Targeting the energy guardian AMPK: another avenue for treating cardiomyopathy?

AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation

(2016) Evangelos P. Daskalopoulos et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia

(2016) Vlad G. Zaha et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Melatonin reverses flow shear stress-induced injury in bone marrow mesenchymal stem cells via activation of AMP-activated protein kinase signaling

(2016) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

Possible Role of Interaction between PPARαand Cyclophilin D in Cardioprotection of AMPK againstIn VivoIschemia-Reperfusion in Rats

(2016) Giselle Barreto-Torres et al.   PPAR Research

Risk of Bias in Systematic Reviews of Non-Randomized Studies of Adverse Cardiovascular Effects of Thiazolidinediones and Cyclooxygenase-2 Inhibitors: Application of a New Cochrane Risk of Bias Tool

(2016) Anja Bilandzic et al.   PLOS MEDICINE

The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARα-cyclophilin D interaction in cardiomyocytes

(2015) Giselle Barreto-Torres et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Therapeutic potential of resveratrol in heart failure

(2015) Miranda M. Sung et al.   Annals of the New York Academy of Sciences

Beyond Energy Homeostasis: the Expanding Role of AMP-Activated Protein Kinase in Regulating Metabolism

(2015) David Carling et al.   Cell Metabolism

Heart Disease and Stroke Statistics—2016 Update

(2015) Dariush Mozaffarian et al.   CIRCULATION

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

(2015) D Grahame Hardie   CURRENT OPINION IN CELL BIOLOGY

The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1–p70S6K–RPS6 signaling

(2015) Timothy D. Calamaras et al.   FREE RADICAL BIOLOGY AND MEDICINE

CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation

(2015) Dan Wu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Left ventricular non-compaction cardiomyopathy

(2015) Jeffrey A Towbin et al.   LANCET

Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015)   LANCET

Metformin activates a duodenal Ampk–dependent pathway to lower hepatic glucose production in rats

(2015) Frank A Duca et al.   NATURE MEDICINE

Overnourishment during lactation induces metabolic and haemodynamic heart impairment during adulthood

(2015) A.K.G. Vieira et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Exercise training prevents the attenuation of anesthetic pre-conditioning-mediated cardioprotection in diet-induced obese rats

(2014) L. LI et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Retinoid X Receptor Agonists Inhibit Hypertension-Induced Myocardial Hypertrophy by Modulating LKB1/AMPK/p70S6K Signaling Pathway

(2014) Jiang Zhu et al.   AMERICAN JOURNAL OF HYPERTENSION

A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake

(2014) Aurélie D. Timmermans et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

(2014) Simon A. Hawley et al.   BIOCHEMICAL JOURNAL

Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling

(2014) John W. Scott et al.   CHEMISTRY & BIOLOGY

Myostatin Regulates Energy Homeostasis in the Heart and Prevents Heart Failure

(2014) Nadine Biesemann et al.   CIRCULATION RESEARCH

Mutation in the γ2-Subunit of AMP-Activated Protein Kinase Stimulates Cardiomyocyte Proliferation and Hypertrophy Independent of Glycogen Storage

(2014) Maengjo Kim et al.   CIRCULATION RESEARCH

Aerobic interval training protects against myocardial infarction-induced oxidative injury by enhancing antioxidase system and mitochondrial biosynthesis

(2014) Hong-Ke Jiang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Metabolic crosstalk between the heart and liver impacts familial hypertrophic cardiomyopathy

(2014) J. A. Magida et al.   EMBO Molecular Medicine

Myocardial infarction in a teenager

(2014) E. B. Sternick et al.   EUROPEAN HEART JOURNAL

Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria

(2014) Jessica Soto Hernández et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

AdipoR1/APPL1 Potentiates the Protective Effects of Globular Adiponectin on Angiotensin II-Induced Cardiac Hypertrophy and Fibrosis in Neonatal Rat Atrial Myocytes and Fibroblasts

(2014) Tengwei Cao et al.   PLoS One

AMPK attenuates microtubule proliferation in cardiac hypertrophy

(2013) John T. Fassett et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Adiponectin knockout accentuates high fat diet-induced obesity and cardiac dysfunction: Role of autophagy

(2013) Rui Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

17-β Oestradiol prevents cardiovascular dysfunction in post-menopausal metabolic syndrome by affecting SIRT1/AMPK/H3 acetylation

(2013) Dhaval Sharad Bendale et al.   BRITISH JOURNAL OF PHARMACOLOGY

C1q/Tumor Necrosis Factor-Related Protein-9, a Novel Adipocyte-Derived Cytokine, Attenuates Adverse Remodeling in the Ischemic Mouse Heart via Protein Kinase A Activation

(2013) Y. Sun et al.   CIRCULATION

ULK1 Plays a Critical Role in AMPK-Mediated Myocardial Autophagy and Contractile Dysfunction following Acute Alcohol Challenge

(2013) Machender Kandadi et al.   CURRENT PHARMACEUTICAL DESIGN

Testosterone increases GLUT4-dependent glucose uptake in cardiomyocytes

(2013) Carlos Wilson et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Conserved regulatory elements in AMPK

(2013) Lei Chen et al.   NATURE

3,3′-Diindolylmethane Protects against Cardiac Hypertrophy via 5′-Adenosine Monophosphate-Activated Protein Kinase-α2

(2013) Jing Zong et al.   PLoS One

Identification of a Novel De Novo Mutation Associated with PRKAG2 Cardiac Syndrome and Early Onset of Heart Failure

(2013) Yang Liu et al.   PLoS One

Alpha-lipoic acid attenuates cardiac fibrosis in Otsuka Long-Evans Tokushima Fatty rats

(2012) Jung Eun Lee et al.   Cardiovascular Diabetology

Deficiency in AMPK attenuates ethanol-induced cardiac contractile dysfunction through inhibition of autophagosome formation

(2012) Rui Guo et al.   CARDIOVASCULAR RESEARCH

C1q/Tumor Necrosis Factor-Related Protein-3, a Newly Identified Adipokine, Is a Novel Antiapoptotic, Proangiogenic, and Cardioprotective Molecule in the Ischemic Mouse Heart

(2012) Wei Yi et al.   CIRCULATION

AMP-Activated Protein Kinase Phosphorylates Cardiac Troponin I and Alters Contractility of Murine Ventricular Myocytes

(2012) Sandra Marisa Oliveira et al.   CIRCULATION RESEARCH

AMP-Activated Protein Kinase Regulation and Biological Actions in the Heart

(2012) Vlad G. Zaha et al.   CIRCULATION RESEARCH

Dissociation of Bcl-2-Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes

(2012) C. He et al.   DIABETES

The Role of PPARα in Metformin-Induced Attenuation of Mitochondrial Dysfunction in Acute Cardiac Ischemia/Reperfusion in Rats

(2012) Giselle Barreto-Torres et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypertrophic cardiomyopathy

(2012) Barry J Maron et al.   LANCET

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metformin attenuates pressure overload-induced cardiac hypertrophy via AMPK activation

(2011) Yong-nan Fu et al.   ACTA PHARMACOLOGICA SINICA

Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury

(2011) Marta A. Paiva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

C1q/TNF-Related Proteins, A Family of Novel Adipokines, Induce Vascular Relaxation Through the Adiponectin Receptor-1/AMPK/eNOS/Nitric Oxide Signaling Pathway

(2011) Qijun Zheng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A case of familial hypertrophic cardiomyopathy emphasizes the importance of parallel screening of multiple disease genes

(2011) Thomas Scheffold et al.   Clinical Research in Cardiology

Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice

(2011) Z. Xie et al.   DIABETES

Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1

(2011) Dmitri Pchejetski et al.   EUROPEAN HEART JOURNAL

Resveratrol prevents norepinephrine induced hypertrophy in adult rat cardiomyocytes, by activating NO-AMPK pathway

(2011) Sijo J. Thandapilly et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Resistin Promotes Cardiac Hypertrophy via the AMP-activated Protein Kinase/Mammalian Target of Rapamycin (AMPK/mTOR) and c-Jun N-terminal Kinase/Insulin Receptor Substrate 1 (JNK/IRS1) Pathways

(2011) Soojeong Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A small molecule AMPK activator protects the heart against ischemia–reperfusion injury

(2011) Agnes S. Kim et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Evolution in metacommunities

(2011) C. J. Goodnight   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization

(2011) S. Amato et al.   SCIENCE

Differential AMPK phosphorylation sites associated with phenylephrine vs. antihypertrophic effects of adenosine agonists in neonatal rat ventricular myocytes

(2010) Theresa Pang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival

(2010) Xiao-ming Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Metformin attenuates ventricular hypertrophy by activating the AMP-activated protein kinase-endothelial nitric oxide synthase pathway in rats

(2010) Cheng-Xi Zhang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde

(2010) Heng Ma et al.   EUROPEAN HEART JOURNAL

Deficiency of insulin-like growth factor 1 reduces vulnerability to chronic alcohol intake-induced cardiomyocyte mechanical dysfunction: role of AMPK

(2010) Wei Ge et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Activation of cardiac hypertrophic signaling pathways in a transgenic mouse with the human PRKAG2 Thr400Asn mutation

(2009) Sanjay K. Banerjee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metformin Prevents Progression of Heart Failure in Dogs

(2009) Hideyuki Sasaki et al.   CIRCULATION

Long-Term Effects of Enzyme Replacement Therapy on Fabry Cardiomyopathy

(2009) Frank Weidemann et al.   CIRCULATION

Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1

(2009) Vernon W. Dolinsky et al.   CIRCULATION

The Natriuretic Peptide Uroguanylin Elicits Physiologic Actions Through 2 Distinct Topoisomers

(2009) Nicholas G. Moss et al.   HYPERTENSION

Evidence for the Importance of Adiponectin in the Cardioprotective Effects of Pioglitazone

(2009) Ping Li et al.   HYPERTENSION

Implications of Hypertrophic Cardiomyopathy Transmitted by Sperm Donation

(2009) Barry J. Maron   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical Outcome and Phenotypic Expression in LAMP2 Cardiomyopathy

(2009) Barry J. Maron   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Use of Genetics in the Clinical Evaluation of Cardiomyopathy

(2009) Daniel P. Judge   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

(2009) Vinodkumar B. Pillai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pioglitazone attenuates cardiac hypertrophy in rats with salt-sensitive hypertension: role of activation of AMP-activated protein kinase and inhibition of Akt

(2009) Mayuko F Kato et al.   JOURNAL OF HYPERTENSION

Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3β-dependent attenuation of mitochondrial dysfunction

(2009) Sabzali Javadov et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Diagnostic, Prognostic, and Therapeutic Implications of Genetic Testing for Hypertrophic Cardiomyopathy

(2009) J. Martijn Bos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

(2009) Lei Chen et al.   NATURE

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

AMP-Activated Protein Kinase Conducts the Ischemic Stress Response Orchestra

(2008) Lawrence H. Young   CIRCULATION

Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure

(2008) Susheel Gundewar et al.   CIRCULATION RESEARCH

Metabolic Switch and Hypertrophy of Cardiomyocytes following Treatment with Angiotensin II Are Prevented by AMP-activated Protein Kinase

(2008) Bettina Johanna Stuck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Inhibits Cardiac Hypertrophy via AMP-activated Protein Kinase and Akt

(2008) Anita Y. M. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY