Chirality in metal-based anticancer agents

Structure–activity relationships for ruthenium and osmium anticancer agents – towards clinical development

(2018) Samuel M. Meier-Menches et al.   CHEMICAL SOCIETY REVIEWS

Anticancer metal-N-heterocyclic carbene complexes of gold, platinum and palladium

(2018) Taotao Zou et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

New Class of Half-Sandwich Ruthenium(II) Arene Complexes Bearing the Water-Soluble CAP Ligand as an in Vitro Anticancer Agent

(2017) Antonella Guerriero et al.   INORGANIC CHEMISTRY

Organelle-targeting metal complexes: From molecular design to bio-applications

(2017) Kangqiang Qiu et al.   COORDINATION CHEMISTRY REVIEWS

An Amphiphilic Ruthenium Polymetallodrug for Combined Photodynamic Therapy and Photochemotherapy In Vivo

(2016) Wen Sun et al.   ADVANCED MATERIALS

Metal complexes for the detection of disease-related protein biomarkers

(2016) Dik-Lung Ma et al.   COORDINATION CHEMISTRY REVIEWS

Topoisomerase IIα poisoning and DNA double-strand breaking by chiral ruthenium(ii) complexes containing 2-furanyl-imidazo[4,5-f][1,10]phenanthroline derivatives

(2016) Chen Qian et al.   DALTON TRANSACTIONS

X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism

(2016) Aleksandar Bijelic et al.   JOURNAL OF MEDICINAL CHEMISTRY

Delivering the cell-impermeable DNA ‘light-switching’ Ru(ii) complexes preferentially into live-cell nucleus via an unprecedented ion-pairing method

(2016) Ben-Zhan Zhu et al.   Chemical Science

Effect of chirality in platinum drugs

(2015) Fabio Arnesano et al.   COORDINATION CHEMISTRY REVIEWS

Probing Chiral Recognition of Enzyme Active Sites with Octahedral Iridium(III) Propeller Complexes

(2015) Peter Göbel et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Highly selective anti-cancer properties of ester functionalized enantiopure dinuclear gold(I)-diphosphine

(2015) Bin-Bin Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Correlation between the Stereochemistry and Bioactivity in Octahedral Rhodium Prolinato Complexes

(2015) Rajathees Rajaratnam et al.   INORGANIC CHEMISTRY

NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

(2014) Robert Trondl et al.   Chemical Science

Mirror-Image Organometallic Osmium Arene Iminopyridine Halido Complexes Exhibit Similar Potent Anticancer Activity

(2013) Ying Fu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis, Characterisation and In Vitro Anticancer Activity of Hexanuclear Thiolato-Bridged Arene Ruthenium Metalla-Prisms

(2013) Mona A. Furrer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent advances in supramolecular and biological aspects of arene ruthenium(II) complexes

(2013) Ashish Kumar Singh et al.   COORDINATION CHEMISTRY REVIEWS

Human cancerous and healthy cell cytotoxicity studies of a chiral μ-dicarbene–digold(i) metallamacrocycle

(2013) Amrita B. Mullick et al.   DALTON TRANSACTIONS

Thioether-based anchimeric assistance for asymmetric coordination chemistry with ruthenium(ii) and osmium(ii)

(2013) Liang-An Chen et al.   DALTON TRANSACTIONS

Chiral ruthenium(ii) complexes with phenolic hydroxyl groups as dual poisons of topoisomerases I and IIα

(2013) Pingyu Zhang et al.   DALTON TRANSACTIONS

Picoplatin pharmacokinetics and chemotherapy of non-small cell lung cancer

(2013) Gerhard Hamilton et al.   Expert Opinion on Drug Metabolism & Toxicology

Dual topoisomerase I and II poisoning by chiral Ru(II) complexes containing 2-thiophenylimidazo[4,5-f][1,10]phenanthroline derivatives

(2013) Yu-Chuan Wang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Ferrocene–Biotin Conjugates Targeting Cancer Cells: Synthesis, Interaction with Avidin, Cytotoxic Properties and the Crystal Structure of the Complex of Avidin with a Biotin–Linker–Ferrocene Conjugate

(2013) Damian Plażuk et al.   ORGANOMETALLICS

In vitro and in vivo investigation of dexibuprofen derivatives for CNS delivery

(2012) Xuan Zhang et al.   ACTA PHARMACOLOGICA SINICA

The Art of Filling Protein Pockets Efficiently with Octahedral Metal Complexes

(2012) Sebastian Blanck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sixty Years Young: The Diverse Biological Activities of Metal Polypyridyl Complexes Pioneered by Francis P. Dwyer

(2012) Nathan L. Kilah et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

DNA Sequence and Ancillary Ligand Modulate the Biexponential Emission Decay of Intercalated [Ru(L)2dppz]2+Enantiomers

(2012) Andrew W. McKinley et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ruthenium(ii) arene PTA (RAPTA) complexes: impact of enantiomerically pure chiral ligands

(2012) Kelly J. Kilpin et al.   DALTON TRANSACTIONS

Lifetime Heterogeneity of DNA-Bound dppz Complexes Originates from Distinct Intercalation Geometries Determined by Complex–Complex Interactions

(2012) Johanna Andersson et al.   INORGANIC CHEMISTRY

Cyclometalated phenylquinoline rhodium complexes as protein kinase inhibitors

(2012) Stefan Mollin et al.   INORGANICA CHIMICA ACTA

Metallocenes as target specific drugs for cancer treatment

(2012) Enrique Meléndez   INORGANICA CHIMICA ACTA

Encapsulation of inorganic and organic guest molecules into an organometallic hexacationic arene osmium metalla-prism: Synthesis, characterisation and anticancer activity

(2012) Nicolas P.E. Barry et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

The contrasting chemical reactivity of potent isoelectronic iminopyridine and azopyridine osmium(ii) arene anticancer complexes

(2012) Ying Fu et al.   Chemical Science

Cover Picture: A Diagonal Approach to Chemical Recycling of Carbon Dioxide: Organocatalytic Transformation for the Reductive Functionalization of CO2 (Angew. Chem. Int. Ed. 1/2012)

(2011) Christophe Das Neves Gomes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Miscellaneous applications of ferrocene-based peptides/amides

(2011) Bhajan Lal et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Double Targeting of Tumours with Pyrenyl-Modified Dendrimers Encapsulated in an Arene-Ruthenium Metallaprism

(2011) Anaïs Pitto-Barry et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ruthenium(II) Complex Enantiomers as Cellular Probes for Diastereomeric Interactions in Confocal and Fluorescence Lifetime Imaging Microscopy

(2011) Frida R. Svensson et al.   Journal of Physical Chemistry Letters

Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors

(2011) Li Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thalidomide: The Tragedy of Birth Defects and the Effective Treatment of Disease

(2011) James H. Kim et al.   TOXICOLOGICAL SCIENCES

Beyond catalysis: N-heterocyclic carbene complexes as components for medicinal, luminescent, and functional materials applications

(2010) Laszlo Mercs et al.   CHEMICAL SOCIETY REVIEWS

Molecular architecture of redox-active half-sandwich Ru(ii) cyclic assemblies. Interactions with biomolecules and anticancer activity

(2010) Fátima Linares et al.   CRYSTENGCOMM

A new series of titanocene dichloride derivatives bearing chiral alkylammonium groups; assessment of their cytotoxic properties

(2010) Gregory D. Potter et al.   INORGANICA CHIMICA ACTA

Iron containing anti-tumoral agents: unexpected apoptosis-inducing activity of a ferrocene amino acid derivative

(2010) Benjamin Kater et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Organometallic Anticancer Compounds

(2010) Gilles Gasser et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enhanced Cellular Uptake and Cytotoxicity Studies of Organometallic Bioconjugates of the NLS Peptide in Hep G2 Cells

(2009) Fozia Noor et al.   CHEMBIOCHEM

The Medicinal Applications of Imidazolium Carbene−Metal Complexes

(2009) Khadijah M. Hindi et al.   CHEMICAL REVIEWS

Evidence for Drug Release from a Metalla-Cage Delivery Vector Following Cellular Internalisation

(2009) Olivier Zava et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Rational Design of Anticancer Platinum Complexes: The Importance of the Structure-Activity Relationship

(2009) Angel Montana et al.   CURRENT MEDICINAL CHEMISTRY

Tetranuclear Coordination Assemblies Based on Half-Sandwich Ruthenium(II) Complexes: Noncovalent Binding to DNA and Cytotoxicity

(2009) Fátima Linares et al.   INORGANIC CHEMISTRY

Mechanistic Insight into the Inhibition of Matrix Metalloproteinases by Platinum Substrates†

(2009) Fabio Arnesano et al.   JOURNAL OF MEDICINAL CHEMISTRY

The “Complex-in-a-Complex” Cations [(acac)2M⊂Ru6(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+: A Trojan Horse for Cancer Cells

(2008) Bruno Therrien et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Functionalised η6-arene ruthenium complexes

(2008) Bruno Therrien   COORDINATION CHEMISTRY REVIEWS

Organometallic complexes that interconvert between trimeric and monomeric structures as a function of pH and their effect on human cancer and fibroblast cells

(2008) Wee Han Ang et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

The replacement of a phenol group by an aniline or acetanilide group enhances the cytotoxicity of 2-ferrocenyl-1,1-diphenyl-but-l-ene compounds against breast cancer cells

(2008) Pascal Pigeon et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes

(2008) Jasna Maksimoska et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted Single-Wall Carbon Nanotube-Mediated Pt(IV) Prodrug Delivery Using Folate as a Homing Device

(2008) Shanta Dhar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles

(2008) S. Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA