Cationic Host Defence Peptides: Potential as Antiviral Therapeutics

Neisseria gonorrhoeae -Induced Human Defensins 5 and 6 Increase HIV Infectivity: Role in Enhanced Transmission

(2014) Mary E. Klotman et al.   JOURNAL OF IMMUNOLOGY

Respiratory Epithelial Cells Convert Inactive Vitamin D to Its Active Form: Potential Effects on Host Defense

(2014) S. Hansdottir et al.   JOURNAL OF IMMUNOLOGY

Retrocyclin RC-101 Blocks HIV-1 Transmission Across Cervical Mucosa in an Organ Culture

(2012) Phalguni Gupta et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Serum cathelicidin level is associated with viral etiology and severity of bronchiolitis

(2012) Jonathan M. Mansbach et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

θ-Defensins: Cyclic Peptides with Endless Potential: FIGURE 1.

(2012) Robert I. Lehrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Determinants of Human α-Defensin 5 Activity against Non-enveloped Viruses

(2012) Anshu P. Gounder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multifaceted Mechanisms of HIV-1 Entry Inhibition by Human α-Defensin

(2012) Lusine H. Demirkhanyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins

(2012) S. Tripathi et al.   JOURNAL OF GENERAL VIROLOGY

Hapivirins and Diprovirins: Novel  -Defensin Analogs with Potent Activity against Influenza A Virus

(2012) M. Doss et al.   JOURNAL OF IMMUNOLOGY

Cathelicidin-Related Antimicrobial Peptide Is Required for Effective Lung Mucosal Immunity in Gram-Negative Bacterial Pneumonia

(2012) M. A. Kovach et al.   JOURNAL OF IMMUNOLOGY

 -defensin Genomic Copy Number Is Associated With HIV Load and Immune Reconstitution in Sub-Saharan Africans

(2012) R. J. Hardwick et al.   JOURNAL OF INFECTIOUS DISEASES

ß-Defensins: Multifunctional Modulators of Infection, Inflammation and More?

(2012) Fiona Semple et al.   Journal of Innate Immunity

Induction of the human cathelicidin LL-37 as a novel treatment against bacterial infections

(2012) Anne M. van der Does et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Oral human β-defensin 2 in HIV-infected subjects with long-term use of antiretroviral therapy

(2012) Wipawee Nittayananta et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000

(2012) Li Liu et al.   LANCET

AVPpred: collection and prediction of highly effective antiviral peptides

(2012) Nishant Thakur et al.   NUCLEIC ACIDS RESEARCH

HIV-Neutralizing Activity of Cationic Polypeptides in Cervicovaginal Secretions of Women in HIV-Serodiscordant Relationships

(2012) Pauline Levinson et al.   PLoS One

Human  -Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets

(2012) H. Chu et al.   SCIENCE

α-Defensins in human innate immunity

(2011) Robert I. Lehrer et al.   IMMUNOLOGICAL REVIEWS

Antimicrobial Peptides Inhibit Polyinosinic-Polycytidylic Acid-Induced Immune Responses

(2011) M. Hasan et al.   JOURNAL OF IMMUNOLOGY

Modulation of human β-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity

(2011) Lisa K. Ryan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

(2011) Bjoern O. Schroeder et al.   NATURE

Effects of cathelicidin and its fragments on three key enzymes of HIV-1

(2011) Jack Ho Wong et al.   PEPTIDES

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

(2011) Peter G. Barlow et al.   PLoS One

LL37 and Cationic Peptides Enhance TLR3 Signaling by Viral Double-stranded RNAs

(2011) Yvonne Lai et al.   PLoS One

Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment

(2011) Aprille Rapista et al.   Retrovirology

The Human Cathelicidin LL-37 Preferentially Promotes Apoptosis of Infected Airway Epithelium

(2010) Peter G. Barlow et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Recombinant mouse beta-defensin 2 inhibits infection by influenza A virus by blocking its entry

(2010) Tianxiang Gong et al.   ARCHIVES OF VIROLOGY

Strain-Specific Polymorphisms in Paneth Cell α-Defensins of C57BL/6 Mice and Evidence of Vestigial Myeloid α-Defensin Pseudogenes

(2010) Michael T. Shanahan et al.   INFECTION AND IMMUNITY

Direct Evidence from Single-Cell Analysis that Human  -Defensins Block Adenovirus Uncoating To Neutralize Infection

(2010) E. K. Nguyen et al.   JOURNAL OF VIROLOGY

A carpet-based mechanism for direct antimicrobial peptide activity against vaccinia virus membranes

(2010) R.E. Dean et al.   PEPTIDES

The Formulated Microbicide RC-101 Was Safe and Antivirally Active Following Intravaginal Application in Pigtailed Macaques

(2010) Alexander M. Cole et al.   PLoS One

Insight into the Mechanisms of Adenovirus Capsid Disassembly from Studies of Defensin Neutralization

(2010) Jason G. Smith et al.   PLoS Pathogens

Levels of innate immune factors in genital fluids: association of alpha defensins and LL-37 with genital infections and increased HIV acquisition

(2009) Pauline Levinson et al.   AIDS

Retrocyclin 2: a new therapy against avian influenza H5N1 virus in vivo and vitro

(2009) Qing-long Liang et al.   BIOTECHNOLOGY LETTERS

Low concentrations of LL-37 alter IL-8 production by keratinocytes and bronchial epithelial cells in response to proinflammatory stimuli

(2009) Niall C.J. Filewod et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

(2009) Dipyaman Ganguly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human beta-defensin-3 promotes wound healing in infected diabetic wounds

(2009) Tobias Hirsch et al.   JOURNAL OF GENE MEDICINE

Interactions of  -,  -, and  -Defensins with Influenza A Virus and Surfactant Protein D

(2009) M. Doss et al.   JOURNAL OF IMMUNOLOGY

Dying and Necrotic Neutrophils Are Anti-Inflammatory Secondary to the Release of  -Defensins

(2009) K. Miles et al.   JOURNAL OF IMMUNOLOGY

Multivalent Binding of Carbohydrates by the Human  -Defensin, HD5

(2009) R. I. Lehrer et al.   JOURNAL OF IMMUNOLOGY

Defensins in Viral Infections

(2009) Jian Ding et al.   Journal of Innate Immunity

Host-pathogen interactions during coronavirus infection of primary alveolar epithelial cells

(2009) Tanya A. Miura et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages

(2009) Hsin-Ni Li et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Rhesus Theta-Defensin Prevents Death in a Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Pulmonary Disease

(2009) C. L. Wohlford-Lenane et al.   JOURNAL OF VIROLOGY

Enteric defensins are essential regulators of intestinal microbial ecology

(2009) Nita H Salzman et al.   NATURE IMMUNOLOGY

Mechanism of Adenovirus Neutralization by Human α-Defensins

(2008) Jason G. Smith et al.   Cell Host & Microbe

Increased Levels of Human Beta-Defensins mRNA in Sexually HIV-1 Exposed But Uninfected Individuals

(2008) Wildeman Zapata et al.   CURRENT HIV RESEARCH

Antivirals: current state of the art

(2008) Erik De Clercq   Future Virology

Antimicrobial peptides and the skin immune defense system

(2008) Jürgen Schauber et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human α-Defensins Inhibit BK Virus Infection by Aggregating Virions and Blocking Binding to Host Cells

(2008) Aisling S. Dugan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Human β-Defensin-2 during Tumor Necrosis Factor-α/NF-κB-mediated Innate Antiviral Response against Human Respiratory Syncytial Virus

(2008) Srikanth Kota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced expression of murine β-defensins (MBD-1, -2,- 3, and -4) in upper and lower airway mucosa of influenza virus infected mice

(2008) Kong T. Chong et al.   VIROLOGY