

(2016) Jinho Heo et al.   SEMINARS IN CANCER BIOLOGY

Involvement of F-BOX proteins in progression and development of human malignancies

(2016) Shahab Uddin et al.   SEMINARS IN CANCER BIOLOGY

Forkhead Transcription Factor FOXO1 Inhibits Angiogenesis in Gastric Cancer in Relation to SIRT1

(2016) Sue Youn Kim et al.   Cancer Research and Treatment

Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1

(2016) Tamás Fodor et al.   PLoS One

Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling

(2016) Bastien Cautain et al.   PLoS One

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling

(2015) Bettina C Urban et al.   GUT

Long-term exposure to leptin enhances the growth of prostate cancer cells

(2015) TERUTAKA NODA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

β-Arrestin2 Contributes to Cell Viability and Proliferation via the Down-Regulation of FOXO1 in Castration-Resistant Prostate Cancer

(2015) Xiaolu Duan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression

(2015) Thaiz Ferraz Borin et al.   JOURNAL OF PINEAL RESEARCH

FoxO1-dependent induction of acute myeloid leukemia by osteoblasts in mice

(2015) A Kode et al.   LEUKEMIA

Dissecting chronic lymphocytic leukemia microenvironment signals in patients with unmutated disease: microRNA-22 regulates phosphatase and tensin homolog/AKT/FOXO1 pathway in proliferative leukemic cells

(2015) Florencia Palacios et al.   LEUKEMIA & LYMPHOMA

Curcumin induces apoptosis in pancreatic cancer cells through the induction of forkhead box O1 and inhibition of the PI3K/Akt pathway

(2015) ZHIMING ZHAO et al.   Molecular Medicine Reports

Expression and regulation of COP1 in chronic lymphocytic leukemia cells for promotion of cell proliferation and tumorigenicity

(2015) CHUNLING FU et al.   ONCOLOGY REPORTS

Therapy escape mechanisms in the malignant prostate

(2015) Frédéric R. Santer et al.   SEMINARS IN CANCER BIOLOGY

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

(2015) Mark A. Feitelson et al.   SEMINARS IN CANCER BIOLOGY

Broad targeting of resistance to apoptosis in cancer

(2015) Ramzi M. Mohammad et al.   SEMINARS IN CANCER BIOLOGY

Insulin-like growth factor 1 promotes growth of gastric cancer by inhibiting foxo1 nuclear retention

(2015) Shuangling Li et al.   TUMOR BIOLOGY

Posttranslational modifications of FOXO1 regulate epidermal growth factor receptor tyrosine kinase inhibitor resistance for non-small cell lung cancer cells

(2015) Zhi-hong Xu et al.   TUMOR BIOLOGY

MicroRNA-21 plays an oncogenic role by targeting FOXO1 and activating the PI3K/AKT pathway in diffuse large B-cell lymphoma

(2015) Heounjeong Go et al.   Oncotarget

FOXO1 downregulation contributes to the oncogenic program of primary mediastinal B-cell lymphoma

(2015) Linka Xie et al.   Oncotarget

Inhibition of Cyclin-Dependent Kinase Phosphorylation of FOXO1 and Prostate Cancer Cell Growth by a Peptide Derived from FOXO1

(2015) Huarui Lu et al.   NEOPLASIA

Forkhead transcription factor FOXO1 inhibits nuclear factor-κB in gastric cancer

(2014) Da-Ae Yu et al.   APMIS

FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT Pathway

(2014) Aifu Lin et al.   CANCER RESEARCH

Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition

(2014) Yoav D. Shaul et al.   CELL

FOXO1 3′UTR functions as a ceRNA in repressing the metastases of breast cancer cells via regulating miRNA activity

(2014) Jue Yang et al.   FEBS LETTERS

MHY-449, a novel dihydrobenzofuro[4,5-b][1,8] naphthyridin-6-one derivative, induces apoptotic cell death through modulation of Akt/FoxO1 and ERK signaling in PC3 human prostate cancer cells

(2014) SUN HWA LEE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor

(2014) Xi Wang et al.   Molecular Cancer

Bladder cancers arise from distinct urothelial sub-populations

(2014) Jason Van Batavia et al.   NATURE CELL BIOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Post-transcriptional repression of FOXO1 by QKI results in low levels of FOXO1 expression in breast cancer cells

(2014) FANG YU et al.   ONCOLOGY REPORTS

Targeting forkhead box transcription factors FOXM1 and FOXO in leukemia (Review)

(2014) HONG ZHU   ONCOLOGY REPORTS

FOXM1: A key oncofoetal transcription factor in health and disease

(2014) Laura Bella et al.   SEMINARS IN CANCER BIOLOGY

The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors

(2014) Francesca Pellicano et al.   STEM CELLS

Analysis of FOXO1 mutations in diffuse large B-cell lymphoma

(2013) D. L. Trinh et al.   BLOOD

SIRT1-Mediated FoxO1 Deacetylation Is Essential for Multidrug Resistance-Associated Protein 2 Expression in Tamoxifen-Resistant Breast Cancer Cells

(2013) Hoo-Kyun Choi et al.   MOLECULAR PHARMACEUTICS

The FoxO–BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress

(2013) A Lin et al.   ONCOGENE

FOXO1 is a tumor suppressor in classical Hodgkin lymphoma

(2012) L. Xie et al.   BLOOD

Overexpression of GOLPH3 Promotes Proliferation and Tumorigenicity in Breast Cancer via Suppression of the FOXO1 Transcription Factor

(2012) Z. Zeng et al.   CLINICAL CANCER RESEARCH

Helicobacter pylori-Associated Regulation of Forkhead Transcription Factors FoxO1/3a in Human Gastric Cells

(2012) Fazal H. Tabassam et al.   HELICOBACTER

Upregulation of MircoRNA-370 Induces Proliferation in Human Prostate Cancer Cells by Downregulating the Transcription Factor FOXO1

(2012) Ziqing Wu et al.   PLoS One

Constitutive phosphorylation of the FOXO1 transcription factor in gastric cancer cells correlates with microvessel area and the expressions of angiogenesis-related molecules

(2011) Sue Youn Kim et al.   BMC CANCER

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

FOXO1 Inhibits Runx2 Transcriptional Activity and Prostate Cancer Cell Migration and Invasion

(2011) H. Zhang et al.   CANCER RESEARCH

Pancreatic Tumor Suppression by Benzyl Isothiocyanate Is Associated with Inhibition of PI3K/AKT/FOXO Pathway

(2011) S. R. Boreddy et al.   CLINICAL CANCER RESEARCH

Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism

(2011) Gabriel Frampton et al.   GUT

Curcumin potentiates antitumor activity ofl-asparaginase via inhibition of the AKT signaling pathway in acute lymphoblastic leukemia

(2011) Hua Wang et al.   LEUKEMIA & LYMPHOMA

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

(2011) Ryan D. Morin et al.   NATURE

Analysis of the coding genome of diffuse large B-cell lymphoma

(2011) Laura Pasqualucci et al.   NATURE GENETICS

FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis

(2010) Boyi Gan et al.   CANCER CELL

Amurensin G, a Potent Natural SIRT1 Inhibitor, Rescues Doxorubicin Responsiveness via Down-Regulation of Multidrug Resistance 1

(2010) W. K. Oh et al.   MOLECULAR PHARMACOLOGY

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

Coordinate Regulation of FOXO1 by miR-27a, miR-96, and miR-182 in Breast Cancer Cells

(2009) Irene K. Guttilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of dephosphorylation of FOXO1 on apoptosis induced by wortmannin for non-Hodgkin’s lymphoma cells

(2009) Zhan Qiong et al.   MOLECULAR BIOLOGY REPORTS

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor

(2009) Yann M Kerdiles et al.   NATURE IMMUNOLOGY

Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

(2008) Hart S Dengler et al.   NATURE IMMUNOLOGY