Journal
INORGANICA CHIMICA ACTA
Volume 364, Issue 1, Pages 16-22Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2010.05.020
Keywords
Anti-cancer drugs; Titanocene dichloride; Metallocenes
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Funding
- Government of Ontario
- Natural Sciences and Engineering Research Council
- Canadian Institutes of Health Research [MOP-10519, STP-53913]
- Canada Research Chair Program
- Canadian Foundation for Innovation
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A series of new, water soluble titanocene dichloride derivatives containing chiral alkylammonium groups have been synthesized and characterized and their cytotoxicities against the human lung cancer cell lines A549, H209 and H209/CP have been assessed. The potencies of the compounds vary greatly, with primary ammonium salts being particularly ineffective. However, mono-and dicationic derivatives containing chiral ephedrine-type functional groups are very effective, in particular the dicationic species. (C) 2010 Published by Elsevier B.V.
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