Progress in immune-based therapies for type 1 diabetes

Immunological biomarkers: Catalysts for translational advances in autoimmune diabetes

(2013) S. T. Ahmed et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

(2013) Antoinette Moran et al.   LANCET

Removal of Bovine Insulin From Cow's Milk Formula and Early Initiation of Beta-Cell Autoimmunity in the FINDIA Pilot Study

(2012) Outi Vaarala et al.   ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE

Immune responses against islet allografts during tapering of immunosuppression - a pilot study in 5 subjects

(2012) V. A. L. Huurman et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity

(2012) J. R. F. Abreu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients

(2012) F. K. Gorus et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Up-regulation of fas and fasL pro-apoptotic genes expression in type 1 diabetes patients after autologous haematopoietic stem cell transplantation

(2012) G. L. V. de Oliveira et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Therapeutic manipulation of natural killer (NK) T cells in autoimmunity: are we close to reality?

(2012) Y. Simoni et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Innate and adaptive immune gene expression profiles as biomarkers in human type 1 diabetes

(2012) D. Han et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cell-based interventions to halt autoimmunity in type 1 diabetes mellitus

(2012) A. E. Barcala Tabarrozzi et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity

(2012) Robin R. Knight et al.   DIABETES

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs  -Cell Function

(2012) S. A. Long et al.   DIABETES

Circulating Preproinsulin Signal Peptide-Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill  -Cells

(2012) D. Kronenberg et al.   DIABETES

Fall in C-Peptide During First 2 Years From Diagnosis: Evidence of at Least Two Distinct Phases From Composite Type 1 Diabetes TrialNet Data

(2012) C. J. Greenbaum et al.   DIABETES

Diabetic Ketoacidosis at Diagnosis Influences Complete Remission After Treatment With Hematopoietic Stem Cell Transplantation in Adolescents With Type 1 Diabetes

(2012) W. Gu et al.   DIABETES CARE

Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes

(2012) Martha Campbell-Thompson et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial

(2012) K. C. Herold et al.   DIABETOLOGIA

Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice

(2012) Tatiana Takiishi et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GAD65 Antigen Therapy in Recently Diagnosed Type 1 Diabetes Mellitus

(2012) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved Preservation of Residual Beta Cell Function by Atorvastatin in Patients with Recent Onset Type 1 Diabetes and High CRP Levels (DIATOR Trial)

(2012) Alexander Strom et al.   PLoS One

Proof-of-Concept, Randomized, Controlled Clinical Trial of Bacillus-Calmette-Guerin for Treatment of Long-Term Type 1 Diabetes

(2012) Denise L. Faustman et al.   PLoS One

Anti-thymoglobulin (ATG) treatment does not reverse type 1 diabetes in the acute virally induced rat insulin promoter-lymphocytic choriomeningitis virus (RIP-LCMV) model

(2011) D. Bresson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Incidental CD8 T cell reactivity against caspase-cleaved apoptotic self-antigens from ubiquitously expressed proteins in islets from prediabetic human leucocyte antigen-A2 transgenic non-obese diabetic mice

(2011) K. T. Coppieters et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Detection of four diabetes specific autoantibodies in a single radioimmunoassay: an innovative high-throughput approach for autoimmune diabetes screening

(2011) C. Tiberti et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

‘Insulin autoantibody affinity measurement using a single concentration of unlabelled insulin competitor discriminates risk in relatives of patients with type 1 diabetes

(2011) R. M. Curnock et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Serum titres of anti-glutamic acid decarboxylase-65 and anti-IA-2 autoantibodies are associated with different immunoregulatory milieu in newly diagnosed type 1 diabetes patients

(2011) M. Andrade Lima Gabbay et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Viruses and type 1 diabetes: ignorance acquires a better vocabulary

(2011) E. A. M. Gale   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunology in the clinic review series; focus on type 1 diabetes and viruses: the enterovirus link to type 1 diabetes: critical review of human studies

(2011) L. C. Stene et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunology in the clinic review series; focus on type 1 diabetes and viruses: how viral infections modulate beta cell function

(2011) F. A. Grieco et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma

(2011) K. T. Coppieters et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunology in the clinic review series; focus on type 1 diabetes and viruses: role of antibodies enhancing the infection with Coxsackievirus-B in the pathogenesis of type 1 diabetes

(2011) D. Hober et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunology in the clinic review series; focus on type 1 diabetes and viruses: the innate immune response to enteroviruses and its possible role in regulating type 1 diabetes

(2011) K. Lind et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunology in the clinic review series; focus on type 1 diabetes and viruses: enterovirus, thymus and type 1 diabetes pathogenesis

(2011) H. Jaïdane et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade: Evidence of Improved Immune Regulation

(2011) V. Ablamunits et al.   DIABETES

C-Peptide Response and HLA Genotypes in Subjects With Recent-Onset Type 1 Diabetes After Immunotherapy With DiaPep277

(2011) Raffaella Buzzetti et al.   DIABETES

Evidence That Nasal Insulin Induces Immune Tolerance to Insulin in Adults With Autoimmune Diabetes

(2011) S. Fourlanos et al.   DIABETES

Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide

(2011) M. J. Haller et al.   DIABETES CARE

Phase I (Safety) Study of Autologous Tolerogenic Dendritic Cells in Type 1 Diabetic Patients

(2011) N. Giannoukakis et al.   DIABETES CARE

Primary Dietary Intervention Study to Reduce the Risk of Islet Autoimmunity in Children at Increased Risk for Type 1 Diabetes: The BABYDIET study

(2011) S. Hummel et al.   DIABETES CARE

Effect of rituximab on human in vivo antibody immune responses

(2011) Mark D. Pescovitz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial

(2011) Diane K Wherrett et al.   LANCET

Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial

(2011) Nicole Sherry et al.   LANCET

Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial

(2011) Tihamer Orban et al.   LANCET

Preliminary studies related to anti-interleukin-1β therapy in children with newly diagnosed type 1 diabetes

(2011) Kathryn M. Sumpter et al.   PEDIATRIC DIABETES

Erythrocyte membrane omega-3 fatty acid levels and omega-3 fatty acid intake are not associated with conversion to type 1 diabetes in children with islet autoimmunity: The Diabetes Autoimmunity Study in the Young (DAISY)

(2011) Melissa R Miller et al.   PEDIATRIC DIABETES

Residual Beta Cell Function in Newly Diagnosed Type 1 Diabetes after Treatment with Atorvastatin: The Randomized DIATOR Trial

(2011) Stephan Martin et al.   PLoS One

Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group

(2010) J. B. Matthews et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society

(2010) R. Mallone et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Antigen-Specific Immunotherapy for Type 1 Diabetes: Maximizing the Potential

(2010) M. Peakman et al.   DIABETES

Virtual Optimization of Nasal Insulin Therapy Predicts Immunization Frequency to Be Crucial for Diabetes Protection

(2010) G. Fousteri et al.   DIABETES

Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

(2010) T. I. M. Tree et al.   DIABETES

No Effect of the 1 ,25-Dihydroxyvitamin D3 on  -Cell Residual Function and Insulin Requirement in Adults With New-Onset Type 1 Diabetes

(2010) M. Walter et al.   DIABETES CARE

Failure to Preserve  -Cell Function With Mycophenolate Mofetil and Daclizumab Combined Therapy in Patients With New- Onset Type 1 Diabetes

(2010) P. A. Gottlieb et al.   DIABETES CARE

Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass

(2010) B. Keymeulen et al.   DIABETOLOGIA

Erythrocyte membrane fatty acid content in infants consuming formulas supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA): an observational study

(2010) Melissa R. Miller et al.   Maternal and Child Nutrition

Dietary Intervention in Infancy and Later Signs of Beta-Cell Autoimmunity

(2010) Mikael Knip et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differences in Baseline Lymphocyte Counts and Autoreactivity Are Associated With Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients

(2009) R. Hilbrands et al.   DIABETES

Effect of Ingested Interferon-  on  -Cell Function in Children With New-Onset Type 1 Diabetes

(2009) K. I. Rother et al.   DIABETES CARE

Autologous Umbilical Cord Blood Transfusion in Very Young Children With Type 1 Diabetes

(2009) M. J. Haller et al.   DIABETES CARE

Etanercept Treatment in Children With New-Onset Type 1 Diabetes: Pilot randomized, placebo-controlled, double-blind study

(2009) L. Mastrandrea et al.   DIABETES CARE

Effect of combined oral proteases and flavonoid treatment in subjects at risk of Type 1 diabetes

(2009) K. Kempf et al.   DIABETIC MEDICINE

C-Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus

(2009) Carlos E. B. Couri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy

(2009) Tihamer Orban et al.   JOURNAL OF AUTOIMMUNITY

Genetic-induced Variations in the GAD65 T-cell Repertoire Governs Efficacy of Anti-CD3/GAD65 Combination Therapy in New-onset Type 1 Diabetes

(2009) Damien Bresson et al.   MOLECULAR THERAPY

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

(2009) Mark D. Pescovitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study

(2008) S. L. Thrower et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization

(2008) Peter Achenbach et al.   Current Diabetes Reports

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

(2008) Kirsti Näntö-Salonen et al.   LANCET

GAD Treatment and Insulin Secretion in Recent-Onset Type 1 Diabetes

(2008) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell Transplantation

(2008) Volkert A. L. Huurman et al.   PLoS One