Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

Chromatin regulation in schistosomes and histone modifying enzymes as drug targets

(2014) Raymond John Pierce et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Schistosomiasis

(2013) C. Conlon et al.   CLINICAL MEDICINE

The genomes of four tapeworm species reveal adaptations to parasitism

(2013) Isheng J. Tsai et al.   NATURE

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Design, Synthesis, and Biological Evaluation of 2-Aminobenzanilide Derivatives as Potent and Selective HDAC Inhibitors

(2012) Diana A. Stolfa et al.   ChemMedChem

Decitabine for acute myeloid leukemia

(2012) Peter W Marks   Expert Review of Anticancer Therapy

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

(2012) Matthew A. Deardorff et al.   NATURE

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Phase II trial of the histone deacetylase inhibitor romidepsin in patients with recurrent/metastatic head and neck cancer

(2012) Missak Haigentz et al.   ORAL ONCOLOGY

Romidepsin: A Guide to its Clinical Use in Cutaneous T-Cell Lymphoma

(2011) Katherine A. Lyseng-Williamson et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Cancer Chemoprevention by Targeting the Epigenome

(2011) Joseph Huang et al.   CURRENT DRUG TARGETS

Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes

(2011) Patrick M Lombardi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

HDAC inhibitors in parasitic diseases

(2011) Katherine T Andrews et al.   IMMUNOLOGY AND CELL BIOLOGY

Deciphering correct strategies for multiprotein complex assembly by co-expression: Application to complexes as large as the histone octamer

(2011) Marie-Laure Diebold et al.   JOURNAL OF STRUCTURAL BIOLOGY

Targeting the epigenome for treatment of cancer

(2011) E-J Geutjes et al.   ONCOGENE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Genetic Consequences of Mass Human Chemotherapy for Schistosoma mansoni: Population Structure Pre- and Post-Praziquantel Treatment in Tanzania

(2010) Alice J. Norton et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components

(2010) Nicole C. Wheatley et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

(2010) Jerome C. Bressi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Praziquantel and Schistosomiasis

(2010) Alexander Dömling et al.   ChemMedChem

Epigenetic modifications as therapeutic targets

(2010) Theresa K Kelly et al.   NATURE BIOTECHNOLOGY

Chemical phylogenetics of histone deacetylases

(2010) James E Bradner et al.   Nature Chemical Biology

“Manifesto” for Advancing the Control and Elimination of Neglected Tropical Diseases

(2010) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

Parasites and poverty: The case of schistosomiasis

(2009) Charles H. King   ACTA TROPICA

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Histone Deacetylase Inhibitors in Cancer Therapy

(2009) Andrew A. Lane et al.   JOURNAL OF CLINICAL ONCOLOGY

Identification and Characterization of Small Molecule Inhibitors of a Class I Histone Deacetylase fromPlasmodium falciparum

(2009) Vishal Patel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni

(2009) Florence Dubois et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Helminths and malignancy

(2009) B. J. VENNERVALD et al.   PARASITE IMMUNOLOGY

Potent Antimalarial Activity of Histone Deacetylase Inhibitor Analogues

(2008) K. T. Andrews et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni

(2008) Frédérik Oger et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy

(2008) Prasenjit Mukherjee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pyridylalanine-Containing Hydroxamic Acids as Selective HDAC6 Inhibitors

(2008) Stefan Schäfer et al.   ChemMedChem

Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis

(2008) Michael J Doenhoff et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

(2008) Anja Schuetz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

(2008) S Balasubramanian et al.   LEUKEMIA