Article
Immunology
Paris M. M. Kollis, Lisa M. M. Ebert, John Toubia, Cameron R. R. Bastow, Rebecca J. J. Ormsby, Santosh I. I. Poonnoose, Sakthi Lenin, Melinda N. N. Tea, Stuart M. M. Pitson, Guillermo A. A. Gomez, Michael P. P. Brown, Tessa Gargett
Summary: This study characterized the chemokine receptor and integrin expression profiles of endogenous glioblastoma-infiltrating T cells and identified potential homing receptor-ligand pairs that could enhance the tumour-homing properties of future T-cell immunotherapies for glioblastoma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Michael E. B. FitzPatrick, Nicholas M. Provine, Lucy C. Garner, Kate Powell, Ali Amini, Sophie L. Irwin, Helen Ferry, Tim Ambrose, Peter Friend, Georgios Vrakas, Srikanth Reddy, Elizabeth Soilleux, Paul Klenerman, Philip J. Allan
Summary: This study investigates the transcriptional, phenotypic, and functional heterogeneity of human intestinal CD4(+) and CD8(+) T-RM cells using donor-derived T-RM cells from intestinal transplant recipients. Single-cell transcriptional profiling identifies two transcriptional states of CD8(+) T-RM cells, delineated by ITGAE and ITGB2 expression. The results describe the differential expression of cytotoxicity- and residency-associated genes in these populations, highlighting the complexity of T-RM cell diversity in the human intestine.
Article
Medicine, Research & Experimental
Brinda Monian, Ang A. Tu, Bert Ruiter, Duncan M. Morgan, Patrick M. Petrossian, Neal P. Smith, Todd M. Gierahn, Julia H. Ginder, Wayne G. Shreffler, J. Christopher Love
Summary: This study used single-cell RNA-Seq to investigate the dynamic changes in T cells of 12 peanut allergy patients during OIT. The results showed that specific T cell subsets play a crucial role in OIT, and the treatment outcomes are associated with individual characteristics and the expression of specific cell subsets during the treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Cell Biology
Meng Feng, Shuping Zhou, Yong Yu, Qinghong Su, Xiaofan Li, Wei Lin
Summary: Dendritic cells (DCs) are a class of antigen-presenting cells with crucial roles in immune activation and tolerance. Understanding the migration mechanisms and regulatory factors of different DC subgroups provides new insights for disease treatment, such as infection, tumors, and vaccine preparation. Various factors, including chemokines, membrane molecules, and microenvironments, influence DC migration and immunological functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Seydou Keita, Samuel Diop, Shalva Lekiashvili, Emna Chabaane, Elisabeth Nelson, Marion Strullu, Chloe Arfeuille, Fabien Guimiot, Thomas Domet, Sophie Duchez, Bertrand Evrard, Thomas Darde, Jerome Larghero, Els Verhoeyen, Ana Cumano, Elizabeth A. Macintyre, Zeinab Kasraian, Francois Jouen, Michel Goodhardt, David Garrick, Frederic Chalmel, Kutaiba Alhaj Hussen, Bruno Canque
Summary: This study reveals the three stages of lymphopoiesis in humans, including embryonic, fetal, and post-natal multi-lymphoid progenitors (MLPs). These MLPs differ in CD7 and CD10 expression and their production of CD127-/+ early lymphoid progenitors (ELPs). The transition to postnatal life is characterized by a shift from multilineage to B lineage-biased lymphopoiesis and an increase in CD127+ ELP production, which persists until puberty. Furthermore, elderly individuals exhibit a developmental transition where B cell differentiation bypasses the CD127+ compartment and branches directly from CD10+ MLPs. Functional analyses indicate that these changes are determined at the level of hematopoietic stem cells. These findings provide insights into the identity and function of human MLPs and the establishment and maintenance of adaptive immunity.
Review
Biotechnology & Applied Microbiology
Ghalya H. Banafea, Sherin Bakhashab, Huda F. Alshaibi, Peter Natesan Pushparaj, Mahmood Rasool
Summary: Mast cells play a crucial role in inflammatory diseases of the airway tract, releasing various mediators that contribute to immune cell accumulation and tissue remodeling.
Article
Medicine, Research & Experimental
Minyoung Kwak, Gulsun Erdag, Katie M. Leick, Stefan Bekiranov, Victor H. Engelhard, Craig L. Slingluff
Summary: The study found that the number of immune cells in tumor tissue is associated with specific ICH genes, influencing the infiltration of B cells and T cells. Future research should further explore the contribution of these genes to tertiary lymphoid structures and the cross-talk between homing pathways.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Annika Pfeiffer, Jennifer D. Petersen, Guido H. Falduto, David Eric Anderson, Joshua Zimmerberg, Dean D. Metcalfe, Ana Olivera
Summary: This study isolated and characterized subpopulations of KIT-containing extracellular vesicles (EVs) released by neoplastic human mast cells (huMCs). The KIT-EVs were found to have distinct protein profiles and were involved in signaling, immune responses, and cell migration. The study also revealed that KIT-EVs are transferred via heterogeneous microvesicle- and exosome-like EVs. The selective immunocapture of KIT-EVs will facilitate the enrichment of specific huMC-derived EVs from complex human samples and provide insights into their in vivo functions and potential as biomarkers.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Immunology
Xiaochun Liu, Ronghui Zhu, Yang Luo, Shangshang Wang, Yi Zhao, Zhuoqiong Qiu, Yu Zhang, Xiao Liu, Xu Yao, Xiao Li, Wei Li
Summary: This study identified two steady-state (LC1 and LC2) and two activated LC subsets in human skin epidermis and LCs derived from CD34(+) hemopoietic stem cells. LC1 were characterized as classical LCs mainly related to innate immunity and antigen processing, while LC2 were similar to monocytes or myeloid dendritic cells, involving in immune responses and leukocyte activation. These distinct human LC subsets require different developmental regulation and orchestrate reciprocal functions.
Article
Cell Biology
Marianna Tolve, Ayse Ulusoy, Nikolaos Patikas, K. Ushna S. Islam, Gabriela O. Bodea, Ece Oeztuerk, Bianca Broske, Astrid Mentani, Antonia Wagener, Karen M. J. van Loo, Stefan Britsch, Pengtao Liu, Walid T. Khaled, Emmanouil Metzakopian, Stephan L. Baader, Donato A. Di Monte, Sandra Blaess
Summary: The transcription factor BCL11A is expressed in subsets of murine and human dopamine neurons, forming specific subcircuits within the dopamine system. These Bcl11a-expressing neurons are vulnerable to neurodegeneration, as inactivation of Bcl11a increases susceptibility and results in motor behavior deficits. BCL11A is crucial for establishing and maintaining the physiological characteristics of dopamine neuron subpopulations.
Article
Immunology
Marco De Zuani, Chiara Dal Secco, Silvia Tonon, Alessandra Arzese, Carlo E. M. Pucillo, Barbara Frossi
Summary: Mast cells are important innate immune cells that can sense and respond to different stimuli. Studies have shown that mast cells can develop immunological memory, and their responses can be shaped by different stimulatory environments.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Sudhir Kumar Chauhan, Raquel Bartolome Casado, Ole J. B. Landsverk, Hanna Johannessen, Danh Phung, Hogne Roed Nilsen, Frank Saetre, Jorgen Jahnsen, Rune Horneland, Sheraz Yaqub, Einar Martin Aandahl, Knut E. A. Lundin, Espen S. Baekkevold, Frode L. Jahnsen
Summary: This study characterizes two subsets of Treg cells in the human small intestine with different phenotypes and functional capacities. Both subsets are scarce in healthy gut but increase dramatically in active celiac disease.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Rajia Bahri, Orsolya Kiss, Ian Prise, Karen M. Garcia-Rodriguez, Haris Atmoko, Julia M. Martinez-Gomez, Mitchell P. Levesque, Reinhard Dummer, Michael P. Smith, Claudia Wellbrock, Silvia Bulfone-Paus
Summary: Cutaneous melanoma is a highly aggressive malignancy with increasing incidence. Mast cells (MCs) associated with melanoma stroma (MAMCs) play a role in melanoma development and prognosis through unique gene expression patterns and upregulation of complement component C3.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Ece Somuncular, Julia Hauenstein, Prajakta Khalkar, Anne-Sofie Johansson, Ozge Dumral, Nicolai S. Frengen, Charlotte Gustafsson, Giuseppe Mocci, Tsu-Yi Su, Hugo Brouwer, Christine L. Trautmann, Michael Vanlandewijck, Stuart H. Orkin, Robert Mansson, Sidinh Luc
Summary: This study reveals the heterogeneity of hematopoietic stem cells (HSCs) and provides insights into the functional differences and regulatory mechanisms of HSCs through transcriptional and epigenetic mechanisms.
Article
Medicine, Research & Experimental
Diego A. Espinoza, Carole Le Coz, Emylette Cruz Cabrera, Neil Romberg, Amit Bar-Or, Rui Li
Summary: Using single-cell RNA-seq, we discovered the different activation and maturation states of tonsil-derived B cells, reflecting antigen recognition and transition through the germinal center reaction. We also identified a previously uncharacterized population of B cells expressing CCL4/CCL3 chemokines, which is consistent with B cell receptor/CD40 activation. Furthermore, we introduced a computational method to identify upstream transcription factor modulation during the transcriptional maturation from germinal center to antibody-secreting cells. Our dataset provides valuable insights into diverse B cell functional profiles and serves as a useful resource for studying the B cell immune compartment.
Article
Pediatrics
Takumi Shibazaki, Noriko Motoki, Yuka Misawa, Satoshi Ohira, Yuji Inaba, Makoto Kanai, Hiroshi Kurita, Yozo Nakazawa, Teruomi Tsukahara, Tetsuo Nomiyama
Summary: The study revealed that frequent use of indoor insecticide spray during pregnancy increases the risk of neonatal hyperbilirubinemia requiring phototherapy, while spray- or lotion-type insect repellents do not pose the same risk.
PEDIATRIC RESEARCH
(2021)
Letter
Allergy
Maiko Emi-Sugie, Hirohisa Saito, Kenji Matsumoto
ALLERGOLOGY INTERNATIONAL
(2021)
Review
Allergy
Keisuke Orimo, Masato Tamari, Hirohisa Saito, Kenji Matsumoto, Susumu Nakae, Hideaki Morita
Summary: Discovery of innate lymphoid cells (ILCs) has changed the classical concept of allergy mechanism and led to a better understanding of non-IgE-mediated allergic inflammation. Studies have shown heterogeneity in each ILC subset in different organs and tissues, with varying functions and activating/suppressing factors. Understanding the roles of ILCs in various organs is crucial for researching and treating inflammatory diseases.
Editorial Material
Allergy
Atsushi Kato, Whitney W. Stevens, Bruce S. Bochner
Article
Allergy
Tadech Boonpiyathad, Pongsakokorn Tantilipikorn, Kiat Ruxrungtham, Panitan Pradubpongsa, Wat Mitthamsiri, Aurelie Piedvache, Pattarawat Thantiworasit, Sunee Sirivichayakul, Alain Jacquet, Narissara Suratannon, Pantipa Chatchatee, Naho Morisaki, Hirohisa Saito, Atik Sangasapaviriya, Kenji Matsumoto, Hideaki Morita
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ken Arae, Masashi Ikutani, Kotaro Horiguchi, Sachiko Yamaguchi, Youji Okada, Hiroki Sugiyama, Keisuke Orimo, Hideaki Morita, Hajime Suto, Ko Okumura, Haruhiko Taguchi, Kenji Matsumoto, Hirohisa Saito, Katsuko Sudo, Susumu Nakae
Summary: Our study demonstrates that chitin induces the production of IL-33 and TSLP by alveolar and bronchial epithelial cells in mice. These cytokines play a crucial role in activating resident lung Th2 cells and ILC2s, leading to the development of chitin-induced airway eosinophilia.
SCIENTIFIC REPORTS
(2021)
Review
Allergy
Atsushi Kato, Anju T. Peters, Whitney W. Stevens, Robert P. Schleimer, Bruce K. Tan, Robert C. Kern
Summary: The study of chronic rhinosinusitis (CRS) has shifted from phenotype-based classification to endotype-based classification, identifying three main endotypes that orchestrate the expression of different gene sets. The development of improved methods for endotyping disease is expanding the use of biological therapies, targeting Type 2 inflammation and potentially other inflammatory endotypes in the future.
Article
Allergy
Keisuke Orimo, Masato Tamari, Tomohiro Takeda, Terufumi Kubo, Beate Ruckert, Kenichiro Motomura, Hiroki Sugiyama, Ayako Yamada, Kyoko Saito, Ken Arae, Motohiro Kuriyama, Mariko Hara, Michael B. Soyka, Masashi Ikutani, Sota Yamaguchi, Noriko Morimoto, Kazuhiko Nakabayashi, Kenichiro Hata, Akio Matsuda, Cezmi A. Akdis, Katsuko Sudo, Hirohisa Saito, Susumu Nakae, Jun Tamaoki, Etsuko Tagaya, Kenji Matsumoto, Hideaki Morita
Summary: The study found that platelets spontaneously adhere to ILC2, enhancing the responses of ILC2 to IL-33 in the peripheral blood and airways. In vivo, T2 inflammation and T2 cytokine production were significantly reduced in mice lacking c-mpl.
Editorial Material
Allergy
Hideaki Morita, Hirohisa Saito, Kenji Matsumoto
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Letter
Allergy
Hiroki Yasudo, Tomoaki Ando, Jiro Kitaura, Nobuyuki Maruyama, Masami Narita, Osamu Natsume, Kei Uneoka, Katsushi Miura, Yoshinori Morita, Anna Kamei, Yoko Okamoto, Seigo Shirakawa, Taeru Kitabayashi, Kazuyuki Kurihara, Kazuyoshi Nogami, Yoshihiro Takasato, Mizuho Nagao, Komei Ito, Takao Fujisawa, Motohiro Ebisawa, Toshiaki Kawakami, Kenji Matsumoto, Hirohisa Saito, Shunji Hasegawa, Yukihiro Ohya
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Review
Allergy
Atsushi Kato, Robert P. Schleimer, Benjamin S. Bleier
Summary: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by inflammation in the upper airways, which can be divided into two main types based on the presence of nasal polyps. The inflammation is characterized by three different endotypes based on the elevation of specific cytokines. The sinonasal epithelium plays a crucial role in the pathogenesis of CRS by acting as a barrier and participating in both innate and adaptive immunity. Further research is needed to fully understand the mechanisms of CRS pathogenesis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Sakura Sato, Noriyuki Yanagida, Komei Ito, Yoshitaka Okamoto, Hirohisa Saito, Masami Taniguchi, Makoto Nagata, Hirokuni Hirata, Masao Yamaguchi, Ruby Pawankar, Motohiro Ebisawa
Summary: This study conducted the first nationwide epidemiological survey on anaphylaxis in Japan. The results showed that children were the main population affected by anaphylaxis, with food and drugs being the most common triggers. Intramuscular injection of adrenaline was commonly used for treatment. The findings highlight the importance of comprehensive education and training on anaphylaxis.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Allergy
Brian S. Schwartz, Jonathan S. Pollak, Karen Bandeen-Roche, Annemarie G. Hirsch, Ashton E. Lehmann, Robert C. Kern, Bruce K. K. Tan, Atsushi Kato, Robert P. Schleimer, Anju T. Peters
Summary: This study investigates the association between chronic rhinosinusitis (CRS) and new onset asthma. By analyzing electronic health record data from Geisinger, it is found that prevalent CRS is associated with the diagnosis of new onset adult asthma in the following year. These findings have clinical implications for asthma prevention.
Article
Allergy
Marcus M. Soliai, Atsushi Kato, Katherine A. Naughton, James E. Norton, Aiko I. Klinger, Robert C. Kern, Bruce K. K. Tan, Dan L. Nicolae, Robert P. Schleimer, Carole Ober, Jayant M. Pinto
Summary: This study investigated the epigenetic and transcriptional responses in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) to rhinovirus (RV) using a primary sinonasal epithelial cell culture model. They found that RV activates specific epigenetic programs and correlated transcriptional networks in the sinonasal epithelium of individuals with CRSwNP, suggesting potential therapeutic targets for this condition.
Letter
Allergy
Brian S. Schwartz, Annemarie G. Hirsch, Karen Bandeen-Roche, Atsushi Kato, Robert Schleimer