Novel treatment strategies and drugs in development for cryptosporidiosis

Discovery of ebselen as an inhibitor of Cryptosporidium parvum glucose-6-phosphate isomerase (CpGPI) by high-throughput screening of existing drugs

(2018) Rana Eltahan et al.   International Journal for Parasitology-Drugs and Drug Resistance

Atorvastatin repurposing for the treatment of cryptosporidiosis in experimentally immunosuppressed mice

(2017) Noha Madbouly Taha et al.   EXPERIMENTAL PARASITOLOGY

Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection

(2017) Samuel L. M. Arnold et al.   JOURNAL OF INFECTIOUS DISEASES

Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy

(2017) Matthew A. Hulverson et al.   JOURNAL OF INFECTIOUS DISEASES

Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Disease Study 2015

(2017) Christopher Troeger et al.   LANCET INFECTIOUS DISEASES

Design and Solidification of Fast-Releasing Clofazimine Nanoparticles for Treatment of Cryptosporidiosis

(2017) Yingyue Zhang et al.   MOLECULAR PHARMACEUTICS

A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis

(2017) Ujjini H. Manjunatha et al.   NATURE

Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis

(2017) Vitul Jain et al.   STRUCTURE

Cryptosporidium spp. Infection in Solid Organ Transplantation

(2017) Fanny Lanternier et al.   TRANSPLANTATION

A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis

(2017) Melissa S. Love et al.   PLoS Neglected Tropical Diseases

The therapeutic efficacy of azithromycin and nitazoxanide in the acute pig model of Cryptosporidium hominis

(2017) Sangun Lee et al.   PLoS One

Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase

(2016) Andrés Palencia et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Novel Calcium-Dependent Kinase Inhibitor, Bumped Kinase Inhibitor 1517, Cures Cryptosporidiosis in Immunosuppressed Mice

(2016) Alejandro Castellanos-Gonzalez et al.   JOURNAL OF INFECTIOUS DISEASES

Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis

(2016) Deborah A. Schaefer et al.   JOURNAL OF INFECTIOUS DISEASES

The Burden of Cryptosporidium Diarrheal Disease among Children < 24 Months of Age in Moderate/High Mortality Regions of Sub-Saharan Africa and South Asia, Utilizing Data from the Global Enteric Multicenter Study (GEMS)

(2016) Samba O. Sow et al.   PLoS Neglected Tropical Diseases

Inhibition of Calcium-Dependent Protein Kinase 1 (CDPK1)In Vitroby Pyrazolopyrimidine Derivatives Does Not Correlate with Sensitivity of Cryptosporidium parvum Growth in Cell Culture

(2015) Theresa B. Kuhlenschmidt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A nanotherapy strategy significantly enhances anticryptosporidial activity of an inhibitor of bifunctional thymidylate synthase-dihydrofolate reductase from Cryptosporidium

(2015) Anindita Mukerjee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Target validation of the inosine monophosphate dehydrogenase (IMPDH) gene in Cryptosporidium using Phylomer® peptides

(2015) R. Jefferies et al.   EXPERIMENTAL PARASITOLOGY

Preassembled Single-Stranded RNA–Argonaute Complexes: A Novel Method to Silence Genes inCryptosporidium

(2015) Alejandro Castellanos-Gonzalez et al.   JOURNAL OF INFECTIOUS DISEASES

A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium

(2015) William Checkley et al.   LANCET INFECTIOUS DISEASES

Cryptosporidiuminfection after renal transplantation in an endemic area

(2015) D. Bhadauria et al.   Transplant Infectious Disease

A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments

(2015) Christopher D. Huston et al.   PLoS Neglected Tropical Diseases

Oleylphosphocholine (OlPC) arrests Cryptosporidium parvum growth in vitro and prevents lethal infection in interferon gamma receptor knock-out mice

(2015) Karine Sonzogni-Desautels et al.   Frontiers in Microbiology

Therapeutic effects of acetylspiramycin and garlicin on cryptosporidiosis among drug users

(2015) Min-Zhu Huang et al.   International Journal for Parasitology-Drugs and Drug Resistance

Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED)

(2015) James A Platts-Mills et al.   Lancet Global Health

Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase–dihydrofolate reductase

(2014) Vidya P. Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel CDPK1 inhibitor—a potential treatment for cryptosporidiosis in calves?

(2014) Matthias Lendner et al.   PARASITOLOGY RESEARCH

Direct Comparison of the Efficacy and Safety of Oral Treatments with Oleylphosphocholine (OlPC) and Miltefosine in a Mouse Model of L. major Cutaneous Leishmaniasis

(2014) Anny Fortin et al.   PLoS Neglected Tropical Diseases

Validation of IMP Dehydrogenase Inhibitors in a Mouse Model of Cryptosporidiosis

(2013) Suresh Kumar Gorla et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Cysteine Protease Inhibitor Rescues Mice from a Lethal Cryptosporidium parvum Infection

(2013) Momar Ndao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Drug Repurposing Screen Reveals FDA-Approved Inhibitors of Human HMG-CoA Reductase and Isoprenoid Synthesis That Block Cryptosporidium parvum Growth

(2013) Kovi Bessoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cryptosporidium parvumscavenges LDL-derived cholesterol and micellar cholesterol internalized into enterocytes

(2013) Karen Ehrenman et al.   CELLULAR MICROBIOLOGY

Amelioration of Cryptosporidium parvum Infection In Vitro and In Vivo by Targeting Parasite Fatty Acyl-Coenzyme A Synthetases

(2013) F. Guo et al.   JOURNAL OF INFECTIOUS DISEASES

A Novel Calcium-Dependent Protein Kinase Inhibitor as a Lead Compound for Treating Cryptosporidiosis

(2013) Alejandro Castellanos-Gonzalez et al.   JOURNAL OF INFECTIOUS DISEASES

Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

(2013) Karen L Kotloff et al.   LANCET

Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis

(2012) T. P. C. Dorlo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In a trial of the use of miltefosine to treat HIV‐related cryptosporidiosis in Zambian adults, extreme metabolic disturbances contribute to high mortality

(2011) E Sinkala et al.   ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY

The loading of labelled antibody-engineered nanoparticles with Indinavir increases its in vitro efficacy against Cryptosporidium parvum

(2011) L. BONDIOLI et al.   PARASITOLOGY

Cryptosporidiosis and the Ears of the Hippopotamus

(2010) A. Clinton White et al.   CLINICAL INFECTIOUS DISEASES

Respiratory Cryptosporidiosis in HIV‐Seronegative Children in Uganda: Potential for Respiratory Transmission

(2010) Siobhan M. Mor et al.   CLINICAL INFECTIOUS DISEASES

Treatment of cryptosporidiosis: do we know what we think we know?

(2010) Miguel M Cabada et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii

(2010) Ryan C. Murphy et al.   ACS Medicinal Chemistry Letters

High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: a randomised controlled trial

(2009) Beatrice Amadi et al.   BMC INFECTIOUS DISEASES