Tetramer formation of tumor suppressor protein p53: Structure, function, and applications

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding

(2015) GuoZhen Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and characterization of the gD protein of HSV-2 fused to the tetramerization domain of the transcription factor p53

(2015) M. Pérez-Hernández et al.   PROTEIN EXPRESSION AND PURIFICATION

Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53

(2015) K. W. Yoon et al.   SCIENCE

Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression

(2015) Fabio Valenti et al.   Oncotarget

PRMT5 enhances generation of induced pluripotent stem cells from dairy goat embryonic fibroblastsviadown-regulation of p53

(2014) Z. Chu et al.   CELL PROLIFERATION

Effects of biomineralization peptide topology on the structure and catalytic activity of Pd nanomaterials

(2014) Jose Isagani B. Janairo et al.   CHEMICAL COMMUNICATIONS

GermlineTP53Mutations and the Changing Landscape of Li-Fraumeni Syndrome

(2014) Junne Kamihara et al.   HUMAN MUTATION

The E3 Ubiquitin Protein Ligase HERC2 Modulates the Activity of Tumor Protein p53 by Regulating Its Oligomerization

(2014) Monica Cubillos-Rojas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity

(2014) Valérie Lang et al.   Molecular Oncology

Constant rate of p53 tetramerization in response to DNA damage controls the p53 response

(2014) G. Gaglia et al.   Molecular Systems Biology

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Tracing the Evolution of the p53 Tetramerization Domain

(2014) Andreas C. Joerger et al.   STRUCTURE

New insights into p53 functions through its target microRNAs

(2014) J.-M. Liao et al.   Journal of Molecular Cell Biology

Late Cornified Envelope Group I, a Novel Target of p53, Regulates PRMT5 Activity

(2014) Zhenzhong Deng et al.   NEOPLASIA

The Nucleolar Protein Myb-binding Protein 1A (MYBBP1A) Enhances p53 Tetramerization and Acetylation in Response to Nucleolar Disruption

(2013) Wakana Ono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Chimeric p53 Evades Mutant p53 Transdominant Inhibition in Cancer Cells

(2013) Abood Okal et al.   MOLECULAR PHARMACEUTICS

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

High Frequency of Germline TP53 Mutations in a Prospective Adult-Onset Sarcoma Cohort

(2013) Gillian Mitchell et al.   PLoS One

Activation and control of p53 tetramerization in individual living cells

(2013) G. Gaglia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional self-assembling polypeptide bionanomaterials

(2012) Tibor Doles et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Tetramer of p53 in the Absence of DNA Forms a Relaxed Quaternary State

(2012) Nam Pham et al.   BIOCHEMISTRY

Inhibition of tumor suppressor protein p53-dependent transcription by a tetramerization domain peptide via hetero-oligomerization

(2012) Junya Wada et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The rebel angel: mutant p53 as the driving oncogene in breast cancer

(2012) D. Walerych et al.   CARCINOGENESIS

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

The Regulatory Domain Stabilizes the p53 Tetramer by Intersubunit Contacts with the DNA Binding Domain

(2012) Marco Retzlaff et al.   JOURNAL OF MOLECULAR BIOLOGY

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis

(2012) Bernard Leroy et al.   NUCLEIC ACIDS RESEARCH

Probing phenylalanine environments in oligomeric structures with pentafluorophenylalanine and cyclohexylalanine

(2011) Takao Nomura et al.   BIOPOLYMERS

On the Role of Flexibility in Protein-Ligand Interactions: the Example of p53 Tetramerization Domain

(2011) Susana Gordo et al.   Chemistry-An Asian Journal

Peptide-Based Methods for the Preparation of Nanostructured Inorganic Materials

(2010) Chun-Long Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nitration of the Tumor Suppressor Protein p53 at Tyrosine 327 Promotes p53 Oligomerization and Activation

(2010) Vasily A. Yakovlev et al.   BIOCHEMISTRY

Enhancement of transcriptional activity of mutant p53 tumor suppressor protein through stabilization of tetramer formation by calix[6]arene derivatives

(2010) Rui Kamada et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Characterization of a new cancer-associated mutant of p53 with a missense mutation (K351N) in the tetramerization domain

(2010) Michela Muscolini et al.   CELL CYCLE

p53 and NF-κB: different strategies for responding to stress lead to a functional antagonism

(2010) Prashanth Ak et al.   FASEB JOURNAL

Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation

(2010) Roland Hjerpe et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cancer-associated p53 Tetramerization Domain Mutants

(2010) Rui Kamada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

LI-FRAUMENI SYNDROME IN A TURKISH FAMILY

(2010) Zeynep Karakas et al.   PEDIATRIC HEMATOLOGY AND ONCOLOGY

Backbone dynamics of the oligomerization domain of p53 determined from 15N NMR relaxation measurements

(2010) Robert T. Clubb et al.   PROTEIN SCIENCE

p53 and stem cells: new developments and new concerns

(2010) Tongbiao Zhao et al.   TRENDS IN CELL BIOLOGY

p53 post-translational modification: deregulated in tumorigenesis

(2010) Chao Dai et al.   TRENDS IN MOLECULAR MEDICINE

The Tumor Suppressor p53: From Structures to Drug Discovery

(2010) A. C. Joerger et al.   Cold Spring Harbor Perspectives in Biology

Evaluation of transcriptional activity of p53 in individual living mammalian cells

(2009) Toshiaki Imagawa et al.   ANALYTICAL BIOCHEMISTRY

A Peptide-Based Dendrimer That Enhances the Splice-Redirecting Activity of PNA Conjugates in Cells

(2009) Fatouma Said Hassane et al.   BIOCONJUGATE CHEMISTRY

Conservation of DNA-binding specificity and oligomerisation properties within the p53 family

(2009) Tobias Brandt et al.   BMC GENOMICS

Conformational stability and activity of p73 require a second helix in the tetramerization domain

(2009) D Coutandin et al.   CELL DEATH AND DIFFERENTIATION

Modulation of the Oligomerization State of p53 by Differential Binding of Proteins of the S100 Family to p53 Monomers and Tetramers

(2009) Jan van Dieck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 Attenuates Lipopolysaccharide-Induced NF- B Activation and Acute Lung Injury

(2009) G. Liu et al.   JOURNAL OF IMMUNOLOGY

Folding of Tetrameric p53: Oligomerization and Tumorigenic Mutations Induce Misfolding and Loss of Function

(2009) David J. Lubin et al.   JOURNAL OF MOLECULAR BIOLOGY

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

PRMT5 is required for cell-cycle progression and p53 tumor suppressor function

(2009) A. Scoumanne et al.   NUCLEIC ACIDS RESEARCH

Ultraslow oligomerization equilibria of p53 and its implications

(2009) E. Natan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural evolution of p53, p63, and p73: Implication for heterotetramer formation

(2009) A. C. Joerger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

Structural Biology of the Tumor Suppressor p53

(2008) Andreas C. Joerger et al.   Annual Review of Biochemistry

Oxidation of methionine residue at hydrophobic core destabilizes p53 tetrameric structure

(2008) Takao Nomura et al.   BIOPOLYMERS

A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis

(2008) L Weinmann et al.   CELL DEATH AND DIFFERENTIATION

Protein- and Peptide-Directed Syntheses of Inorganic Materials

(2008) Matthew B. Dickerson et al.   CHEMICAL REVIEWS

Soft-shell clam (Mya arenaria) p53: A structural and functional comparison to human p53

(2008) Lauren A.C. Holbrook et al.   GENE

p53 Oligomerization Is Essential for Its C-terminal Lysine Acetylation

(2008) Yoko Itahana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis of Pirh2-mediated p53 ubiquitylation

(2008) Yi Sheng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers

(2008) S. Rajagopalan et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of a p53 core tetramer bound to DNA

(2008) K A Malecka et al.   ONCOGENE

Stability and structural recovery of the tetramerization domain of p53-R337H mutant induced by a designed templating ligand

(2008) S. Gordo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA