Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology
Authors
Keywords
-
Journal
CLINICAL SCIENCE
Volume 132, Issue 8, Pages 851-868
Publisher
Portland Press Ltd.
Online
2018-04-30
DOI
10.1042/cs20171620
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cerebral Hemodynamics and Vascular Risk Factors: Setting the Stage for Alzheimer's Disease
- (2018) Jack C. de la Torre JOURNAL OF ALZHEIMERS DISEASE
- Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration
- (2017) Cátia F. Lourenço et al. FREE RADICAL BIOLOGY AND MEDICINE
- The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)
- (2017) Nathalie Percie du Sert et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells
- (2017) Scott G. Canfield et al. JOURNAL OF NEUROCHEMISTRY
- Opportunities and challenges in phenotypic drug discovery: an industry perspective
- (2017) John G. Moffat et al. NATURE REVIEWS DRUG DISCOVERY
- White matter damage and glymphatic dysfunction in a model of vascular dementia in rats with no prior vascular pathologies
- (2017) Poornima Venkat et al. NEUROBIOLOGY OF AGING
- Nonlinear temporal dynamics of cerebral small vessel disease
- (2017) Esther M.C. van Leijsen et al. NEUROLOGY
- White matter hyperintensity reduction and outcomes after minor stroke
- (2017) Joanna M. Wardlaw et al. NEUROLOGY
- Early life risk factors for cerebrovascular disease
- (2017) Ellen V. Backhouse et al. NEUROLOGY
- Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1
- (2017) Keisuke Yanagida et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neuroimaging Biomarkers Predict Brain Structural Connectivity Change in a Mouse Model of Vascular Cognitive Impairment
- (2017) Philipp Boehm-Sturm et al. STROKE
- Sample size considerations for trials using cerebral white matter hyperintensity progression as an intermediate outcome at 1 year after mild stroke: results of a prospective cohort study
- (2017) Francesca M. Chappell et al. Trials
- Role of Gasotransmitters in Oxidative Stresses, Neuroinflammation, and Neuronal Repair
- (2017) Ulfuara Shefa et al. Biomed Research International
- Vascular basement membranes as pathways for the passage of fluid into and out of the brain
- (2016) Alan W. J. Morris et al. ACTA NEUROPATHOLOGICA
- Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s disease
- (2016) Raj N. Kalaria ACTA NEUROPATHOLOGICA
- METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research
- (2016) Martin Dichgans et al. Alzheimers & Dementia
- Disruption of a miR-29 binding site leading toCOL4A1upregulation causes pontine autosomal dominant microangiopathy with leukoencephalopathy
- (2016) Edgard Verdura et al. ANNALS OF NEUROLOGY
- Cause and prevention of demyelination in a model multiple sclerosis lesion
- (2016) Roshni A. Desai et al. ANNALS OF NEUROLOGY
- Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice
- (2016) Carmen Capone et al. ANNALS OF NEUROLOGY
- Carotid disease at age 73 and cognitive change from age 70 to 76 years: A longitudinal cohort study
- (2016) Joanna M Wardlaw et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Impairment of the glymphatic system after diabetes
- (2016) Quan Jiang et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Cerebral blood flow in small vessel disease: A systematic review and meta-analysis
- (2016) Yulu Shi et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Structural and functional brain alterations in a murine model of Angiotensin II-induced hypertension
- (2016) Anja Meissner et al. JOURNAL OF NEUROCHEMISTRY
- Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study
- (2016) Zoe Arvanitakis et al. LANCET NEUROLOGY
- Induced pluripotent stem cell technology: a decade of progress
- (2016) Yanhong Shi et al. NATURE REVIEWS DRUG DISCOVERY
- Cathepsin A–related arteriopathy with strokes and leukoencephalopathy (CARASAL)
- (2016) Marianna Bugiani et al. NEUROLOGY
- Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics
- (2016) Carmen Capone et al. eLife
- Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans
- (2016) Yorito Hattori et al. Journal of the American Heart Association
- HeterozygousHTRA1mutations are associated with autosomal dominant cerebral small vessel disease
- (2015) Edgard Verdura et al. BRAIN
- Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations
- (2015) Kenzo Koizumi et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Progression of MRI markers in cerebral small vessel disease: Sample size considerations for clinical trials
- (2015) Philip Benjamin et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Gliovascular Disruption and Cognitive Deficits in a Mouse Model with Features of Small Vessel Disease
- (2015) Philip R Holland et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Ultra-fast magnetic resonance encephalography of physiological brain activity – Glymphatic pulsation mechanisms?
- (2015) Vesa Kiviniemi et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Perturbations of the cerebrovascular matrisome: A convergent mechanism in small vessel disease of the brain?
- (2015) Anne Joutel et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Genetic factors in cerebral small vessel disease and their impact on stroke and dementia
- (2015) Christof Haffner et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke
- (2015) Samaneh Maysami et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Hypoxia-Induced Neuroinflammatory White-Matter Injury Reduced by Minocycline in SHR/SP
- (2015) Fakhreya Y Jalal et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
- (2015) Aleksanteri Aspelund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Effect of Body Posture on Brain Glymphatic Transport
- (2015) H. Lee et al. JOURNAL OF NEUROSCIENCE
- Structural and functional features of central nervous system lymphatic vessels
- (2015) Antoine Louveau et al. NATURE
- The Glymphatic System: A Beginner’s Guide
- (2015) Nadia Aalling Jessen et al. NEUROCHEMICAL RESEARCH
- Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease
- (2015) K. Rannikmae et al. NEUROLOGY
- Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia
- (2015) Gemma Llovera et al. Science Translational Medicine
- Genes From a Translational Analysis Support a Multifactorial Nature of White Matter Hyperintensities
- (2015) Lorna M. Lopez et al. STROKE
- Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene
- (2015) J. Nithianantharajah et al. Scientific Reports
- Nox4 Is a Major Source of Superoxide Production in Human Brain Pericytes
- (2015) Junya Kuroda et al. JOURNAL OF VASCULAR RESEARCH
- Impairment of paravascular clearance pathways in the aging brain
- (2014) Benjamin T. Kress et al. ANNALS OF NEUROLOGY
- Oxidative stress, redox signalling and endothelial dysfunction in ageing-related neurodegenerative diseases: a role of NADPH oxidase 2
- (2014) Sarah Cahill-Smith et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Molecular Links Between Endothelial Dysfunction and Neurodegeneration in Alzheimer's Disease
- (2014) Epameinondas Lyros et al. Current Alzheimer Research
- Hypertension Fails to Disrupt White Matter Integrity in Young Or Aged Fisher (F44) Cyp1a1Ren2 Transgenic Rats
- (2014) Philip R Holland et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation
- (2014) Sophocles Chrissobolis et al. JOURNAL OF HYPERTENSION
- Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury
- (2014) Jeffrey J. Iliff et al. JOURNAL OF NEUROSCIENCE
- Vascular risk factors, large-artery atheroma, and brain white matter hyperintensities
- (2014) J. M. Wardlaw et al. NEUROLOGY
- Structural network efficiency is associated with cognitive impairment in small-vessel disease
- (2014) A. J. Lawrence et al. NEUROLOGY
- Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke
- (2014) Emma L. Bailey et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Tumor necrosis factor-α-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation
- (2014) Junichi Matsumoto et al. NEUROSCIENCE LETTERS
- Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling
- (2014) Nathalie Beaufort et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Systematic Review and Meta-Analysis of Interventions Tested in Animal Models of Lacunar Stroke
- (2014) Hugo Pedder et al. STROKE
- The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction
- (2014) L. Park et al. Nature Communications
- Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase
- (2013) Peter Toth et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Abnormal recruitment of extracellular matrix proteins by excess Notch3ECD: a new pathomechanism in CADASIL
- (2013) Marie Monet-Leprêtre et al. BRAIN
- Endothelial TRPV4 channels mediate dilation of cerebral arteries: impairment and recovery in cerebrovascular pathologies related to Alzheimer's disease
- (2013) Luqing Zhang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Touching on translation
- (2013) John Talpos et al. CELL AND TISSUE RESEARCH
- Endothelial nitric oxide: protector of a healthy mind
- (2013) Z. S. Katusic et al. EUROPEAN HEART JOURNAL
- An MRI-Histological Study of White Matter in Stroke-Free SHRSP
- (2013) John F Brittain et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device
- (2013) Andries D. van der Meer et al. LAB ON A CHIP
- Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging
- (2013) Joanna M Wardlaw et al. LANCET NEUROLOGY
- Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
- (2013) Joanna M Wardlaw et al. LANCET NEUROLOGY
- The touchscreen operant platform for assessing executive function in rats and mice
- (2013) Adam C Mar et al. Nature Protocols
- The touchscreen operant platform for testing working memory and pattern separation in rats and mice
- (2013) Charlotte A Oomen et al. Nature Protocols
- The touchscreen operant platform for testing learning and memory in rats and mice
- (2013) Alexa E Horner et al. Nature Protocols
- Cognitive components in mice and humans: Combining genetics and touchscreens for medical translation
- (2013) Jess Nithianantharajah et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Pulse wave velocity is associated with -amyloid deposition in the brains of very elderly adults
- (2013) T. M. Hughes et al. NEUROLOGY
- The Pathobiology of Vascular Dementia
- (2013) Costantino Iadecola NEURON
- Garbage Truck of the Brain
- (2013) M. Nedergaard SCIENCE
- Sleep Drives Metabolite Clearance from the Adult Brain
- (2013) L. Xie et al. SCIENCE
- Systematic review of the body of evidence for the use of biomarkers in the diagnosis of dementia
- (2012) Anna H. Noel-Storr et al. Alzheimers & Dementia
- COL4A1 and COL4A2 mutations and disease: insights into pathogenic mechanisms and potential therapeutic targets
- (2012) D. S. Kuo et al. HUMAN MOLECULAR GENETICS
- Role of Nox isoforms in angiotensin II-induced oxidative stress and endothelial dysfunction in brain
- (2012) Sophocles Chrissobolis et al. JOURNAL OF APPLIED PHYSIOLOGY
- Generation of human vascular smooth muscle subtypes provides insight into embryological origin–dependent disease susceptibility
- (2012) Christine Cheung et al. NATURE BIOTECHNOLOGY
- Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells
- (2012) Ethan S Lippmann et al. NATURE BIOTECHNOLOGY
- A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid
- (2012) J. J. Iliff et al. Science Translational Medicine
- Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy
- (2011) Cheryl A. Hawkes et al. ACTA NEUROPATHOLOGICA
- Protecting against vascular disease in brain
- (2011) Frank M. Faraci AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Antioxidant protection: A promising therapeutic intervention in neurodegenerative disease
- (2011) Nilanjan Ghosh et al. FREE RADICAL RESEARCH
- Is the Spontaneously Hypertensive Stroke Prone Rat a Pertinent Model of Sub Cortical Ischemic Stroke? A Systematic Review
- (2011) Emma L. Bailey et al. International Journal of Stroke
- Impaired Attention in the 3xTgAD Mouse Model of Alzheimer's Disease: Rescue by Donepezil (Aricept)
- (2011) C. Romberg et al. JOURNAL OF NEUROSCIENCE
- Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats
- (2011) E. L. Bailey et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions
- (2011) R. O. Hynes et al. Cold Spring Harbor Perspectives in Biology
- Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination
- (2010) Rakhi Sharma et al. ACTA NEUROPATHOLOGICA
- The cerebrovascular dysfunction induced by slow pressor doses of angiotensin II precedes the development of hypertension
- (2010) Carmen Capone et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Experimental models of vascular dementia and vascular cognitive impairment: a systematic review
- (2010) Nadim S. Jiwa et al. JOURNAL OF NEUROCHEMISTRY
- Selective white matter pathology induces a specific impairment in spatial working memory
- (2010) Robin Coltman et al. NEUROBIOLOGY OF AGING
- Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging
- (2010) Robert D. Bell et al. NEURON
- Assessing cognitive function in clinical trials of schizophrenia
- (2010) Jennifer H. Barnett et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Counting Cavitating Lacunes Underestimates the Burden of Lacunar Infarction
- (2010) Gillian M. Potter et al. STROKE
- Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research
- (2010) Carol Kilkenny et al. PLOS BIOLOGY
- Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-α in cerebral vascular endothelial cells
- (2009) Shyamali Basuroy et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Overexpression of Dimethylarginine Dimethylaminohydrolase Protects Against Cerebral Vascular Effects of Hyperhomocysteinemia
- (2009) Roman N. Rodionov et al. CIRCULATION RESEARCH
- Emulating Multicentre Clinical Stroke Trials: A New Paradigm for Studying Novel Interventions in Experimental Models of Stroke
- (2009) P. M. W. Bath et al. International Journal of Stroke
- Association of HTRA1 Mutations and Familial Ischemic Cerebral Small-Vessel Disease
- (2009) Kenju Hara et al. NEW ENGLAND JOURNAL OF MEDICINE
- Potential Animal Models of Lacunar Stroke
- (2009) Emma L. Bailey et al. STROKE
- Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations
- (2009) Marc Fisher et al. STROKE
- Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology
- (2008) R. O. Carare et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started