Interferon Induction by RNA Viruses and Antagonism by Viral Pathogens

Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses

(2014) A. Forsbach et al.   JOURNAL OF IMMUNOLOGY

Hepatitis E Virus Inhibits Type I Interferon Induction by ORF1 Products

(2014) Y. Nan et al.   JOURNAL OF VIROLOGY

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

(2014) Delphine Goubau et al.   NATURE

Peroxisomal MAVS activates IRF1-mediated IFN-λ production

(2014) Siyuan Ding et al.   NATURE IMMUNOLOGY

Dengue Virus Subverts the Interferon Induction Pathway via NS2B/3 Protease-IκB Kinase ε Interaction

(2013) Yesseinia I. Angleró-Rodríguez et al.   Clinical and Vaccine Immunology

Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins

(2013) Xing Liu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Master sensors of pathogenic RNA – RIG-I like receptors

(2013) Martin Schlee   IMMUNOBIOLOGY

RNA recognition by human TLR8 can lead to autoimmune inflammation

(2013) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

(2013) Ludmila Prokunina-Olsson et al.   NATURE GENETICS

TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response

(2013) Z. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells

(2013) Puck B. van Kasteren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1

(2013) Daqi Tu et al.   Cell Reports

Cutting-Edge Report: TLR10 Plays a Role in Mediating Bacterial Peptidoglycan-Induced Trophoblast Apoptosis

(2012) Melissa J. Mulla et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming

(2012) Jieun Lee et al.   CELL

The origin and properties of extracellular DNA: From PAMP to DAMP

(2012) David S. Pisetsky   CLINICAL IMMUNOLOGY

The RIG-I-like Receptor LGP2 Controls CD8+ T Cell Survival and Fitness

(2012) Mehul S. Suthar et al.   IMMUNITY

Respiratory Syncytial Virus NS1 Protein Colocalizes with Mitochondrial Antiviral Signaling Protein MAVS following Infection

(2012) Sandhya Boyapalle et al.   PLoS One

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

Toll-like receptors in bony fish: From genomics to function

(2011) Yniv Palti   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

The Leader Proteinase of Foot-and-Mouth Disease Virus Negatively Regulates the Type I Interferon Pathway by Acting as a Viral Deubiquitinase

(2011) D. Wang et al.   JOURNAL OF VIROLOGY

Activation of IFN-β expression by a viral mRNA through RNase L and MDA5

(2011) Priya Luthra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of TLR3 Signaling Due to Cleavage of TRIF by the Hepatitis A Virus Protease-Polymerase Processing Intermediate, 3CD

(2011) Lin Qu et al.   PLoS Pathogens

The Coxsackievirus B 3Cpro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling

(2011) Amitava Mukherjee et al.   PLoS Pathogens

The Viral Interferon Regulatory Factors of KSHV: Immunosuppressors or Oncogenes?

(2011) Sarah R. Jacobs et al.   Frontiers in Immunology

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

Virus-triggered Ubiquitination of TRAF3/6 by cIAP1/2 Is Essential for Induction of Interferon-β (IFN-β) and Cellular Antiviral Response

(2010) Ai-Ping Mao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cysteine protease domain of porcine reproductive and respiratory syndrome virus non-structural protein 2 antagonizes interferon regulatory factor 3 activation

(2010) H. Li et al.   JOURNAL OF GENERAL VIROLOGY

Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKK  and DDX3

(2010) S. Yu et al.   JOURNAL OF GENERAL VIROLOGY

The Cysteine Protease Domain of Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 2 Possesses Deubiquitinating and Interferon Antagonism Functions

(2010) Z. Sun et al.   JOURNAL OF VIROLOGY

Varicella-Zoster Virus Immediate-Early Protein 62 Blocks Interferon Regulatory Factor 3 (IRF3) Phosphorylation at Key Serine Residues: a Novel Mechanism of IRF3 Inhibition among Herpesviruses

(2010) N. Sen et al.   JOURNAL OF VIROLOGY

The Chase for the RIG-I Ligand—Recent Advances

(2010) Martin Schlee et al.   MOLECULAR THERAPY

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

(2010) Marc Schmidt et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

(2010) T. Satoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of type I interferon by RNA viruses: cellular receptors and their substrates

(2009) Alina Baum et al.   AMINO ACIDS

Toll-like Receptor and RIG-1-like Receptor Signaling

(2009) Taro Kawai et al.   Annals of the New York Academy of Sciences

Interferons and viral infections

(2009) Volker Fensterl et al.   BIOFACTORS

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis*

(2009) Mark Tidswell et al.   CRITICAL CARE MEDICINE

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

(2009) Martin Schlee et al.   IMMUNITY

The Kaposi's Sarcoma-associated Herpesvirus-encoded vIRF-3 Inhibits Cellular IRF-5

(2009) Effi Wies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Caspase-mediated Decay of Interferon Regulatory Factor-3, Exploited by a Kaposi Sarcoma-associated Herpesvirus Immunoregulatory Protein

(2009) Cristina Aresté et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RIG-I-like Receptor LGP2 Recognizes the Termini of Double-stranded RNA

(2009) Xiaojun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Viral Interferon Regulatory Factors

(2009) Hye-Ra Lee et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 1  Modulates Host Innate Immune Response by Antagonizing IRF3 Activation

(2009) L. K. Beura et al.   JOURNAL OF VIROLOGY

Ebola Virus Protein VP35 Impairs the Function of Interferon Regulatory Factor-Activating Kinases IKK  and TBK-1

(2009) K. C. Prins et al.   JOURNAL OF VIROLOGY

Receptor Density Is Key to the Alpha2/Beta Interferon Differential Activities

(2009) I. Moraga et al.   MOLECULAR AND CELLULAR BIOLOGY

Key Role of Ubc5 and Lysine-63 Polyubiquitination in Viral Activation of IRF3

(2009) Wenwen Zeng et al.   MOLECULAR CELL

Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: Key regulators of innate immunity

(2009) Paola M. Barral et al.   PHARMACOLOGY & THERAPEUTICS

The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection

(2009) Laura Papon et al.   VIROLOGY

The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response

(2008) Didier Soulat et al.   EMBO JOURNAL

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKɛ-mediated IRF activation

(2008) Martina Schröder et al.   EMBO JOURNAL

Virus Infection Triggers SUMOylation of IRF3 and IRF7, Leading to the Negative Regulation of Type I Interferon Gene Expression

(2008) Toru Kubota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of TANK-binding Kinase 1-mediated Signaling by the γ134.5 Protein of Herpes Simplex Virus 1

(2008) Dustin Verpooten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Stability of the Ternary Interferon-Receptor Complex Rather than the Affinity to the Individual Subunits Dictates Differential Biological Activities

(2008) Eyal Kalie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses

(2008) Kiyohiro Takahasi et al.   MOLECULAR CELL

RIG-I plays a critical role in negatively regulating granulocytic proliferation

(2008) N.-N. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA