Perceiving the epigenetic landscape through histone readers

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

(2012) Panagis Filippakopoulos et al.   CELL

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

(2012) Frédérick A Mallette et al.   EMBO JOURNAL

Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription

(2012) Y. Qiu et al.   GENES & DEVELOPMENT

Structure of C-terminal Tandem BRCT Repeats of Rtt107 Protein Reveals Critical Role in Interaction with Phosphorylated Histone H2A during DNA Damage Repair

(2012) Xinxin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone H3 Lysine 36 Methylation Targets the Isw1b Remodeling Complex to Chromatin

(2012) V. E. Maltby et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres

(2012) Ewa Niedzialkowska et al.   MOLECULAR BIOLOGY OF THE CELL

Structural basis for recognition of H3K56-acetylated histone H3–H4 by the chaperone Rtt106

(2012) Dan Su et al.   NATURE

The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome

(2012) Alex J. Kuo et al.   NATURE

LEDGF (p75) promotes DNA-end resection and homologous recombination

(2012) Mads Daugaard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

(2012) Valentina Migliori et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange

(2012) Michaela Smolle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal Structure of TDRD3 and Methyl-Arginine Binding Characterization of TDRD3, SMN and SPF30

(2012) Ke Liu et al.   PLoS One

Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1

(2012) K. Arita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression

(2012) C. A. Musselman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Recognition of H3T3ph and Smac/DIABLO N-terminal Peptides by Human Survivin

(2012) Jiamu Du et al.   STRUCTURE

A Quantitative, High-Throughput Reverse Genetic Screen Reveals Novel Connections between Pre–mRNA Splicing and 5′ and 3′ End Transcript Determinants

(2012) Laura-Oana Albulescu et al.   PLoS Genetics

Application of Celluspots peptide arrays for the analysis of the binding specificity of epigenetic reading domains to modified histone tails

(2011) Ina Bock et al.   BMC BIOCHEMISTRY

A Poised Chromatin Platform for TGF-β Access to Master Regulators

(2011) Qiaoran Xi et al.   CELL

Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions

(2011) Alexander J. Ruthenburg et al.   CELL

Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger

(2011) Chengkun Wang et al.   CELL RESEARCH

Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2

(2011) Lulu Hu et al.   CELL RESEARCH

Epigenetic virtues of chromodomains

(2011) Bartlomiej J. Blus et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation

(2011) Chuanbing Bian et al.   EMBO JOURNAL

KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcription

(2011) Liangqi Xie et al.   EMBO JOURNAL

The Double-Bromodomain Proteins Bdf1 and Bdf2 Modulate Chromatin Structure to Regulate S-Phase Stress Response in Schizosaccharomyces pombe

(2011) Mikael V. Garabedian et al.   GENETICS

Recognition of Unmodified Histone H3 by the First PHD Finger of Bromodomain-PHD Finger Protein 2 Provides Insights into the Regulation of Histone Acetyltransferases Monocytic Leukemic Zinc-finger Protein (MOZ) and MOZ-related factor (MORF)

(2011) Su Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plant Homeodomain (PHD) Fingers of CHD4 Are Histone H3-binding Modules with Preference for Unmodified H3K4 and Methylated H3K9

(2011) Robyn E. Mansfield et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation

(2011) Wen Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PHD Finger Recognition of Unmodified Histone H3R2 Links UHRF1 to Regulation of Euchromatic Gene Expression

(2011) Eerappa Rajakumara et al.   MOLECULAR CELL

Chromodomain-Mediated Oligomerization of HP1 Suggests a Nucleosome-Bridging Mechanism for Heterochromatin Assembly

(2011) Daniele Canzio et al.   MOLECULAR CELL

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

(2011) Frank W. Schmitges et al.   MOLECULAR CELL

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Deciphering arginine methylation: Tudor tells the tale

(2011) Chen Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcriptional and epigenetic mechanisms of addiction

(2011) Alfred J. Robison et al.   NATURE REVIEWS NEUROSCIENCE

Recognition of enhancer element–specific histone methylation by TIP60 in transcriptional activation

(2011) Kwang Won Jeong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins

(2011) Konstantinos Tripsianes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome

(2011) Shigeki Iwase et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin

(2011) Sebastian Eustermann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Handpicking epigenetic marks with PHD fingers

(2011) C. A. Musselman et al.   NUCLEIC ACIDS RESEARCH

Structural and Histone Binding Ability Characterizations of Human PWWP Domains

(2011) Hong Wu et al.   PLoS One

Structural Basis for the Recognition of Phosphorylated Histone H3 by the Survivin Subunit of the Chromosomal Passenger Complex

(2011) A. Arockia Jeyaprakash et al.   STRUCTURE

Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation

(2010) Till Bartke et al.   CELL

Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers

(2010) Michiel Vermeulen et al.   CELL

Influence of Combinatorial Histone Modifications on Antibody and Effector Protein Recognition

(2010) Stephen M. Fuchs et al.   CURRENT BIOLOGY

γH2A binds Brc1 to maintain genome integrity during S-phase

(2010) Jessica S Williams et al.   EMBO JOURNAL

A cooperative activation loop among SWI/SNF, γ-H2AX and H3 acetylation for DNA double-strand break repair

(2010) Han-Sae Lee et al.   EMBO JOURNAL

BRCT Domain Interactions with Phospho-Histone H2A Target Crb2 to Chromatin at Double-Strand Breaks and Maintain the DNA Damage Checkpoint

(2010) S. Sofueva et al.   MOLECULAR AND CELLULAR BIOLOGY

TDRD3 Is an Effector Molecule for Arginine-Methylated Histone Marks

(2010) Yanzhong Yang et al.   MOLECULAR CELL

Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b

(2010) Lei Zeng et al.   NATURE

TRIM24 links a non-canonical histone signature to breast cancer

(2010) Wen-Wei Tsai et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

Combinatorial profiling of chromatin binding modules reveals multisite discrimination

(2010) Adam L Garske et al.   Nature Chemical Biology

Translation of the phosphoinositide code by PI effectors

(2010) Tatiana G Kutateladze   Nature Chemical Biology

Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1

(2010) Alessandro Vezzoli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain

(2010) Daesung Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)

(2010) C. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Signals of Epigenetic States

(2010) Roberto Bonasio et al.   SCIENCE

Regulation of Alternative Splicing by Histone Modifications

(2010) R. F. Luco et al.   SCIENCE

Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis

(2010) Fangwei Wang et al.   SCIENCE

Structural Insight into the Zinc Finger CW Domain as a Histone Modification Reader

(2010) Fahu He et al.   STRUCTURE

Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications

(2009) Catherine A. Musselman et al.   BIOCHEMICAL JOURNAL

Histone Crosstalk between H3S10ph and H4K16ac Generates a Histone Code that Mediates Transcription Elongation

(2009) Alessio Zippo et al.   CELL

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

ING4 Mediates Crosstalk between Histone H3 K4 Trimethylation and H3 Acetylation to Attenuate Cellular Transformation

(2009) Tiffany Hung et al.   MOLECULAR CELL

HBO1 HAT Complexes Target Chromatin throughout Gene Coding Regions via Multiple PHD Finger Interactions with Histone H3 Tail

(2009) Nehmé Saksouk et al.   MOLECULAR CELL

Interaction of Transcriptional Regulators with Specific Nucleosomes across the Saccharomyces Genome

(2009) R. Thomas Koerber et al.   MOLECULAR CELL

Regulation of Set9-Mediated H4K20 Methylation by a PWWP Domain Protein

(2009) Yu Wang et al.   MOLECULAR CELL

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

(2009) Peter J. Cook et al.   NATURE

Role of the polycomb protein EED in the propagation of repressive histone marks

(2009) Raphael Margueron et al.   NATURE

Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

(2009) Jeanne Morinière et al.   NATURE

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

(2009) John R Horton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

(2009) Quan Zhao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2

(2009) Yahong Guo et al.   NUCLEIC ACIDS RESEARCH

The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation

(2009) Francesca Chignola et al.   NUCLEIC ACIDS RESEARCH

H3 K36 Methylation Helps Determine the Timing of Cdc45 Association with Replication Origins

(2009) Fiona Pryde et al.   PLoS One

Epigenome Microarray Platform for Proteome-Wide Dissection of Chromatin-Signaling Networks

(2009) Dennis J. Bua et al.   PLoS One

A Sequence Motif within Chromatin Entry Sites Directs MSL Establishment on the Drosophila X Chromosome

(2008) Artyom A. Alekseyenko et al.   CELL

The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity

(2008) K. Laue et al.   DEVELOPMENT

Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex

(2008) M. Lange et al.   GENES & DEVELOPMENT

A Role for Chd1 and Set2 in Negatively Regulating DNA Replication in Saccharomyces cerevisiae

(2008) D. Biswas et al.   GENETICS

14-3-3 Interaction with Histone H3 Involves a Dual Modification Pattern of Phosphoacetylation

(2008) W. Walter et al.   MOLECULAR AND CELLULAR BIOLOGY

The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules

(2008) Robert E Collins et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis for the Recognition of Methylated Histone H3K36 by the Eaf3 Subunit of Histone Deacetylase Complex Rpd3S

(2008) Chao Xu et al.   STRUCTURE

A SPOT on the chromatin landscape? Histone peptide arrays as a tool for epigenetic research

(2008) Nataliya Nady et al.   TRENDS IN BIOCHEMICAL SCIENCES