Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives

An Unbiased Approach To Identify Endogenous Substrates of “Histone” Deacetylase 8

(2014) David E. Olson et al.   ACS Chemical Biology

Thermodynamics of Binding of Structurally Similar Ligands to Histone Deacetylase 8 Sheds Light on Challenges in the Rational Design of Potent and Isozyme-Selective Inhibitors of the Enzyme

(2014) Raushan K. Singh et al.   BIOCHEMISTRY

Therapeutic potential of histone deacetylase inhibitors in pancreatic cancer

(2014) Wan Feng et al.   CANCER LETTERS

A Plasmodium falciparum Histone Deacetylase Regulates Antigenic Variation and Gametocyte Conversion

(2014) Bradley I. Coleman et al.   Cell Host & Microbe

Small Molecule Control of Chromatin Remodeling

(2014) Aidan Finley et al.   CHEMISTRY & BIOLOGY

Design, Synthesis, and Biological Activity of NCC149 Derivatives as Histone Deacetylase 8-Selective Inhibitors

(2014) Takayoshi Suzuki et al.   ChemMedChem

Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages

(2014) Finn K. Hansen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Inhibitors of Schistosoma mansoni HDAC8 by Combining Homology Modeling, Virtual Screening, and in Vitro Validation

(2014) Srinivasaraghavan Kannan et al.   Journal of Chemical Information and Modeling

New and emerging HDAC inhibitors for cancer treatment

(2014) Alison C. West et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer epigenetics drug discovery and development: the challenge of hitting the mark

(2014) Robert M. Campbell et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a Novel Aminotetralin Class of HDAC6 and HDAC8 Selective Inhibitors

(2014) Guozhi Tang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Basis for the Antiparasitic Activity of a Mercaptoacetamide Derivative That Inhibits Histone Deacetylase 8 (HDAC8) from the Human Pathogen Schistosoma mansoni

(2014) Diana A. Stolfa et al.   JOURNAL OF MOLECULAR BIOLOGY

Epigenetics in health and disease: heralding the EWAS era

(2014) Therese M Murphy et al.   LANCET

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting bromodomains: epigenetic readers of lysine acetylation

(2014) Panagis Filippakopoulos et al.   NATURE REVIEWS DRUG DISCOVERY

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cancer and parasitic infections: similarities and opportunities for the development of new control tools

(2014) Guilherme Oliveira   Revista da Sociedade Brasileira de Medicina Tropical

Epigenetic mechanisms of importance for drug treatment

(2014) Maxim Ivanov et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Epigenetic Changes Modulate Schistosome Egg Formation and Are a Novel Target for Reducing Transmission of Schistosomiasis

(2014) Vitor Coutinho Carneiro et al.   PLoS Pathogens

Epigenetic control of gene function in schistosomes: a source of therapeutic targets?

(2014) Alejandro Cabezas-Cruz et al.   Frontiers in Genetics

Postgraduate training in global health: ensuring UK doctors can contribute to health in resource-poor countries

(2013) C. Brown et al.   CLINICAL MEDICINE

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

(2013) Benjamin E. L. Lauffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loop Interactions and Dynamics Tune the Enzymatic Activity of the Human Histone Deacetylase 8

(2013) Micha B. A. Kunze et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates

(2013) Christopher J. Millard et al.   MOLECULAR CELL

The genomes of four tapeworm species reveal adaptations to parasitism

(2013) Isheng J. Tsai et al.   NATURE

Chromatin modifiers and remodellers: regulators of cellular differentiation

(2013) Taiping Chen et al.   NATURE REVIEWS GENETICS

Regulation of nucleosome dynamics by histone modifications

(2013) Gabriel E Zentner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein lysine acetylation guards metabolic homeostasis to fight against cancer

(2013) W Xu et al.   ONCOGENE

Schistosoma mansoni Sirtuins: Characterization and Potential as Chemotherapeutic Targets

(2013) Julien Lancelot et al.   PLoS Neglected Tropical Diseases

Praziquantel Treatment Decreases Schistosoma mansoni Genetic Diversity in Experimental Infections

(2013) Regina Coeli et al.   PLoS Neglected Tropical Diseases

Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

(2013) Martin Marek et al.   PLoS Pathogens

Hepatic and Intestinal Schistosomiasis: Review

(2013) Tamer Elbaz et al.   Journal of Advanced Research

Expansion of the Lysine Acylation Landscape

(2012) Christian A. Olsen   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Introduction to Theme “Chromatin, Epigenetics, and Transcription”

(2012) Joan W. Conaway   Annual Review of Biochemistry

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Mercaptoacetamide-based class II HDAC inhibitor lowers Aβ levels and improves learning and memory in a mouse model of Alzheimer's disease

(2012) You Me Sung et al.   EXPERIMENTAL NEUROLOGY

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

(2012) Matthew A. Deardorff et al.   NATURE

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Perceiving the epigenetic landscape through histone readers

(2012) Catherine A Musselman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum

(2012) N. A. Malmquist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetics of Host–Pathogen Interactions: The Road Ahead and the Road Behind

(2012) Elena Gómez-Díaz et al.   PLoS Pathogens

Structures, Substrates, and Regulators of Mammalian Sirtuins – Opportunities and Challenges for Drug Development

(2012) Sébastien Moniot et al.   Frontiers in Pharmacology

The Role of Bromodomain Proteins in Regulating Gene Expression

(2012) Gabrielle A. Josling et al.   Genes

Urinary Schistosomiasis: Review

(2012) Rashad S. Barsoum   Journal of Advanced Research

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Chromatin higher-order structures and gene regulation

(2011) Guohong Li et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes

(2011) Patrick M Lombardi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications

(2011) Omar Khan et al.   IMMUNOLOGY AND CELL BIOLOGY

Structural Basis of the Antiproliferative Activity of Largazole, a Depsipeptide Inhibitor of the Histone Deacetylases

(2011) Kathryn E. Cole et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Towards an understanding of the epigenetics of schistosomes: a comparative epigenomic study

(2011) Julie Mireille Joé Lepesant et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Praziquantel and Schistosomiasis

(2010) Alexander Dömling et al.   ChemMedChem

Schistosoma mansoni Polo-like kinase 1: A mitotic kinase with key functions in parasite reproduction☆

(2010) Thavy Long et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

Chromatin structure and the inheritance of epigenetic information

(2010) Raphaël Margueron et al.   NATURE REVIEWS GENETICS

Piggy-backing the concept of cancer drugs for schistosomiasis treatment: a tangible perspective?

(2010) Colette Dissous et al.   TRENDS IN PARASITOLOGY

Histone deacetylase HDAC1/HDAC2-controlled embryonic development and cell differentiation

(2009) Reinhard Brunmeir et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Histone Deacetylase Inhibitors in Cancer Therapy

(2009) Andrew A. Lane et al.   JOURNAL OF CLINICAL ONCOLOGY

Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites

(2009) Alexandre Bougdour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni

(2009) Florence Dubois et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Polo-Like Kinase (PLK) Inhibitors in Preclinical and Early Clinical Development in Oncology

(2009) P. Schoffski   ONCOLOGIST

Helminths and malignancy

(2009) B. J. VENNERVALD et al.   PARASITE IMMUNOLOGY

Epigenetics: molecular mechanisms and implications for disease

(2009) Adam E. Handel et al.   TRENDS IN MOLECULAR MEDICINE

Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening

(2009) Maha-Hamadien Abdulla et al.   PLoS Neglected Tropical Diseases

The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni

(2008) Frédérik Oger et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis

(2008) Michael J Doenhoff et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Schistosoma mansoni: Developmental arrest of miracidia treated with histone deacetylase inhibitors

(2008) A. Azzi et al.   EXPERIMENTAL PARASITOLOGY

Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain

(2008) Matthew J. Bottomley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

(2008) Anja Schuetz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

(2008) S Balasubramanian et al.   LEUKEMIA