Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis

(2016) Rama Subba Rao Vidadala et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bumped kinase inhibitor prohibits egression in Babesia bovis

(2016) Monica J. Pedroni et al.   VETERINARY PARASITOLOGY

A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium

(2015) William Checkley et al.   LANCET INFECTIOUS DISEASES

Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum

(2015) Sumiti Vinayak et al.   NATURE

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1

(2015) Wenlin Huang et al.   ACS Medicinal Chemistry Letters

Bumped Kinase Inhibitor 1294 Treats Established Toxoplasma gondii Infection

(2014) J. Stone Doggett et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes

(2014) Rama Subba Rao Vidadala et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The gatekeeper residue and beyond: homologous calcium-dependent protein kinases as drug development targets for veterinarian Apicomplexa parasites

(2014) KATELYN R. KEYLOUN et al.   PARASITOLOGY

A novel CDPK1 inhibitor—a potential treatment for cryptosporidiosis in calves?

(2014) Matthias Lendner et al.   PARASITOLOGY RESEARCH

Validation of IMP Dehydrogenase Inhibitors in a Mouse Model of Cryptosporidiosis

(2013) Suresh Kumar Gorla et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Novel Calcium-Dependent Protein Kinase Inhibitor as a Lead Compound for Treating Cryptosporidiosis

(2013) Alejandro Castellanos-Gonzalez et al.   JOURNAL OF INFECTIOUS DISEASES

Substituted 2-Phenylimidazopyridines: A New Class of Drug Leads for Human African Trypanosomiasis

(2013) Hari Babu Tatipaka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

(2013) Karen L Kotloff et al.   LANCET

Description of fecal shedding of Cryptosporidium parvum oocysts in experimentally challenged dairy calves

(2013) Jennifer A. Zambriski et al.   PARASITOLOGY RESEARCH

Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold

(2013) Zhongsheng Zhang et al.   ACS Medicinal Chemistry Letters

Burden of disease from cryptosporidiosis

(2012) Debbie-Ann T. Shirley et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors

(2012) Kayode K. Ojo et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitors with Potent Anti-Toxoplasma Activity

(2012) Steven M. Johnson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antibody fusions reduce onset of experimental Cryptosporidium parvum infection in calves

(2012) Michael Imboden et al.   VETERINARY PARASITOLOGY

Antibodies Fused to Innate Immune Molecules Reduce Initiation of Cryptosporidium parvum Infection in Mice

(2010) M. Imboden et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Treatment of cryptosporidiosis: do we know what we think we know?

(2010) Miguel M Cabada et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Cryptosporidiosis in Neonatal Calves

(2010) Carol R. Wyatt et al.   VETERINARY CLINICS OF NORTH AMERICA-FOOD ANIMAL PRACTICE

Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii

(2010) Ryan C. Murphy et al.   ACS Medicinal Chemistry Letters

High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: a randomised controlled trial

(2009) Beatrice Amadi et al.   BMC INFECTIOUS DISEASES

Effect of nitazoxanide on cryptosporidiosis in experimentally infected neonatal dairy calves

(2009) T.L. Ollivett et al.   JOURNAL OF DAIRY SCIENCE

Systematic review and meta-analyses of the effects of halofuginone against calf cryptosporidiosis

(2009) Charlotte Silverlås et al.   PREVENTIVE VETERINARY MEDICINE

A hundred-year retrospective on cryptosporidiosis

(2008) Saul Tzipori et al.   TRENDS IN PARASITOLOGY

Prophylactic and therapeutic efficacy of nitazoxanide against Cryptosporidium parvum in experimentally challenged neonatal calves

(2008) M. Schnyder et al.   VETERINARY PARASITOLOGY