Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling

Synthesis and Intracellular Redox Cycling of Natural Quinones and Their Analogues and Identification of Indoleamine-2,3-dioxygenase (IDO) as Potential Target for Anticancer Activity

(2015) Christopher E. Blunt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Special Review

(2015) Bibiana I. Ferreira et al.   CANCER JOURNAL

Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI’s provocative questions

(2015) Mikhail V. Blagosklonny   Oncotarget

Discovery of 14-3-3 Protein-Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693

(2014) Mattia Mori et al.   ChemMedChem

A novel cyclometallated Pt(ii)–ferrocene complex induces nuclear FOXO3a localization and apoptosis and synergizes with cisplatin to inhibit lung cancer cell proliferation

(2014) Roldán Cortés et al.   Metallomics

FOXO transcription factors: key regulators of cellular quality control

(2014) Ashley E. Webb et al.   TRENDS IN BIOCHEMICAL SCIENCES

NAD(P)H Quinone Oxidoreductase 1 (NQO1)-Bioactivated Pronqodine A Regulates Prostaglandin Release from Human Synovial Sarcoma Cells

(2013) Koichi Nakae et al.   JOURNAL OF NATURAL PRODUCTS

FOXOs: signalling integrators for homeostasis maintenance

(2013) Astrid Eijkelenboom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biological characterization of ETP-46321 a selective and efficacious inhibitor of phosphoinositide-3-kinases

(2012) Teresa G. Granda et al.   INVESTIGATIONAL NEW DRUGS

Objective assessment of cancer genes for drug discovery

(2012) Mishal N. Patel et al.   NATURE REVIEWS DRUG DISCOVERY

Moving to the Core: Spatiotemporal Analysis of Forkhead Box O (FOXO) and Nuclear Factor-κB (NF-κB) Nuclear Translocation

(2012) Fabian Zanella et al.   TRAFFIC

Cdc25A Regulates Matrix Metalloprotease 1 through Foxo1 and Mediates Metastasis of Breast Cancer Cells

(2011) X. Feng et al.   MOLECULAR AND CELLULAR BIOLOGY

Understanding FOXO, New Views on Old Transcription Factors

(2010) F. Zanella et al.   CURRENT CANCER DRUG TARGETS

High content screening: seeing is believing

(2010) Fabian Zanella et al.   TRENDS IN BIOTECHNOLOGY

Using multiplexed regulation of luciferase activity and GFP translocation to screen for FOXO modulators

(2009) Fabian Zanella et al.   BMC CELL BIOLOGY

Chemical Interrogation of FOXO3a Nuclear Translocation Identifies Potent and Selective Inhibitors of Phosphoinositide 3-Kinases

(2009) Wolfgang Link et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Genetic Analysis of FOXO Nuclear-Cytoplasmic Shuttling by Using Image-Based Cell Screening

(2008) Fabian Zanella et al.   CHEMBIOCHEM

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unravelling the tumor-suppressive functions of FOXO proteins

(2008) Tobias B. Dansen et al.   TRENDS IN CELL BIOLOGY