Protective role of ACE2-Ang-(1–7)-Mas in myocardial fibrosis by downregulating KCa3.1 channel via ERK1/2 pathway

A pharmacologic activator of endothelial KCa channels increases systemic conductance and reduces arterial pressure in an anesthetized pig model

(2016) Ramesh C. Mishra et al.   VASCULAR PHARMACOLOGY

Angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis activates Akt signaling to ameliorate hepatic steatosis

(2016) Xi Cao et al.   Scientific Reports

Uterine artery dysfunction in pregnant ACE2 knockout mice is associated with placental hypoxia and reduced umbilical blood flow velocity

(2015) Liliya M. Yamaleyeva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Upregulation of Angiotensin (1-7)-Mediated Signaling Preserves Endothelial Function Through Reducing Oxidative Stress in Diabetes

(2015) Yang Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Angiotensin-Converting Enzyme 2 Inhibits Apoptosis of Pulmonary Endothelial Cells During Acute Lung Injury Through Suppressing SMAD2 Phosphorylation

(2015) Yong Ji et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Blockade of KCa3.1 Attenuates Left Ventricular Remodeling after Experimental Myocardial Infarction

(2015) Chen-Hui Ju et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

KCa3.1

(2015) Chunling Huang et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Inhibition of Myogenic Tone in Rat Cremaster and Cerebral Arteries by SKA-31, an Activator of Endothelial KCa2.3 and KCa3.1 Channels

(2015) Ramesh C. Mishra et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Perinatally administered losartan augments renal ACE2 expression but not cardiac or renal Mas receptor in spontaneously hypertensive rats

(2015) Jan Klimas et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The role of KCa3.1 channels in cardiac fibrosis induced by pressure overload in rats

(2015) Li-Mei Zhao et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Angiotensin-(1–7) and angiotensin-(1–9): function in cardiac and vascular remodelling

(2014) Clare A. McKinney et al.   CLINICAL SCIENCE

Role of angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis in the hypotensive effect of azilsartan

(2014) Jun Iwanami et al.   HYPERTENSION RESEARCH

A pharmacologic activator of endothelial KCa channels enhances coronary flow in the hearts of type 2 diabetic rats

(2014) Ramesh C. Mishra et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Perturbation of chemical coupling by an endothelial Cx40 mutant attenuates endothelium-dependent vasodilation by KCa channels and elevates blood pressure in mice

(2014) Daniel J. Chaston et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Inhibition of the K+ Channel KCa3.1 Reduces TGF-β1-Induced Premature Senescence, Myofibroblast Phenotype Transition and Proliferation of Mesangial Cells

(2014) Rong-Guo Fu et al.   PLoS One

Targeted Inhibition of KCa3.1 Channel Attenuates Airway Inflammation and Remodeling in Allergic Asthma

(2013) Zhi-Hua Yu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Angiotensin II upregulates KCa3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts

(2013) Li-Ping Wang et al.   BIOCHEMICAL PHARMACOLOGY

Activation of KCa3.1 by SKA-31 induces arteriolar dilatation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice

(2013) Josephine Radtke et al.   BRITISH JOURNAL OF PHARMACOLOGY

Blockade of KCa3.1 Ameliorates Renal Fibrosis Through the TGF-β1/Smad Pathway in Diabetic Mice

(2013) Chunling Huang et al.   DIABETES

KCa3.1 mediates activation of fibroblasts in diabetic renal interstitial fibrosis

(2013) C. Huang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

SKA-31, a novel activator of SKCa and IKCa channels, increases coronary flow in male and female rat hearts

(2012) Ramesh C. Mishra et al.   CARDIOVASCULAR RESEARCH

Enhanced Angiotensin II-Induced Cardiac and Aortic Remodeling in ACE2 Knockout Mice

(2012) Mahmoud S. Alghamri et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

KCa3.1 channels mediate the increase of cell migration and proliferation by advanced glycation endproducts in cultured rat vascular smooth muscle cells

(2012) Li-Mei Zhao et al.   LABORATORY INVESTIGATION

Exercise induces renin–angiotensin system unbalance and high collagen expression in the heart of Mas-deficient mice

(2012) Gislaine G. Guimarães et al.   PEPTIDES

Advanced glycation end products promote proliferation of cardiac fibroblasts by upregulation of KCa3.1 channels

(2012) Li-Mei Zhao et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Angiotensin-(1-7) receptor Mas is an essential modulator of extracellular matrix protein expression in the heart

(2012) Elisandra Gava et al.   REGULATORY PEPTIDES

Insulin-mediated upregulation of KCa3.1 channels promotes cell migration and proliferation in rat vascular smooth muscle

(2011) Xing-Li Su et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ACE2/ANG-(1–7)/Mas pathway in the brain: the axis of good

(2010) Ping Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Angiotensin-converting enzyme 2 is a key modulator of the renin–angiotensin system in cardiovascular and renal disease

(2010) Chris Tikellis et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Effects of intracerebroventricular infusion of angiotensin-(1–7) on bradykinin formation and the kinin receptor expression after focal cerebral ischemia–reperfusion in rats

(2008) Jie Lu et al.   BRAIN RESEARCH

Central administration of angiotensin-(1–7) stimulates nitric oxide release and upregulates the endothelial nitric oxide synthase expression following focal cerebral ischemia/reperfusion in rats

(2008) Yingdong Zhang et al.   NEUROPEPTIDES