Antibody therapies for the prevention and treatment of viral infections

Anti-retroviral antibody FcγR-mediated effector functions

(2017) Stylianos Bournazos et al.   IMMUNOLOGICAL REVIEWS

Zika Virus Infection as a Cause of Congenital Brain Abnormalities and Guillain–Barré Syndrome: Systematic Review

(2017) Fabienne Krauer et al.   PLOS MEDICINE

A First-in-Human Study To Assess the Safety and Pharmacokinetics of Monoclonal Antibodies against Human Cytomegalovirus in Healthy Volunteers

(2016) Kiran Dole et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroCharacterization of Human Cytomegalovirus-Targeting Therapeutic Monoclonal Antibodies LJP538 and LJP539

(2016) Hetalkumar D. Patel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Two Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Studies To Investigate the Safety, Tolerability, and Pharmacokinetics of an Anti-Influenza A Virus Monoclonal Antibody, MHAA4549A, in Healthy Volunteers

(2016) Jeremy J. Lim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of RG7667, a Combination Monoclonal Antibody, for Prevention of Cytomegalovirus Infection in High-Risk Kidney Transplant Recipients

(2016) Julie H. Ishida et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Hemagglutinin Stem-Binding Monoclonal Antibody VIS410 Controls Influenza Virus-Induced Acute Respiratory Distress Syndrome

(2016) Tatiana Baranovich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Safety, Tolerability, and Pharmacokinetics of MEDI8897, the Respiratory Syncytial Virus Prefusion F-Targeting Monoclonal Antibody with an Extended Half-Life, in Healthy Adults

(2016) M. Pamela Griffin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The development of therapeutic antibodies against dengue virus

(2016) Guntur Fibriansah et al.   ANTIVIRAL RESEARCH

Antiviral therapeutics for the treatment of Ebola virus infection

(2016) Anthony P Cardile et al.   CURRENT OPINION IN PHARMACOLOGY

Development of broad-spectrum human monoclonal antibodies for rabies post-exposure prophylaxis

(2016) P. De Benedictis et al.   EMBO Molecular Medicine

Progress toward active or passive HIV-1 vaccination

(2016) Amelia Escolano et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Design of a Randomized Controlled Trial for Ebola Virus Disease Medical Countermeasures: PREVAIL II, the Ebola MCM Study

(2016) Lori E. Dodd et al.   JOURNAL OF INFECTIOUS DISEASES

Preclinical pharmacokinetics of MHAA4549A, a human monoclonal antibody to influenza A virus, and the prediction of its efficacious clinical dose for the treatment of patients hospitalized with influenza A

(2016) Priyanka Gupta et al.   mAbs

HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

(2016) Johannes F. Scheid et al.   NATURE

Ultra-high-throughput sequencing of the immune receptor repertoire from millions of lymphocytes

(2016) Jonathan R McDaniel et al.   Nature Protocols

Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption

(2016) Katharine J. Bar et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Randomized, Controlled Trial of ZMapp for Ebola Virus Infection

(2016)   NEW ENGLAND JOURNAL OF MEDICINE

HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1

(2016) T. Schoofs et al.   SCIENCE

Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

(2016) Z. A. Bornholdt et al.   SCIENCE

A replication-defective human cytomegalovirus vaccine for prevention of congenital infection

(2016) D. Wang et al.   Science Translational Medicine

Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus

(2016) Q. Wang et al.   Science Translational Medicine

Understanding Ebola: the 2014 epidemic

(2016) Jolie Kaner et al.   Globalization and Health

Potent neutralizing monoclonal antibodies against Ebola virus infection

(2016) Qi Zhang et al.   Scientific Reports

Novel universal influenza virus vaccine approaches

(2016) Florian Krammer   Current Opinion in Virology

Approaches to preventative and therapeutic HIV vaccines

(2016) Glenda E Gray et al.   Current Opinion in Virology

Dengue in the Context of the Integrated Management of Childhood Illness

(2016) Jacqueline Deen et al.   PLoS Neglected Tropical Diseases

Structural basis for germline antibody recognition of HIV-1 immunogens

(2016) Louise Scharf et al.   eLife

Detection of Low Frequency Multi-Drug Resistance and Novel Putative Maribavir Resistance in Immunocompromised Pediatric Patients with Cytomegalovirus

(2016) Charlotte J. Houldcroft et al.   Frontiers in Microbiology

Human Rabies: a 2016 Update

(2016) Alan C. Jackson   Current Infectious Disease Reports

The pharmacological management of severe influenza infection – ‘existing and emerging therapies’

(2016) Aisling Mc Mahon et al.   Expert Review of Clinical Pharmacology

Safety and Upper Respiratory Pharmacokinetics of the Hemagglutinin Stalk-Binding Antibody VIS410 Support Treatment and Prophylaxis Based on Population Modeling of Seasonal Influenza A Outbreaks

(2016) Andrew M. Wollacott et al.   EBioMedicine

Research and development of Zika virus vaccines

(2016) Brian E Dawes et al.   npj Vaccines

Phase 1 Randomized, Double-Blind, Placebo-Controlled Study of RG7667, an Anticytomegalovirus Combination Monoclonal Antibody Therapy, in Healthy Adults

(2015) Julie H. Ishida et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibody with an engineered Fc region as a therapeutic agent against dengue virus infection

(2015) Ririn Ramadhany et al.   ANTIVIRAL RESEARCH

Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope

(2015) Luke N. Robinson et al.   CELL

Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults

(2015) J. E. Ledgerwood et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Engineering humoral immunity as prophylaxis or therapy

(2015) Cailin E Deal et al.   CURRENT OPINION IN IMMUNOLOGY

Prolonged suppression of HBV in mice by a novel antibody that targets a unique epitope on hepatitis B surface antigen

(2015) Tian-Ying Zhang et al.   GUT

Respiratory syncytial virus, an ongoing medical dilemma: an expert commentary on respiratory syncytial virus prophylactic and therapeutic pharmaceuticals currently in clinical trials

(2015) Lindsay Broadbent et al.   Influenza and Other Respiratory Viruses

New options in the treatment of respiratory syncytial virus disease

(2015) Asuncion Mejias et al.   JOURNAL OF INFECTION

Efficient generation of monoclonal antibodies from single rhesus macaque antibody secreting cells

(2015) Weixu Meng et al.   mAbs

A human monoclonal antibody against small envelope protein of hepatitis B virus with potent neutralization effect

(2015) Wei Wang et al.   mAbs

Human antibody technology and the development of antibodies against cytomegalovirus

(2015) Mats Ohlin et al.   MOLECULAR IMMUNOLOGY

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

(2015) Marina Caskey et al.   NATURE

Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers

(2015) G. Fibriansah et al.   SCIENCE

Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy

(2015) Seleeke Flingai et al.   Scientific Reports

Estimating the Global Burden of Endemic Canine Rabies

(2015) Katie Hampson et al.   PLoS Neglected Tropical Diseases

Proteomic Identification of Monoclonal Antibodies from Serum

(2014) Daniel R. Boutz et al.   ANALYTICAL CHEMISTRY

Broadly Neutralizing Influenza Hemagglutinin Stem-Specific Antibody CR8020 Targets Residues that Are Prone to Escape due to Host Selection Pressure

(2014) Kannan Tharakaraman et al.   Cell Host & Microbe

Rational Design and Characterization of the Novel, Broad and Potent Bispecific HIV-1 Neutralizing Antibody iMabm36

(2014) Ming Sun et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Single-Cell and Deep Sequencing of IgG-Switched Macaque B Cells Reveal a Diverse Ig Repertoire following Immunization

(2014) C. Sundling et al.   JOURNAL OF IMMUNOLOGY

Efficacy and Safety of Treatment With an Anti-M2e Monoclonal Antibody in Experimental Human Influenza

(2014) Eleanor L. Ramos et al.   JOURNAL OF INFECTIOUS DISEASES

In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation

(2014) Bing Li et al.   mAbs

Rapid development of broadly influenza neutralizing antibodies through redundant mutations

(2014) Leontios Pappas et al.   NATURE

A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus

(2014) Wanwisa Dejnirattisai et al.   NATURE IMMUNOLOGY

In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire

(2014) Brandon J DeKosky et al.   NATURE MEDICINE

A Randomized Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus

(2014) Maria Grazia Revello et al.   NEW ENGLAND JOURNAL OF MEDICINE

Progress on pursuit of human cytomegalovirus vaccines for prevention of congenital infection and disease

(2014) Tong-Ming Fu et al.   VACCINE

Characteristics of Memory B Cells Elicited by a Highly Efficacious HPV Vaccine in Subjects with No Pre-existing Immunity

(2014) Erin M. Scherer et al.   PLoS Pathogens

A Novel Investigational Fc-Modified Humanized Monoclonal Antibody, Motavizumab-YTE, Has an Extended Half-Life in Healthy Adults

(2013) Gabriel J. Robbie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Resistance of human cytomegalovirus to ganciclovir/valganciclovir: A comprehensive review of putative resistance pathways

(2013) Takashi E. Komatsu et al.   ANTIVIRAL RESEARCH

An In Vivo Human-Plasmablast Enrichment Technique Allows Rapid Identification of Therapeutic Influenza A Antibodies

(2013) Gerald Nakamura et al.   Cell Host & Microbe

High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire

(2013) Brandon J DeKosky et al.   NATURE BIOTECHNOLOGY

Isolation of human monoclonal antibodies from peripheral blood B cells

(2013) Jinghe Huang et al.   Nature Protocols

Rapid Generation of Human-Like Neutralizing Monoclonal Antibodies in Urgent Preparedness for Influenza Pandemics and Virulent Infectious Diseases

(2013) Weixu Meng et al.   PLoS One

Bispecific antibodies directed to CD4 domain 2 and HIV envelope exhibit exceptional breadth and picomolar potency against HIV-1

(2013) C. S. Pace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine

(2013) D. C. Freed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular deconvolution of the monoclonal antibodies that comprise the polyclonal serum response

(2013) Y. Wine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains

(2013) J. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibodies in HIV-1 Vaccine Development and Therapy

(2013) F. Klein et al.   SCIENCE

Monoclonal antibodies for prophylactic and therapeutic use against viral infections

(2013) Leonard Both et al.   VACCINE

HIV-1 entry inhibitors: recent development and clinical use

(2013) Timothy J Henrich et al.   Current Opinion in Virology

Therapeutic Efficacy of Antibodies Lacking FcγR against Lethal Dengue Virus Infection Is Due to Neutralizing Potency and Blocking of Enhancing Antibodies

(2013) Katherine L. Williams et al.   PLoS Pathogens

Isolation of antibody V(D)J sequences from single cell sorted rhesus macaque B cells

(2012) Christopher Sundling et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Rapid and Massive Virus-Specific Plasmablast Responses during Acute Dengue Virus Infection in Humans

(2012) J. Wrammert et al.   JOURNAL OF VIROLOGY

Dynamics of Memory B-Cell Populations in Blood, Lymph Nodes, and Bone Marrow during Antiretroviral Therapy and Envelope Boosting in Simian Immunodeficiency Virus SIVmac251-Infected Rhesus Macaques

(2012) T. Demberg et al.   JOURNAL OF VIROLOGY

Proteomics-directed cloning of circulating antiviral human monoclonal antibodies

(2012) Shuji Sato et al.   NATURE BIOTECHNOLOGY

G glycoprotein amino acid residues required for human monoclonal antibody RAB1 neutralization are conserved in rabies virus street isolates

(2011) Yang Wang et al.   ANTIVIRAL RESEARCH

Human Cytomegalovirus Escapes a Naturally Occurring Neutralizing Antibody by Incorporating It into Assembling Virions

(2011) Kate Manley et al.   Cell Host & Microbe

Critical issues in dengue vaccine development

(2011) Stephen J. Thomas et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection

(2011) Jens Wrammert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

(2011) X. Wu et al.   SCIENCE

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

(2011) J. F. Scheid et al.   SCIENCE

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

(2011) D. Corti et al.   SCIENCE

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

(2011) D. C. Ekiert et al.   SCIENCE

Phase 2a Study of the CCR5 Monoclonal Antibody PRO 140 Administered Intravenously to HIV-Infected Adults

(2010) J. M. Jacobson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity

(2010) Martina Beltramello et al.   Cell Host & Microbe

Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells

(2010) Sai T Reddy et al.   NATURE BIOTECHNOLOGY

Structural basis of respiratory syncytial virus neutralization by motavizumab

(2010) Jason S McLellan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses

(2010) Andres G. Grandea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

(2010) T. Zhou et al.   SCIENCE

The Development of Therapeutic Antibodies That Neutralize Homologous and Heterologous Genotypes of Dengue Virus Type 1

(2010) Bimmi Shrestha et al.   PLoS Pathogens

Isolation of Human Monoclonal Antibodies That Potently Neutralize Human Cytomegalovirus Infection by Targeting Different Epitopes on the gH/gL/UL128-131A Complex

(2009) A. Macagno et al.   JOURNAL OF VIROLOGY

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

(2009) Johannes F. Scheid et al.   NATURE

A rapid and efficient single-cell manipulation method for screening antigen-specific antibody–secreting cells from human peripheral blood

(2009) Aishun Jin et al.   NATURE MEDICINE

Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen

(2009) Kenneth Smith et al.   Nature Protocols

Motavizumab for Prophylaxis of Respiratory Syncytial Virus in High-Risk Children: A Noninferiority Trial

(2009) X. Carbonell-Estrany et al.   PEDIATRICS

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

(2008) Jens Wrammert et al.   NATURE

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

(2008) Mark Throsby et al.   PLoS One

First administration to humans of a monoclonal antibody cocktail against rabies virus: Safety, tolerability, and neutralizing activity

(2008) A.B.H. Bakker et al.   VACCINE