Antiviral therapeutic approaches for human rhinovirus infections

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

(2018) Aurélie Mousnier et al.   Nature Chemistry

Comparative effectiveness of aerosolized versus oral ribavirin for the treatment of respiratory syncytial virus infections: A single-center retrospective cohort study and review of the literature

(2018) Tracy P. Trang et al.   Transplant Infectious Disease

Update in the treatment of non-influenza respiratory virus infection in solid organ transplant recipients

(2017) Shellee A. Grim et al.   EXPERT OPINION ON PHARMACOTHERAPY

Recurrent rhinovirus infections in a child with inherited MDA5 deficiency

(2017) Ian T. Lamborn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response

(2017) Nam Nam Cheung et al.   JOURNAL OF GENERAL VIROLOGY

Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration

(2017) Fern Findlay et al.   JOURNAL OF IMMUNOLOGY

A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication

(2017) Jinwoo Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication

(2017) Anabel Guedán et al.   JOURNAL OF VIROLOGY

Global epidemiology of non-influenza RNA respiratory viruses: data gaps and a growing need for surveillance

(2017) Julian W Tang et al.   LANCET INFECTIOUS DISEASES

PLA2G16 represents a switch between entry and clearance of Picornaviridae

(2017) Jacqueline Staring et al.   NATURE

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

(2017) Valeria Cagno et al.   NATURE MATERIALS

Cathelicidins display conserved direct antiviral activity towards rhinovirus

(2017) Filipa Henderson Sousa et al.   PEPTIDES

In-vitro effect of human cathelicidin antimicrobial peptide LL-37 on dengue virus type 2

(2017) K. Alagarasu et al.   PEPTIDES

Antibody-induced uncoating of human rhinovirus B14

(2017) Yangchao Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

(2017) Adrian R Martineau et al.   BMJ-British Medical Journal

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

(2017) Adrian R Martineau et al.   BMJ-British Medical Journal

Antibody therapies for the prevention and treatment of viral infections

(2017) Georgina Salazar et al.   npj Vaccines

Susceptibilities of enterovirus D68, enterovirus 71, and rhinovirus 87 strains to various antiviral compounds

(2016) Donald F. Smee et al.   ANTIVIRAL RESEARCH

Design and structure–activity relationships of novel inhibitors of human rhinovirus 3C protease

(2016) S.P. Kawatkar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Approved Antiviral Drugs over the Past 50 Years

(2016) Erik De Clercq et al.   CLINICAL MICROBIOLOGY REVIEWS

Development of intranasal nanovehicles of itraconazole and their immunological activities for the therapy of rhinovirus infection

(2016) Jeong-Jun Lee et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

A review of treatment modalities for Middle East Respiratory Syndrome

(2016) Yin Mo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The conserved N-terminus of human rhinovirus capsid protein VP4 contains membrane pore-forming activity and is a target for neutralizing antibodies

(2016) Anusha Panjwani et al.   JOURNAL OF GENERAL VIROLOGY

Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans

(2016) Silke M. Currie et al.   JOURNAL OF IMMUNOLOGY

Therapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model

(2016) Aeri Shim et al.   Scientific Reports

Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37

(2015) Aline Schögler et al.   EUROPEAN RESPIRATORY JOURNAL

Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication

(2015) Yury A. Bochkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses

(2015) Céline Lacroix et al.   Virology Journal

Modulation of the Immune Response to Respiratory Viruses by Vitamin D

(2015) Claire Greiller et al.   Nutrients

Vitamin D Status and Acute Respiratory Infection: Cross Sectional Results from the United States National Health and Nutrition Examination Survey, 2001–2006

(2015) Dominique Monlezun et al.   Nutrients

Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein

(2015) Jeroen R.P.M. Strating et al.   Cell Reports

Challenges in developing a cross-serotype rhinovirus vaccine

(2015) Nicholas Glanville et al.   Current Opinion in Virology

Nasal Levels of Antimicrobial Peptides in Allergic Asthma Patients and Healthy Controls: Differences and Effect of a Short 1,25(OH)2 Vitamin D3 Treatment

(2015) Willemien Thijs et al.   PLoS One

Rhinovirus Uses a Phosphatidylinositol 4-Phosphate/Cholesterol Counter-Current for the Formation of Replication Compartments at the ER-Golgi Interface

(2014) Pascal S. Roulin et al.   Cell Host & Microbe

Treatment of Persistent Rhinovirus Infection With Pegylated Interferon α2a and Ribavirin in Patients With Hypogammaglobulinemia

(2014) Olli Ruuskanen et al.   CLINICAL INFECTIOUS DISEASES

Respiratory Epithelial Cells Convert Inactive Vitamin D to Its Active Form: Potential Effects on Host Defense

(2014) S. Hansdottir et al.   JOURNAL OF IMMUNOLOGY

Effects of Vitamin D on Airway Epithelial Cell Morphology and Rhinovirus Replication

(2014) Rebecca A. Brockman-Schneider et al.   PLoS One

Efficacy of IFN-λ1 to Protect Human Airway Epithelial Cells against Human Rhinovirus 1B Infection

(2014) Fahad Gulraiz et al.   PLoS One

Interferon Induction by RNA Viruses and Antagonism by Viral Pathogens

(2014) Yuchen Nan et al.   Viruses-Basel

Carrageenan nasal spray in virus confirmed common cold: individual patient data analysis of two randomized controlled trials

(2014) Martin Koenighofer et al.   MULTIDISCIPLINARY RESPIRATORY MEDICINE

Effect of exogenous interferons on rhinovirus replication and airway inflammatory responses

(2013) Tess M. Becker et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Multiple Classes of Antiviral Agents ExhibitIn VitroActivity against Human Rhinovirus Type C

(2013) Chris Mello et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal PhenotypeIn Vivo

(2013) Catherine Spickler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cationic Host Defence Peptides: Potential as Antiviral Therapeutics

(2013) Emily Gwyer Findlay et al.   BIODRUGS

Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus

(2013) Anne Décor et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Human Rhinoviruses

(2013) Samantha E. Jacobs et al.   CLINICAL MICROBIOLOGY REVIEWS

Antiviral potential of cathelicidins

(2013) Peter G Barlow et al.   Future Microbiology

Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease

(2013) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

Oxysterol-Binding Protein Family I Is the Target of Minor Enviroxime-Like Compounds

(2013) M. Arita et al.   JOURNAL OF VIROLOGY

The Human Cathelicidin LL-37 Has Antiviral Activity against Respiratory Syncytial Virus

(2013) Silke M. Currie et al.   PLoS One

An Anti-Human ICAM-1 Antibody Inhibits Rhinovirus-Induced Exacerbations of Lung Inflammation

(2013) Stephanie Traub et al.   PLoS Pathogens

The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins

(2012) S. Tripathi et al.   JOURNAL OF GENERAL VIROLOGY

Interferon-β induces a long-lasting antiviral state in human respiratory epithelial cells

(2012) Giel R. Gaajetaan et al.   JOURNAL OF INFECTION

Poly I:C Enhances Susceptibility to Secondary Pulmonary Infections by Gram-Positive Bacteria

(2012) Xiaoli Tian et al.   PLoS One

An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus

(2012) Susanne C. Feil et al.   ACS Medicinal Chemistry Letters

Towards the design of combination therapy for the treatment of enterovirus infections

(2011) Hendrik Jan Thibaut et al.   ANTIVIRAL RESEARCH

Natural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus

(2011) Scott N Dean et al.   BMC MICROBIOLOGY

Rhinoviruses, allergic inflammation, and asthma

(2011) Monica L. Gavala et al.   IMMUNOLOGICAL REVIEWS

Exogenous IFN-β has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus

(2011) Julie A. Cakebread et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Toll-Like Receptor 3-Mediated Antiviral Response Is Important for Protection against Poliovirus Infection in Poliovirus Receptor Transgenic Mice

(2011) Y. Abe et al.   JOURNAL OF VIROLOGY

Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design

(2011) G. Lu et al.   JOURNAL OF VIROLOGY

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

(2011) Peter G. Barlow et al.   PLoS One

Human rhinovirus recognition in non-immune cells is mediated byToll-like receptors and MDA-5, which trigger a synergetic pro-inflammatory immune response

(2011) Kathy Triantafilou et al.   Virulence

Experimental Rhinovirus Infection as a Human Model of Chronic Obstructive Pulmonary Disease Exacerbation

(2010) Patrick Mallia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Human Cathelicidin LL-37 Preferentially Promotes Apoptosis of Infected Airway Epithelium

(2010) Peter G. Barlow et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Analysis of the complete genome sequences of human rhinovirus

(2010) Ann C. Palmenberg et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population

(2010) Lis R.V. Antonelli et al.   JOURNAL OF CLINICAL INVESTIGATION

Flagellin Stimulates Protective Lung Mucosal Immunity: Role of Cathelicidin-Related Antimicrobial Peptide

(2010) F.-s. Yu et al.   JOURNAL OF IMMUNOLOGY

Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium

(2010) Louise Slater et al.   PLoS Pathogens

Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses

(2009) Q. Wang et al.   JOURNAL OF IMMUNOLOGY

Antibodies to the Buried N Terminus of Rhinovirus VP4 Exhibit Cross-Serotypic Neutralization

(2009) U. Katpally et al.   JOURNAL OF VIROLOGY

Toll-Like Receptor 3 Signaling on Macrophages Is Required for Survival Following Coxsackievirus B4 Infection

(2009) Martin J. Richer et al.   PLoS One

A TLR3 ligand that exhibits potent inhibition of influenza virus replication and has strong adjuvant activity has the potential for dual applications in an influenza pandemic

(2009) Yuk-Fai Lau et al.   VACCINE

Activation of toll-like receptor signaling pathway for protection against influenza virus infection

(2009) J.P. Wong et al.   VACCINE

Evasion by Stealth: Inefficient Immune Activation Underlies Poor T Cell Response and Severe Disease in SARS-CoV-Infected Mice

(2009) Jincun Zhao et al.   PLoS Pathogens

TLR3: Interferon induction by double-stranded RNA including poly(I:C)☆

(2008) M MATSUMOTO et al.   ADVANCED DRUG DELIVERY REVIEWS

Rhinovirus Disrupts the Barrier Function of Polarized Airway Epithelial Cells

(2008) Umadevi Sajjan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The management of coronavirus infections with particular reference to SARS

(2008) S. S. Y. Wong et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

(2008) Nathan W Bartlett et al.   NATURE MEDICINE

Iota-Carrageenan is a potent inhibitor of rhinovirus infection

(2008) Andreas Grassauer et al.   Virology Journal