Immunological pathways to β-cell damage in Type 1 diabetes

Antigen Targets of Type 1 Diabetes Autoimmunity

(2013) B. O. Roep et al.   Cold Spring Harbor Perspectives in Medicine

Immune responses against islet allografts during tapering of immunosuppression - a pilot study in 5 subjects

(2012) V. A. L. Huurman et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity

(2012) J. R. F. Abreu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Differential processing of self-antigens by subsets of thymic stromal cells

(2012) Sylvie Guerder et al.   CURRENT OPINION IN IMMUNOLOGY

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs  -Cell Function

(2012) S. A. Long et al.   DIABETES

Circulating Preproinsulin Signal Peptide-Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill  -Cells

(2012) D. Kronenberg et al.   DIABETES

Administration of CD4+CD25highCD127- Regulatory T Cells Preserves  -Cell Function in Type 1 Diabetes in Children

(2012) N. Marek-Trzonkowska et al.   DIABETES CARE

The multiple origins of Type 1 diabetes

(2012) A. Pugliese   DIABETIC MEDICINE

The environment and the origins of islet autoimmunity and Type 1 diabetes

(2012) S. Eringsmark Regnéll et al.   DIABETIC MEDICINE

Primary and secondary prevention of Type 1 diabetes

(2012) J. S. Skyler   DIABETIC MEDICINE

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional Specialization of Islet Dendritic Cell Subsets

(2012) N. Yin et al.   JOURNAL OF IMMUNOLOGY

Type 1 Diabetes-Associated IL2RA Variation Lowers IL-2 Signaling and Contributes to Diminished CD4+CD25+ Regulatory T Cell Function

(2012) G. Garg et al.   JOURNAL OF IMMUNOLOGY

Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes

(2012) Anna M Bulek et al.   NATURE IMMUNOLOGY

Low-Dose Interleukin-2 and HCV-Induced Vasculitis

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Incidental CD8 T cell reactivity against caspase-cleaved apoptotic self-antigens from ubiquitously expressed proteins in islets from prediabetic human leucocyte antigen-A2 transgenic non-obese diabetic mice

(2011) K. T. Coppieters et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Detection of four diabetes specific autoantibodies in a single radioimmunoassay: an innovative high-throughput approach for autoimmune diabetes screening

(2011) C. Tiberti et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunology in the Clinic Review Series; focus on metabolic diseases: development of islet autoimmune disease in type 2 diabetes patients: potential sequelae of chronic inflammation

(2011) B. Brooks-Worrell et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Viruses and type 1 diabetes: ignorance acquires a better vocabulary

(2011) E. A. M. Gale   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunology in the clinic review series; focus on type 1 diabetes and viruses: the enterovirus link to type 1 diabetes: critical review of human studies

(2011) L. C. Stene et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunology in the clinic review series; focus on type 1 diabetes and viruses: how viral infections modulate beta cell function

(2011) F. A. Grieco et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma

(2011) K. T. Coppieters et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunology in the clinic review series; focus on type 1 diabetes and viruses: role of antibodies enhancing the infection with Coxsackievirus-B in the pathogenesis of type 1 diabetes

(2011) D. Hober et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunology in the clinic review series; focus on type 1 diabetes and viruses: the innate immune response to enteroviruses and its possible role in regulating type 1 diabetes

(2011) K. Lind et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunology in the clinic review series; focus on type 1 diabetes and viruses: enterovirus, thymus and type 1 diabetes pathogenesis

(2011) H. Jaïdane et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated  -Cell Death

(2011) S. Arif et al.   DIABETES

Rituximab Selectively Suppresses Specific Islet Antibodies

(2011) L. Yu et al.   DIABETES

A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides

(2011) Linda Wooldridge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clues to immune tolerance: the monogenic autoimmune syndromes

(2010) Michael Waterfield et al.   Annals of the New York Academy of Sciences

Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes

(2010) S. I. Mannering et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society

(2010) R. Mallone et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

How thymic antigen presenting cells sample the body's self-antigens

(2010) Jens Derbinski et al.   CURRENT OPINION IN IMMUNOLOGY

Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell-Associated Epitopes Using Combinatorial MHC Multimers

(2010) J. H. Velthuis et al.   DIABETES

Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

(2010) T. I. M. Tree et al.   DIABETES

Foxp3+ T Cells Induce Perforin-Dependent Dendritic Cell Death in Tumor-Draining Lymph Nodes

(2010) Alexandre Boissonnas et al.   IMMUNITY

IL-17 Immunity in Human Type 1 Diabetes

(2010) J. Honkanen et al.   JOURNAL OF IMMUNOLOGY

Blockade of interleukin 1 in type 1 diabetes mellitus

(2010) Thomas Mandrup-Poulsen et al.   Nature Reviews Endocrinology

The role of perforin and granzymes in diabetes

(2009) H E Thomas et al.   CELL DEATH AND DIFFERENTIATION

Gene expression profiles for the human pancreas and purified islets in Type 1 diabetes: new findings at clinical onset and in long-standing diabetes

(2009) R. Planas et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes

(2009) F. S. Wong et al.   DIABETES

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

(2009) Mark D. Pescovitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased resistance to CD4+CD25hiregulatory T cell-mediated suppression in patients with type 1 diabetes

(2008) J. M. Lawson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY