Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC and can be targeted by SYK inhibition

Self-Enforcing Feedback Activation between BCL6 and Pre-B Cell Receptor Signaling Defines a Distinct Subtype of Acute Lymphoblastic Leukemia

(2015) Huimin Geng et al.   CANCER CELL

The pre-B-cell receptor checkpoint in acute lymphoblastic leukaemia

(2015) J Eswaran et al.   LEUKEMIA

Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia

(2015) Zhengshan Chen et al.   NATURE

Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

(2015) Kathryn G. Roberts et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic Potential of Spleen Tyrosine Kinase Inhibition for Treating High-Risk Precursor B Cell Acute Lymphoblastic Leukemia

(2014) T. Perova et al.   Science Translational Medicine

Interference with pre-B-cell receptor signaling offers a therapeutic option for TCF3-rearranged childhood acute lymphoblastic leukemia

(2014) A van der Veer et al.   Blood Cancer Journal

Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia

(2013) F. M. Uckun et al.   BLOOD

SYK Inhibition Modulates Distinct PI3K/AKT- Dependent Survival Pathways and Cholesterol Biosynthesis in Diffuse Large B Cell Lymphomas

(2013) Linfeng Chen et al.   CANCER CELL

BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint

(2013) Srividya Swaminathan et al.   NATURE MEDICINE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

FOXO1 is a tumor suppressor in classical Hodgkin lymphoma

(2012) L. Xie et al.   BLOOD

Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia

(2012) S. L. Maude et al.   BLOOD

Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia

(2012) Vincent T. Bicocca et al.   CANCER CELL

Genetic Alterations Activating Kinase and Cytokine Receptor Signaling in High-Risk Acute Lymphoblastic Leukemia

(2012) Kathryn G. Roberts et al.   CANCER CELL

Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration

(2012) J Hoellenriegel et al.   LEUKEMIA

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

(2012) Jinghui Zhang et al.   NATURE

A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network

(2012) Seung-Tae Lee et al.   NUCLEIC ACIDS RESEARCH

SYK inhibition and response prediction in diffuse large B-cell lymphoma

(2011) S. Cheng et al.   BLOOD

Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765

(2011) S. E. M. Herman et al.   BLOOD

The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo

(2011) S. Ponader et al.   BLOOD

AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias

(2011) Stephen M. Sykes et al.   CELL

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition

(2011) Cihangir Duy et al.   NATURE

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model

(2010) M. P. Reilly et al.   BLOOD

Targeting SYK kinase-dependent anti-apoptotic resistance pathway in B-lineage acute lymphoblastic leukaemia (ALL) cells with a potent SYK inhibitory pentapeptide mimic

(2010) Fatih M. Uckun et al.   BRITISH JOURNAL OF HAEMATOLOGY

FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis

(2010) Boyi Gan et al.   CANCER CELL

Effect of Long-term Storage in TRIzol on Microarray-Based Gene Expression Profiling

(2010) W. Ma et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

The pre-B cell receptor checkpoint

(2010) Inga-Lill Mårtensson et al.   FEBS LETTERS

N-linked glycosylation selectively regulates autonomous precursor BCR function

(2010) Rudolf Übelhart et al.   NATURE IMMUNOLOGY

The PI3K Isoforms p110  and p110  Are Essential for Pre-B Cell Receptor Signaling and B Cell Development

(2010) F. Ramadani et al.   Science Signaling

Pre–B cell receptor–mediated cell cycle arrest in Philadelphia chromosome–positive acute lymphoblastic leukemia requiresIKAROSfunction

(2009) Daniel Trageser et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Erk Kinases Link Pre-B Cell Receptor Signaling to Transcriptional Events Required for Early B Cell Expansion

(2008) Tomoharu Yasuda et al.   IMMUNITY

SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway

(2008) Sebastian Herzog et al.   NATURE IMMUNOLOGY

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY