Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy

A Novel Calcium-Dependent Kinase Inhibitor, Bumped Kinase Inhibitor 1517, Cures Cryptosporidiosis in Immunosuppressed Mice

(2016) Alejandro Castellanos-Gonzalez et al.   JOURNAL OF INFECTIOUS DISEASES

Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis

(2016) Deborah A. Schaefer et al.   JOURNAL OF INFECTIOUS DISEASES

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis

(2016) Rama Subba Rao Vidadala et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of Calcium-Dependent Protein Kinase 1 (CDPK1)In Vitroby Pyrazolopyrimidine Derivatives Does Not Correlate with Sensitivity of Cryptosporidium parvum Growth in Cell Culture

(2015) Theresa B. Kuhlenschmidt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Preassembled Single-Stranded RNA–Argonaute Complexes: A Novel Method to Silence Genes inCryptosporidium

(2015) Alejandro Castellanos-Gonzalez et al.   JOURNAL OF INFECTIOUS DISEASES

A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium

(2015) William Checkley et al.   LANCET INFECTIOUS DISEASES

Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum

(2015) Sumiti Vinayak et al.   NATURE

Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED)

(2015) James A Platts-Mills et al.   Lancet Global Health

High-risk enteric pathogens associated with HIV infection and HIV exposure in Kenyan children with acute diarrhoea

(2014) Patricia B. Pavlinac et al.   AIDS

Identification of Cryptosporidium parvum Active Chemical Series by Repurposing the Open Access Malaria Box

(2014) K. Bessoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The gatekeeper residue and beyond: homologous calcium-dependent protein kinases as drug development targets for veterinarian Apicomplexa parasites

(2014) KATELYN R. KEYLOUN et al.   PARASITOLOGY

A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation

(2013) Kayode K. Ojo et al.   JOURNAL OF INFECTIOUS DISEASES

A Novel Calcium-Dependent Protein Kinase Inhibitor as a Lead Compound for Treating Cryptosporidiosis

(2013) Alejandro Castellanos-Gonzalez et al.   JOURNAL OF INFECTIOUS DISEASES

Substituted 2-Phenylimidazopyridines: A New Class of Drug Leads for Human African Trypanosomiasis

(2013) Hari Babu Tatipaka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

(2013) Karen L Kotloff et al.   LANCET

Distinct signalling pathways controlToxoplasmaegress and host-cell invasion

(2012) Sebastian Lourido et al.   EMBO JOURNAL

Drug disposition and clinical practice in neonates: Cross talk between developmental physiology and pharmacology

(2012) Anne Smits et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors

(2012) Kayode K. Ojo et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitors with Potent Anti-Toxoplasma Activity

(2012) Steven M. Johnson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

(2012) Joanne Bowes et al.   NATURE REVIEWS DRUG DISCOVERY

Comparison of Human Ether-à-go-go Related Gene Screening Assays Based on IonWorks Quattro and Thallium Flux

(2010) Terry R. Bridal et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma

(2010) Sebastian Lourido et al.   NATURE

Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors

(2010) Kayode K Ojo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii

(2010) Ryan C. Murphy et al.   ACS Medicinal Chemistry Letters

Calcium-Dependent Signaling and Kinases in Apicomplexan Parasites

(2009) Oliver Billker et al.   Cell Host & Microbe