A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments

Comparison of four rapid diagnostic tests, ELISA, microscopy and PCR for the detection of Giardia lamblia, Cryptosporidium spp. and Entamoeba histolytica in feces

(2015) Dorien Van den Bossche et al.   JOURNAL OF MICROBIOLOGICAL METHODS

A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium

(2015) William Checkley et al.   LANCET INFECTIOUS DISEASES

Identification of Cryptosporidium parvum Active Chemical Series by Repurposing the Open Access Malaria Box

(2014) K. Bessoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Validation of IMP Dehydrogenase Inhibitors in a Mouse Model of Cryptosporidiosis

(2013) Suresh Kumar Gorla et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Cysteine Protease Inhibitor Rescues Mice from a Lethal Cryptosporidium parvum Infection

(2013) Momar Ndao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Drug Repurposing Screen Reveals FDA-Approved Inhibitors of Human HMG-CoA Reductase and Isoprenoid Synthesis That Block Cryptosporidium parvum Growth

(2013) Kovi Bessoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multicentric Evaluation of a New Real-Time PCR Assay for Quantification of Cryptosporidium spp. and Identification of Cryptosporidium parvum and Cryptosporidium hominis

(2013) C. Mary et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Amelioration of Cryptosporidium parvum Infection In Vitro and In Vivo by Targeting Parasite Fatty Acyl-Coenzyme A Synthetases

(2013) F. Guo et al.   JOURNAL OF INFECTIOUS DISEASES

A Novel Calcium-Dependent Protein Kinase Inhibitor as a Lead Compound for Treating Cryptosporidiosis

(2013) Alejandro Castellanos-Gonzalez et al.   JOURNAL OF INFECTIOUS DISEASES

Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase

(2013) Suresh Kumar Gorla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

(2013) Karen L Kotloff et al.   LANCET

Antimalarial drug discovery – the path towards eradication

(2013) JEREMY N BURROWS et al.   PARASITOLOGY

Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1

(2012) Zhongsheng Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure–activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH

(2012) Sivapriya Kirubakaran et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Burden of disease from cryptosporidiosis

(2012) Debbie-Ann T. Shirley et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Novel In Vitro and In Vivo Models and Potential New Therapeutics to Break the Vicious Cycle of Cryptosporidium Infection and Malnutrition

(2012) Lourrany B. Costa et al.   JOURNAL OF INFECTIOUS DISEASES

Age specific aetiological agents of diarrhoea in hospitalized children aged less than five years in Dar es Salaam, Tanzania

(2011) Sabrina J Moyo et al.   BMC Pediatrics

Novel anti-Cryptosporidium activity of known drugs identified by high-throughput screening against parasite fatty acyl-CoA binding protein (ACBP)

(2011) J. M. Fritzler et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Cryptosporidium-Malnutrition Interactions: Mucosal Disruption, Cytokines, and TLR Signaling In A Weaned Murine Model

(2011) Lourrany B Costa et al.   JOURNAL OF PARASITOLOGY

Dual probe DNA capture for sensitive real-time PCR detection of Cryptosporidium and Giardia

(2011) Suzanne Stroup et al.   MOLECULAR AND CELLULAR PROBES

Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii

(2010) Ryan C. Murphy et al.   ACS Medicinal Chemistry Letters

High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: a randomised controlled trial

(2009) Beatrice Amadi et al.   BMC INFECTIOUS DISEASES

Effect of nitazoxanide on cryptosporidiosis in experimentally infected neonatal dairy calves

(2009) T.L. Ollivett et al.   JOURNAL OF DAIRY SCIENCE

Triazole Inhibitors ofCryptosporidium parvumInosine 5′-Monophosphate Dehydrogenase

(2009) Sushil K. Maurya et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting a Prokaryotic Protein in a Eukaryotic Pathogen: Identification of Lead Compounds against Cryptosporidiosis

(2008) Nwakaso N. Umejiego et al.   CHEMISTRY & BIOLOGY

Cryptosporidiosis in Children in Sub‐Saharan Africa: A Lingering Challenge

(2008) Siobhan M. Mor et al.   CLINICAL INFECTIOUS DISEASES