Article
Cell Biology
Mengyuan Liu, Heming Li, Huijing Zhang, Huan Zhou, Taiwei Jiao, Mingliang Feng, Fangjian Na, Mingjun Sun, Mingfang Zhao, Lei Xue, Lu Xu
Summary: By analyzing high-throughput sequencing datasets, this study identified RBMS1 as a potential promoter gene for gastric cancer metastasis, which activates the JAK2/STAT3 signaling pathway and IL-6 transcriptional activation, promoting cell migration and invasion.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Zhengzhong Wu, Leye Yan, Junqing Lin, Kun Ke, Weizhu Yang
Summary: The study demonstrated that TDO2 expression leads to liver cancer by upregulating Trp metabolism. TDO2 expression was positively correlated with poor prognosis in liver cancer patients, and it promoted liver cancer cell proliferation by releasing Kyn to activate AhR. AhR signals may serve as a valuable therapeutic target for tumor therapy.
CANCER CELL INTERNATIONAL
(2021)
Article
Immunology
Rodolfo Soria-Castro, Angel R. Alfaro-Doblado, Gloria Rodriguez-Lopez, Marcia Campillo-Navarro, Yatsiri G. Meneses-Preza, Adrian Galan-Salinas, Violeta Alvarez-Jimenez, Juan C. Yam-Puc, Rosario Munguia-Fuentes, Adriana Dominguez-Flores, Sergio Estrada-Parra, Sonia M. Perez-Tapia, Alma D. Chavez-Blanco, Rommel Chacon-Salinas
Summary: The study found that MC infected with L.m were able to clear the bacterial load and responded by degranulating and producing various cytokines. TLR2 was shown to mediate some MC activation pathways during L.m infection, particularly those related to IL-6 and IL-13 production. Interestingly, p38 activation depended on TLR2, but not ERK or NF-kappa B activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Marcela T. Taruselli, Elizabeth Motunrayo Kolawole, Amina Abdul Qayum, Tamara T. Haque, Heather L. Caslin, Daniel Abebayehu, Sydney A. Kee, Jordan M. Dailey, Kaitlyn G. Jackson, Jason R. Burchett, Andrew J. Spence, Neha Pondicherry, Brian O. Barnstein, Gregorio Gomez, David B. Straus, John J. Ryan
Summary: This study found that fluvastatin enhances mast cell response to IL-33, promoting mast cell-mediated inflammatory reactions, and reveals the underlying mechanisms. These findings emphasize the importance of understanding the pleiotropic and potential unexpected effects of statins.
CELLULAR IMMUNOLOGY
(2022)
Article
Immunology
Tiziana Annese, Roberto Tamma, Mariella Bozza, Alfredo Zito, Domenico Ribatti
Summary: c-Kit receptor is expressed and involved in various biological processes in mucosal mast cells, such as cell survival, proliferation, hematopoiesis, and melanogenesis. This study found that in melanoma, mast cells express and release SCF and c-Kit receptors, potentially regulating tumor progression through an autocrine/paracrine loop.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yanmiao Huo, Jian Yang, Jiahao Zheng, Dapeng Xu, Minwei Yang, Lingye Tao, Hongfei Yao, Xueliang Fu, Jianyu Yang, Dejun Liu, Rong Hua, Junfeng Zhang, Yongwei Sun, Lipeng Hu, Wei Liu
Summary: This study found that SPON1 is significantly upregulated in pancreatic ductal adenocarcinoma (PDAC) and promotes tumor growth and development by activating the sIL-6R/gp130/STAT3 pathway. These results suggest that SPON1 may be a potential therapy target for PDAC patients.
CELL PROLIFERATION
(2022)
Article
Biochemistry & Molecular Biology
Yuka Nagasaka, Yuki Nakamura, Nguyen Quoc Vuong Tran, Yoshiaki Kobayashi, Nobuhiro Nakano, Atsuhito Nakao
Summary: This study found that Bmal1 plays a regulatory role in the expression of anti-oxidative genes in mast cells, and deficiency of Bmal1 enhances IgE-dependent mast cell degranulation associated with promotion of ROS generation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Oncology
Silu Wang, Linyong Du, Hao Chen, Xing Zhang, Bicheng Chen, Lihong Yang
Summary: In pancreatic cancer patients, high levels of the cytokine IL-6 were found in the blood serum, while pancreatic cancer cells themselves exhibited low expression of IL-6. The study uncovered the key role of the Jagged/Notch/IL-6/STAT3 positive feedback loop in the development of a hypercoagulable state in pancreatic cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Stefania Nicola, Irene Ridolfi, Giovanni Rolla, Pierluigi Filosso, Roberto Giobbe, Monica Boita, Beatrice Culla, Caterina Bucca, Paolo Solidoro, Luisa Brussino
Summary: This study found significantly higher levels of Th1 and Th17-related cytokines in the exhaled breath condensate of patients with non-small cell lung cancer compared to healthy controls, while no significant differences were observed for Th2-related cytokines. Significant correlations were found between FeNO levels and Th17-related cytokines, suggesting that IL-17 may indirectly contribute to increased lung production of nitric oxide in patients with NSCLC.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Marianna Kulka, Ashley Wagner, Jae-Young Cho, Syed Benazir Alam, Joy Ramielle Santos, Juan Jovel, Leshern Karamchand, Marcelo Marcet-Palacios
Summary: Researchers cultured bone marrow derived mast cells in a matrix containing crystalline nanocellulose (CNC), which had no effect on cell viability but inhibited the production of certain mediators. This study may contribute to understanding the functional expression of cells in specific environments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Esther B. Florsheim, Nathaniel D. Bachtel, Jaime L. Cullen, Bruna G. C. Lima, Mahdieh Godazgar, Fernando Carvalho, Carolina P. Chatain, Marcelo R. Zimmer, Cuiling Zhang, Gregory Gautier, Pierre Launay, Andrew Wang, Marcelo O. Dietrich, Ruslan Medzhitov
Summary: In addition to protecting the body from pathogens, the immune system can also affect behavior. In this study using mouse models of food allergy, it was found that allergic sensitization leads to antigen-specific avoidance behavior. The avoidance of allergens activates certain brain areas involved in aversive stimuli response. IgE antibodies and mast cells are necessary for allergen avoidance, and cysteinyl leukotrienes and growth and differentiation factor 15 play a role in promoting avoidance. Genetic background also influences avoidance behavior. These findings suggest that antigen-specific behavioral modifications may have evolved to avoid unfavorable environments.
Article
Medicine, Research & Experimental
Xin Chen, Chennan Wang, Na Sun, Shuai Pan, Rongqing Li, Xueqin Li, Jie Zhao, Huan Tong, Yangyang Tang, Jing Han, Jianlin Qiao, Hongbin Qiu, Hui Wang, Jing Yang, Takayuki Ikezoe
Summary: This study revealed that deletion of Aurka in CD19(+) B cells results in increased production of IL-6, promoting STAT3 activation, which in turn contributes to TPO transcription and megakaryocytopoiesis.
Article
Gastroenterology & Hepatology
Xin Hou, Shi Yin, Ruixue Ren, Siqi Liu, Liang Yong, Yuxiao Liu, Yu Li, Ming-Hua Zheng, George Kunos, Bin Gao, Hua Wang
Summary: This study investigated the role of IL-6 signaling in NAFLD by regulating antifibrotic microRNA-223 in myeloid cells. The results showed that myeloid-specific IL-6 signaling inhibits liver fibrosis through exosomal transfer of antifibrotic miR-223 into hepatocytes. These findings provide potential therapeutic targets for the treatment of NAFLD.
Article
Multidisciplinary Sciences
Eva Conde, Romain Bertrand, Bianca Balbino, Jonathan Bonnefoy, Julien Stackowicz, Noemie Caillot, Fabien Colaone, Samir Hamdi, Raissa Houmadi, Alexia Loste, Jasper B. J. Kamphuis, Francois Huetz, Laurent Guilleminault, Nicolas Gaudenzio, Aurelie Mougel, David Hardy, John N. Snouwaert, Beverly H. Koller, Vincent Serra, Pierre Bruhns, Geraldine Grouard-Vogel, Laurent L. Reber
Summary: The study developed vaccines targeting IL-4 and IL-13, demonstrating promising prophylactic and therapeutic effects in mouse models of asthma. Vaccines specific for human IL-4 and IL-13 also showed efficient neutralization of these cytokines in mice, suggesting a potential long-term therapeutic strategy for allergic asthma.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Fiona N. Kenny, Stefania Marcotti, Deandra Belo De Freitas, Elena M. Drudi, Vivienne Leech, Rachel E. Bell, Jennifer Easton, Maria-del-Carmen Diaz-de-la-Loza, Roland Fleck, Leanne Allison, Christina Philippeos, Angelika Manhart, Tanya J. Shaw, Brian M. Stramer
Summary: This study investigates the organization of fibrotic extracellular matrix (ECM) by studying keloid scars. The results suggest that cell alignment and cell-cell adhesions play a crucial role in the development of fibrotic ECM. IL-6 signaling and cell-cell adhesions are identified as potential therapeutic targets for inhibiting fibrosis.
Article
Respiratory System
David Bilocca, B. Hargadon, I. D. Pavord, R. H. Green, C. E. Brightling, P. Bradding, A. J. Wardlaw, N. Martin, A. C. Murphy, S. Siddiqui
CHRONIC RESPIRATORY DISEASE
(2018)
Review
Immunology
Peter Bradding, Gunnar Pejler
IMMUNOLOGICAL REVIEWS
(2018)
Article
Critical Care Medicine
Liam G. Heaney, John Busby, Peter Bradding, Rekha Chaudhuri, Adel H. Mansur, Robert Niven, Ian D. Pavord, John T. Lindsay, Richard W. Costello
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Letter
Respiratory System
Rahul Shrimanker, Ian D. Pavord, Steve Yancey, Liam G. Heaney, Ruth H. Green, Peter Bradding, Beverley Hargadon, Chris E. Brightling, Andrew J. Wardlaw, Pranabashis Haldar
EUROPEAN RESPIRATORY JOURNAL
(2018)
Article
Engineering, Biomedical
Eunice Chee, Seema Nandi, Kimberly Nellenbach, Emily Mihalko, Douglas B. Snider, Landon Morrill, Andrew Bond, Erin Sproul, Jennifer Sollinger, Glenn Cruse, Maureane Hoffman, Ashley C. Brown
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2020)
Article
Cell Biology
Santosh K. Mishra, Joshua J. Wheeler, Saumitra Pitake, Huiping Ding, Changyu Jiang, Tomoki Fukuyama, Judy S. Paps, Patrick Ralph, Jacob Coyne, Michelle Parkington, Jennifer DeBrecht, Lauren C. Ehrhardt-Humbert, Glenn P. Cruse, Wolfgang Baeumer, Ru-Rong Ji, Mei-Chuan Ko, Thierry Olivry
Article
Cell Biology
Greer K. Arthur, Lauren C. Ehrhardt-Humbert, Douglas B. Snider, Corey Jania, Stephen L. Tilley, Dean D. Metcalfe, Glenn Cruse
CELLULAR SIGNALLING
(2020)
Article
Cell & Tissue Engineering
Emily W. Ozpinar, Ariana L. Frey, Greer K. Arthur, Camilo Mora-Navarro, Andreea Biehl, Douglas B. Snider, Glenn Cruse, Donald O. Freytes
Summary: Mast cells are pro-inflammatory tissue-resident immune cells that play a key role in inflammation and show significant variability in response to environmental stimuli due to in situ maturation in tissue. Studying mature tissue-derived MCs in humans poses challenges, but using decellularized ECM scaffolds can provide a more physiologically relevant environment for culture.
TISSUE ENGINEERING PART A
(2021)
Article
Cell & Tissue Engineering
Emily W. Ozpinar, Ariana L. Frey, Glenn Cruse, Donald O. Freytes
Summary: Tissue engineers often utilize biomaterials to aid wound healing, with a focus on modulating inflammation. Mast cells play an important role in this process by recognizing antigens and releasing granules that affect various aspects of tissue repair. Understanding mast cell interactions with biomaterials can enhance the design of optimized implants for tissue repair and regeneration.
TISSUE ENGINEERING PART B-REVIEWS
(2021)
Article
Biotechnology & Applied Microbiology
Douglas B. Snider, Greer K. Arthur, Guido H. Falduto, Ana Olivera, Lauren C. Ehrhardt-Humbert, Emmaline Smith, Cierra Smith, Dean D. Metcalfe, Glenn Cruse
Summary: This study developed an innovative approach using chemically stable exon skipping oligonucleotides (ESOs) to target KIT expression, which resulted in downregulation of KIT, inhibition of MC proliferation, and induction of apoptosis in neoplastic cells. In vivo administration of KIT targeting ESOs significantly inhibited tumor growth and organ infiltration, suggesting its potential as a therapeutic strategy for KIT-associated malignancies.
Article
Medicine, Research & Experimental
Xiaomei Kong, William C. Bennett, Corey M. Jania, Kelly D. Chason, Zachary German, Jennifer Adouli, Samuel D. Budney, Brandon T. Oby, Catharina van Heusden, Eduardo R. Lazarowski, Ilona Jaspers, Scott H. Randell, Barry A. Hedgespeth, Glenn Cruse, Xiaoyang Hua, Stephen A. Schworer, Gregory J. Smith, Samir Np Kelada, Stephen L. Tilley
Summary: This study shows that ozone induces mast cell degranulation and bronchial hyperresponsiveness, with P2X7 receptors playing a crucial role in the process.
Review
Biochemistry & Molecular Biology
Greer K. Arthur, Glenn Cruse
Summary: Mast cells are immune cells involved in allergic inflammatory response. This review focuses on IgE-mediated activation and discusses the structure and function of Fc epsilon RI, as well as the role of Fc epsilon RI beta in regulating mast cell function and signaling. Current and emerging approaches to target IgE and Fc epsilon RI signaling are discussed, along with the potential therapeutic use of alternative splicing of Fc epsilon RI beta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Katie Bitting, Barry Hedgespeth, Lauren C. Ehrhardt-Humbert, Greer K. Arthur, Alicia G. Schubert, Peter Bradding, Stephen L. Tilley, Glenn Cruse
Summary: This study found that the Fc epsilon RI beta-like protein MS4A6A exists in human mast cells and can compensate for the role of Fc epsilon RI beta in trafficking and signaling.
Article
Immunology
Barry A. A. Hedgespeth, Douglas B. Snider, Katie J. Bitting, Glenn Cruse
Summary: This article introduces a oligonucleotide called KitStop, which can safely reduce the severity and duration of anaphylactic response by reducing the number of mast cells in tissues. The study shows that KitStop significantly reduces mast cell numbers in the skin and peritoneum, and mice treated with KitStop experience a significantly diminished anaphylactic response in a model of passive systemic anaphylaxis compared to control mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Lizette M. Cortes, David Brodsky, Celine Chen, Tiffany Pridgen, Jack Odle, Douglas B. Snider, Glenn Cruse, Arina Putikova, Mia Y. Masuda, Alfred D. Doyle, Benjamin L. Wright, Harry D. Dawson, Anthony Blikslager, Evan S. Dellon, Scott M. Laster, Tobias Kaser
Summary: This study aimed to establish swine as a large animal model for EoE and demonstrated that swine can develop immunological and pathological markers similar to human EoE after sensitization and challenge treatment.
FRONTIERS IN ALLERGY
(2022)