Article
Pharmacology & Pharmacy
Sravanthi Reddy Pailla, Sunitha Sampathi, Vijayabhaskarreddy Junnuthula, Sravya Maddukuri, Sujatha Dodoala, Sathish Dyawanapelly
Summary: The aim of this study was to enhance the solubility, bioavailability, and efficacy of zotepine through brain-targeted intranasal delivery of microemulsion. The optimized microemulsion formulation showed promising physicochemical properties and significantly increased drug distribution in the brain when administered through the intranasal route.
Article
Pharmacology & Pharmacy
Sara Meirinho, Marcio Rodrigues, Adriana O. Santos, Amilcar Falcao, Gilberto Alves
Summary: Stiripentol is a new-generation antiepileptic drug that can only be administered orally. However, it is unstable in acidic environments and dissolves slowly and incompletely in the gastrointestinal tract. This study developed intranasal microemulsions to improve the delivery of Stiripentol. Compared to oral administration, intranasal administration significantly increased the plasma and brain concentrations of Stiripentol, suggesting that it could be a promising alternative for clinical testing.
Article
Pharmacology & Pharmacy
Ming Ming Wen, Noha Ismail Khamis Ismail, Maha M. A. Nasra, Amal Hassan El-Kamel
Summary: The study demonstrated the use of ibuprofen microemulsion for Alzheimer's disease treatment with promising results in rat models, highlighting its novel drug delivery strategy.
Article
Multidisciplinary Sciences
Alaa Khattab, Abdulhakim Nattouf
Summary: This study aims to control the delivery of Tazarotene (TZR) through a microsponge-based gel to reduce adverse effects. By adopting the emulsion solvent diffusion methodology, different formulations of TZR microsponges were developed by varying the concentrations of polymer and emulsifier. The T1 and T3 microsponge formulations showed superior production yield and entrapment efficiency, suitable for dermal application. The optimal formulation, T8 microsponge formulation gel, released 87.63% of TZR over 12 hours.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Cristina Scomoroscenco, Mircea Teodorescu, Cristina Lavinia Nistor, Ioana Catalina Gifu, Cristian Petcu, Daniel Dumitru Banciu, Adela Banciu, Ludmila Otilia Cinteza
Summary: This study aimed to develop new microemulsion systems for topical use and identify a suitable water-soluble polymer for gel microemulsions. The efficacy of the developed microemulsion and gel microemulsion systems in delivering curcumin into the skin was also studied. A pseudo-ternary phase diagram was developed using specific ingredients, and physicochemical characterization and in vitro permeation studies were conducted.
Article
Pharmacology & Pharmacy
Asya Petkova, Ilona Kubajewska, Alexandra Vaideanu, Andreas G. Schatzlein, Ijeoma F. Uchegbu
Summary: Gene delivery to the cerebral cortex can be achieved via intranasal administration of hyaluronidase-coated polyplexes (GCPH).
Review
Chemistry, Physical
Yue Jiang, Xueting Pan, Tao Yu, Hai Wang
Summary: The existence of the blood-brain barrier (BBB) poses challenges for drug delivery to the central nervous system (CNS). Intranasal administration has emerged as an alternative method for delivering drugs to the brain by bypassing the BBB. This review focuses on the mechanisms, properties, and strategies of intranasal nanosystems for brain-targeted drug delivery. Despite promising results in animal models and clinical applications, significant challenges need to be overcome for the translation of these nanosystems into clinics. The future prospects of intranasal drug delivery nanosystems are discussed, aiming to provide insights and guidance for effective neurological disease treatment.
Article
Pharmacology & Pharmacy
Mai Mansour, Maha Nasr, Omar A. H. Ahmed-Farid, Rania F. Ahmed
Summary: This study demonstrated that ondansetron microemulsion, administered via the nasal or oral route, can alleviate the adverse effects of cisplatin chemotherapy. The nasal administration of ondansetron microemulsion showed superior effects compared to oral administration.
PHARMACOLOGICAL REPORTS
(2023)
Review
Engineering, Biomedical
Shuai Zha, Ka-Leung Wong, Angelo H. All
Summary: Intranasal delivery of nanoparticles offers a non-invasive and effective method for delivering therapeutic agents to the brain, bypassing the blood-brain barrier.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Cristina Scomoroscenco, Mircea Teodorescu, Adina Raducan, Miruna Stan, Sorina Nicoleta Voicu, Bodgan Trica, Claudia Mihaela Ninciuleanu, Cristina Lavinia Nistor, Catalin Ionut Mihaescu, Cristian Petcu, Ludmila Otilia Cinteza
Summary: This study aimed to develop and characterize new gel microemulsions for topical cosmetic applications, using grape seed oil and three different water-soluble polymers. Physico-chemical characterization and cytotoxicity evaluation showed that the gel microemulsions could effectively incorporate and control the release of hydrophobic active ingredients.
Article
Pharmacology & Pharmacy
Patrycja Szumala, Adam Macierzanka
Summary: This review focuses on recent advancements in topical microemulsion systems related to the transport of active ingredients into the skin, including those with high molecular weight and high polarity. Permeation of therapeutic macromolecules can be increased by the correct design of the microemulsion.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Sukannika Tubtimsri, Yotsanan Weerapol
Summary: A self-microemulsifying gel with improved solubility and absorption of Itraconazole (ICZ) was prepared for oral mucosa. The gel formulation with a ratio of 15:50:35 showed good elasticity and release rate. It can be used as a novel carrier for the treatment of oral candidiasis.
Article
Medicine, General & Internal
Dezhuang Ye, Jinyun Yuan, Yaoheng Yang, Yimei Yue, Zhongtao Hu, Siaka Fadera, Hong Chen
Summary: This study investigates the potential of focused ultrasound-mediated intranasal delivery (FUSIN) in delivering adeno-associated viral (AAV) vectors to the brain. The results show that FUSIN achieves safe and efficient delivery to spatially targeted brain locations and is comparable to established delivery methods.
Article
Biochemistry & Molecular Biology
Muhammad Rehan Malik, Fatemah Farraj Al-Harbi, Asif Nawaz, Adnan Amin, Arshad Farid, Mohammed Al Mohaini, Abdulkhaliq J. Alsalman, Maitham A. Al Hawaj, Yousef N. Alhashem
Summary: In this study, chitosan-decorated multiple nanoemulsion (MNE) was formulated and evaluated for its drug release and permeation properties. The MNE showed controlled release of itraconazole with significant permeation and skin drug retention, making it a promising delivery system for treating various cutaneous fungal infections.
Article
Instruments & Instrumentation
Lea-Adriana Keller, Olivia Merkel, Andreas Popp
Summary: In the last decade, there has been a growing interest in intranasal drug delivery in pharmaceutical R&D. This review article highlights the advantages of nasal delivery for local and systemic drug delivery, as well as for CNS indications, compared to conventional systemic approaches. However, formulation limitations and toxicological considerations remain areas that need further optimization in this field.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Chao-Feng Mu, Fude Cui, Yong-Mei Yin, Hyun-Jong Cho, Dae-Duk Kim
Article
Immunology
Jeonghyun Lee, Hyosung Park, Jiwon Lim, Hyung-Seung Jin, Yoon Park, Yu-Jin Jung, Hyun-Jeong Ko, Sung-Il Yoon, Geun-Shik Lee, Pyeung-Hyeun Kim, Sun Shim Choi, Changchun Xiao, Seung Goo Kang
Summary: This study reveals the crucial role of GSK3 in determining the fate of GC B cells towards plasma cell formation, by inducing changes in transcription factors required for plasma cell differentiation. This finding highlights the upstream master regulator responsible for interpreting external cues and mediating the formation of plasma cells in GC B cells.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Young-In Kim, Eun-Je Yi, Young-Dae Kim, A. Reum Lee, Jiwoung Chung, Hae Chan Ha, Joong Myung Cho, Seong-Ryeol Kim, Hyun-Jeong Ko, Jae-Hee Cheon, Yong Rae Hong, Sun-Young Chang
Summary: The novel drug CG-598 showed significant anti-inflammatory effects in an experimental murine colitis model, enhancing barrier function, reducing inflammatory lesions, and decreasing the expression of pro-inflammatory cytokines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jae-Hee Ahn, Byung-Hyun Lee, Seong-Eun Kim, Bo-Eun Kwon, Hyunjin Jeong, Jong Rip Choi, Min Jung Kim, Yong Park, Byung Soo Kim, Dae Hee Kim, Hyun-Jeong Ko
Summary: Multiple myeloma is a malignant cancer of plasma cells that remains incurable despite recent advancements in treatment. This study suggests that targeting the PD-L1 molecule with an anti-PD-L1 antibody could be a promising strategy for treating multiple myeloma, as it induces antibody-dependent cellular cytotoxicity against myeloma cells.
BIOMOLECULES & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Min-Hwan Kim, Ju-Hwan Park, Duy-Thuc Nguyen, Sungyun Kim, Da In Jeong, Hyun-Jong Cho, Dae-Duk Kim
Summary: An HAase inhibitor-incorporated hyaluronic acid hydrogel was designed to reduce toxicity risk and slow biodegradation rate in subcutaneous tissue. The hydrogel, formulated with Quercetin as an HAase inhibitor and quetiapine as a model drug, exhibited sustained drug release and improved pharmacokinetic parameters in rats following subcutaneous injection. All results supported the designed hydrogel as a biocompatible formulation for sustained drug delivery.
Article
Virology
Seong-Ryeol Kim, Myeong-Seon Jeong, Seo-Hyeon Mun, Jaewon Cho, Min-Duk Seo, Hyoungsu Kim, Jooeun Lee, Jae-Hyoung Song, Hyun-Jeong Ko
Summary: Chrysin demonstrates potent antiviral activity against A/PR/8 influenza virus by inhibiting viral infection at the early stages of the replication cycle, mainly through activation of mTOR and suppression of autophagy.
Article
Pharmacology & Pharmacy
Nae-Won Kang, So-Yeon Yoon, Sungho Kim, Na-Young Yu, Ju-Hwan Park, Jae-Young Lee, Hyun-Jong Cho, Dae-Duk Kim
Summary: The study developed a hybrid hydrogel containing microstructured lipid carriers and human serum albumin for sustained release of donepezil, which prolonged drug release and reduced initial plasma concentration in rats. The hydrogel exhibited good biocompatibility and therapeutic efficacy.
Article
Biochemistry & Molecular Biology
Jaewon Cho, Nara Tae, Jae-Hee Ahn, Sun-Young Chang, Hyun-Jeong Ko, Dae Hee Kim
Summary: Chimeric antigen receptor T (CAR-T) cell therapy has shown promising results in treating blood cancer with high overall response rate. However, it has limitations in treating solid tumors and exhibits side effects. Bispecific antibodies have the potential to engage immune cells to target cancer cells and show effective tumor killing activity in vitro and in vivo. Engaging activated T cells with cancer cells using bispecific antibodies could be a novel next generation therapy that inhibits PD-L1 and increases infiltration of activated T cells in tumor site.
BIOMOLECULES & THERAPEUTICS
(2022)
Article
Chemistry, Applied
Minyeong Kim, Seong-Ryeol Kim, Jiye Park, Seo-Hyeon Mun, Myounghai Kwak, Hyun-Jeong Ko, Seung-Hoon Baek
Summary: This study aimed to investigate the structure and anti-enterovirus 71 (EV71) effects of polysaccharides extracted from the roots of Sanguisorba officinalis (SO), traditionally used for infectious diseases. The results showed that the purified polysaccharide (S-a3) significantly inhibited cell death and viral gene expression in EV71-infected cells, and alleviated EV71-induced symptoms in a mouse model. The effective dose of S-a3 was non-toxic. This study demonstrates that polysaccharides from SO can be a safe and effective treatment for EV71 infection.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Dong-Gyun Hong, Ga Yeon Song, Cheol Bin Eom, Jae-Hee Ahn, Sun Myoung Kim, Aeri Shim, Yong-Hyun Han, Yoon-Seok Roh, Chang Yeob Han, Eun Ju Bae, Hyun-Jeong Ko, Yoon Mee Yang
Summary: This study reveals the increased expression of ERdj5 in alcoholic liver disease patients and mice. Mice lacking Dnajc10 are more susceptible to alcohol-induced liver injury and hepatic steatosis. Additionally, Dnajc10 depletion worsens oxidative stress and decreases Nrf2 pathway and glutathione contents, providing protection against liver damage.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Young-Saeng Jang, Seok-Won Yang, Tae-Gyu Kim, Ha-Eon Song, Sunhee Park, Eun Hye Lee, Seung-Goo Kang, Sung-il Yoon, Hyun-Jeong Ko, Geun-Shik Lee, Seok-Rae Park, Su Ryeon Seo, Pyeung-Hyeun Kim
Summary: The lactoferrin chimera (LFch) enhances TGF beta 1-induced Foxp3(+) Treg differentiation by diminishing TCR/CD28 signal intensity.
Article
Immunology
Eun-Je Yi, Young -In Kim, Jae-Hyoung Song, Hyun-Jeong Ko, Sun -Young Chang
Summary: Mucosal surfaces play a vital role in protecting the body from infection, and mucosal vaccine delivery is crucial for establishing pathogen-specific mucosal immunity. This study investigates the intranasal administration of curdlan and antigen to induce mucosal immune responses and protect against viral infections. The results show that co-administration of curdlan and antigen increases specific antibodies and induces the differentiation of antigen-specific cells. Furthermore, the combination of curdlan and VP1 provides effective protection against enterovirus infection and reduces tissue damage by promoting Th17 responses.
Article
Biochemistry & Molecular Biology
Hyunjin Jeong, Eun-Hye Hong, Jae-Hee Ahn, Jaewon Cho, Jae-Hyeon Jeong, Chae-Won Kim, Byung-Il Yoon, Ja Hyun Koo, Yun-Yong Park, Yoon Mee Yang, Takao Iwawaki, Bruce A. Vallance, Sun-Young Chang, Hyun-Jeong Ko
Summary: A study on inflammatory bowel disease reveals that an enzyme can protect intestinal goblet cells from cell death during gut inflammation. Modifying the molecular mechanisms of this enzyme could potentially prevent and treat inflammatory bowel disease.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Immunology
Suhyun Kim, Eun-Hye Hong, Cheol-Ki Lee, Yiseul Ryu, Hyunjin Jeong, Seungnyeong Heo, Joong-Jae Lee, Hyun-Jeong Ko
Summary: IL-22, a pleiotropic cytokine, shows potential in attenuating and treating colitis. The effective production and purification of recombinant mIL-22 in bacteria demonstrate its ability to ameliorate acute colitis and suppress pro-inflammatory cytokine production.
Article
Immunology
Seong-Ryeol Kim, Jae-Hyoung Song, Jae-Hee Ahn, Myeong Seon Jeong, Yoon Mee Yang, Jaewon Cho, Jae-Hyeon Jeong, Younggil Cha, Kil-Nam Kim, Hong Pyo Kim, Sun-Young Chang, Hyun-Jeong Ko
Summary: This study investigated the association between lipid metabolism and exacerbation of CVB3 pathology using a high-fat diet-induced obese mouse model. The results showed that lipotoxicity-induced inflammation in adipose tissue of obese mice led to increased replication of CVB3 and mortality. Additionally, inhibition of lipid-induced mtROS decreased viral replication. HFD-fed mice were more susceptible to CVB3-induced mortality, but this was ameliorated by administration of the mtROS inhibitor, MitoQ. These findings suggest that mtROS inhibitors could be potential treatments for CVB3 infection.
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
