Notch signaling as a therapeutic target for acute lymphoblastic leukemia

The role of CXCL12 in tumor microenvironment

(2018) Wenfang Meng et al.   GENE

The mazy case of Notch and immunoregulatory cells

(2017) Paola Grazioli et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CXCR4 Ligands: The Next Big Hit?

(2017) Annemiek M.E. Walenkamp et al.   JOURNAL OF NUCLEAR MEDICINE

The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia

(2017) Sung Hee Choi et al.   PLoS One

Synergistic antileukemic therapies inNOTCH1-induced T-ALL

(2017) Marta Sanchez-Martin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia

(2017) Mattia Mori et al.   Scientific Reports

Advances in understanding the acute lymphoblastic leukemia bone marrow microenvironment: From biology to therapeutic targeting

(2016) Francesca Chiarini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia

(2016) M. Y. Chiang et al.   BLOOD

Effects of pharmacological and genetic disruption of CXCR4 chemokine receptor function in B-cell acute lymphoblastic leukaemia

(2016) Shubhchintan Randhawa et al.   BRITISH JOURNAL OF HAEMATOLOGY

Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function

(2016) Weihuan Wang et al.   CANCER RESEARCH

PIN1 in breast development and cancer: a clinical perspective

(2016) Alessandra Rustighi et al.   CELL DEATH AND DIFFERENTIATION

Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression

(2016) G Franciosa et al.   ONCOGENE

Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies

(2016) P Bernasconi-Elias et al.   ONCOGENE

MicroRNA-101 regulates T-cell acute lymphoblastic leukemia progression and chemotherapeutic sensitivity by targeting Notch1

(2016) Lu Qian et al.   ONCOLOGY REPORTS

The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling

(2016) C De Ford et al.   Cell Death & Disease

CXCR4 Is Required for Leukemia-Initiating Cell Activity in T Cell Acute Lymphoblastic Leukemia

(2015) Diana Passaro et al.   CANCER CELL

CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance

(2015) Lauren A. Pitt et al.   CANCER CELL

Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency

(2015) W.-C. Yen et al.   CLINICAL CANCER RESEARCH

Molecular Pathways: Targeting the CXCR4-CXCL12 Axis--Untapped Potential in the Tumor Microenvironment

(2015) S. Scala   CLINICAL CANCER RESEARCH

Effect of rMnSOD on Survival Signaling in Pediatric High Risk T-Cell Acute Lymphoblastic Leukaemia

(2015) A. Pica et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Role of Epigenetic Mechanisms in Notch Signaling During Development

(2015) Ralf Schwanbeck   JOURNAL OF CELLULAR PHYSIOLOGY

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

(2015) Shuo Wei et al.   NATURE MEDICINE

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

A Phase 1 study of the novel gamma-secretase inhibitor PF-03084014 in patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma

(2015) C Papayannidis et al.   Blood Cancer Journal

The epigenetic factor BORIS/CTCFL regulates the NOTCH3 gene expression in cancer cells

(2014) Michele Zampieri et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A Jagged Road to Lymphoma Aggressiveness

(2014) Vedran Radojcic et al.   CANCER CELL

DLL4 regulates NOTCH signaling and growth of T acute lymphoblastic leukemia cells in NOD/SCID mice

(2014) Sonia Minuzzo et al.   CARCINOGENESIS

The Molecular Basis of Notch Signaling Regulation: A Complex Simplicity

(2014) R. Palermo et al.   CURRENT MOLECULAR MEDICINE

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

(2014) Alejandro Gutierrez et al.   JOURNAL OF CLINICAL INVESTIGATION

A microRNA-mediated regulatory loop modulates NOTCH and MYC oncogenic signals in B- and T-cell malignancies

(2014) M Ortega et al.   LEUKEMIA

Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia

(2014) V Kumar et al.   LEUKEMIA

Combination of Imatinib with CXCR4 Antagonist BKT140 Overcomes the Protective Effect of Stroma and Targets CML In Vitro and In Vivo

(2014) K. Beider et al.   MOLECULAR CANCER THERAPEUTICS

Cell competition is a tumour suppressor mechanism in the thymus

(2014) Vera C. Martins et al.   NATURE

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

(2014) Panagiotis Ntziachristos et al.   NATURE

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

(2014) Birgit Knoechel et al.   NATURE GENETICS

Notch3/Jagged1 Circuitry Reinforces Notch Signaling and Sustains T-ALL

(2014) Maria Pelullo et al.   NEOPLASIA

DIAGNOSIS AND SUBCLASSIFICATION OF ACUTE LYMPHOBLASTIC LEUKEMIA

(2014) Sabina Chiaretti et al.   Mediterranean Journal of Hematology and Infectious Diseases

Complementary Genomic Screens Identify SERCA as a Therapeutic Target in NOTCH1 Mutated Cancer

(2013) Giovanni Roti et al.   CANCER CELL

Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast

(2013) Alessandra Rustighi et al.   EMBO Molecular Medicine

Relapsed childhood acute lymphoblastic leukaemia

(2013) Deepa Bhojwani et al.   LANCET ONCOLOGY

Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts

(2013) V Agnusdei et al.   LEUKEMIA

Notch inhibitors for cancer treatment

(2013) Ingrid Espinoza et al.   PHARMACOLOGY & THERAPEUTICS

Targeting Notch signaling pathway in cancer: Clinical development advances and challenges

(2013) Naoko Takebe et al.   PHARMACOLOGY & THERAPEUTICS

Epigenetic Inactivation of Notch-Hes Pathway in Human B-Cell Acute Lymphoblastic Leukemia

(2013) Shao-Qing Kuang et al.   PLoS One

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers

(2013) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A review on CXCR4/CXCL12 axis in oncology: No place to hide

(2012) Urszula M. Domanska et al.   EUROPEAN JOURNAL OF CANCER

HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function

(2012) Hiroki Hayashi et al.   FASEB JOURNAL

PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response

(2012) C Shepherd et al.   LEUKEMIA

Preclinical Analysis of the  -Secretase Inhibitor PF-03084014 in Combination with Glucocorticoids in T-cell Acute Lymphoblastic Leukemia

(2012) J. B. Samon et al.   MOLECULAR CANCER THERAPEUTICS

NOTCH1 Nuclear Interactome Reveals Key Regulators of Its Transcriptional Activity and Oncogenic Function

(2012) Ahmad Yatim et al.   MOLECULAR CELL

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

(2012) Panagiotis Ntziachristos et al.   NATURE MEDICINE

Modulating the Strength and Threshold of NOTCH Oncogenic Signals by mir-181a-1/b-1

(2012) Rita Fragoso et al.   PLoS Genetics

Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL

(2011) J. Tatarek et al.   BLOOD

Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells

(2011) A. H. Nwabo Kamdje et al.   BLOOD

Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150

(2011) M. Ghisi et al.   BLOOD

Notch3 and Canonical NF- B Signaling Pathways Cooperatively Regulate Foxp3 Transcription

(2011) A. Barbarulo et al.   JOURNAL OF IMMUNOLOGY

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

(2011) Virginia Guarani et al.   NATURE

Challenging issues in pediatric oncology

(2011) Ching-Hon Pui et al.   Nature Reviews Clinical Oncology

Acetylation controls Notch3 stability and function in T-cell leukemia

(2011) R Palermo et al.   ONCOGENE

Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia

(2010) Maddalena Paganin et al.   BLOOD REVIEWS

A NADPH Oxidase–Dependent Redox Signaling Pathway Mediates the Selective Radiosensitization Effect of Parthenolide in Prostate Cancer Cells

(2010) Yulan Sun et al.   CANCER RESEARCH

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

(2010) Konstantinos J. Mavrakis et al.   NATURE CELL BIOLOGY

Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

(2010) Miguel Aste-Amézaga et al.   PLoS One

Targeting the Notch1 and mTOR pathways in a mouse T-ALL model

(2009) K. Cullion et al.   BLOOD

Expression of CD133 on leukemia-initiating cells in childhood ALL

(2009) C. V. Cox et al.   BLOOD

Inhibition of NOTCH Signaling by Gamma Secretase Inhibitor Engages the RB Pathway and Elicits Cell Cycle Exit in T-Cell Acute Lymphoblastic Leukemia Cells

(2009) S. S. Rao et al.   CANCER RESEARCH

Peptidyl-Prolyl Isomerase Pin1 Markedly Enhances the Oncogenic Activity of the Rel Proteins in the Nuclear Factor- B Family

(2009) G. Fan et al.   CANCER RESEARCH

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Differential subcellular localization regulates c-Cbl E3 ligase activity upon Notch3 protein in T-cell leukemia

(2009) S Checquolo et al.   ONCOGENE

KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract

(2008) Hai Zheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells

(2008) E. Rosati et al.   BLOOD

NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL

(2008) M. L. Sulis et al.   BLOOD

Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3

(2008) Kang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

(2008) Pedro J Real et al.   NATURE MEDICINE