Protecting against vascular disease in brain

Activation of Peroxisome Proliferator-Activated Receptor   (PPAR ) Suppresses Rho GTPases in Human Brain Microvascular Endothelial Cells and Inhibits Adhesion and Transendothelial Migration of HIV-1 Infected Monocytes

(2014) S. H. Ramirez et al.   JOURNAL OF IMMUNOLOGY

Regulation of Endothelial Function by Mitochondrial Reactive Oxygen Species

(2011) Michael E. Widlansky et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Blood Pressure and Salt Homeostasis by Endothelin

(2011) Donald E. Kohan et al.   PHYSIOLOGICAL REVIEWS

International Stroke Conference Oral Presentations

(2011)   STROKE

The Nuclear Hormone Receptor PPARγas a Therapeutic Target in Major Diseases

(2011) Martina Victoria Schmidt et al.   TheScientificWorldJOURNAL

The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia

(2010) Costantino Iadecola   ACTA NEUROPATHOLOGICA

The cerebrovascular dysfunction induced by slow pressor doses of angiotensin II precedes the development of hypertension

(2010) Carmen Capone et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NADPH Oxidase 2 Mediates Intermittent Hypoxia-Induced Mitochondrial Complex I Inhibition: Relevance to Blood Pressure Changes in Rats

(2010) Shakil A. Khan et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation of NAD(P)H Oxidases by Thromboxane A 2 Receptor Uncouples Endothelial Nitric Oxide Synthase

(2010) Miao Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The nuclear factor- B-interleukin-6 signalling pathway mediating vascular inflammation

(2010) A. R. Brasier   CARDIOVASCULAR RESEARCH

PPARs: diverse regulators in energy metabolism and metabolic diseases

(2010) Yong-Xu Wang   CELL RESEARCH

RhoA/Rho-kinase and vascular diseases: what is the link?

(2010) Kenia Pedrosa Nunes et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endothelial Nitric Oxide Synthase Deficiency Causes Collateral Vessel Rarefaction and Impairs Activation of a Cell Cycle Gene Network During Arteriogenesis

(2010) Xuming Dai et al.   CIRCULATION RESEARCH

Endothelial Nitric Oxide Modulates Expression and Processing of Amyloid Precursor Protein

(2010) Susan A. Austin et al.   CIRCULATION RESEARCH

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5

(2010) Augusto C. Montezano et al.   CLINICAL SCIENCE

Endothelium-derived Vasoactive Factors and Hypertension: Possible Roles in Pathogenesis and as Treatment Targets

(2010) Michel Félétou et al.   CURRENT HYPERTENSION REPORTS

Angiotensin II revisited: new roles in inflammation, immunology and aging

(2010) Ariela Benigni et al.   EMBO Molecular Medicine

Is oxidative stress a therapeutic target in cardiovascular disease?

(2010) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

Sex Differences in Protection Against Angiotensin II–Induced Endothelial Dysfunction by Manganese Superoxide Dismutase in the Cerebral Circulation

(2010) Sophocles Chrissobolis et al.   HYPERTENSION

Cyclooxygenase 1–Derived Prostaglandin E 2 and EP1 Receptors Are Required for the Cerebrovascular Dysfunction Induced by Angiotensin II

(2010) Carmen Capone et al.   HYPERTENSION

Erythropoietin Increases Expression and Function of Vascular Copper- and Zinc-Containing Superoxide Dismutase

(2010) Livius V. d'Uscio et al.   HYPERTENSION

Inflammation, Immunity, and Hypertension

(2010) David G. Harrison et al.   HYPERTENSION

Cerebral vascular adaptation to pregnancy and its role in the neurological complications of eclampsia

(2010) Marilyn J. Cipolla et al.   JOURNAL OF APPLIED PHYSIOLOGY

Does Peroxisome Proliferator-activated Receptor-γ (PPARγ) Protect from Hypertension Directly through Effects in the Vasculature?

(2010) Pimonrat Ketsawatsomkron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intact Memory in TGF-β1 Transgenic Mice Featuring Chronic Cerebrovascular Deficit: Recovery with Pioglitazone

(2010) Nektaria Nicolakakis et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Alterations in Nitric Oxide and Endothelin-1 Bioactivity Underlie Cerebrovascular Dysfunction in ApoE-Deficient Mice

(2010) Kazuo Yamashiro et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease

(2010) Anne Joutel et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparison of Endothelium-Related Responses to Nucleotides of Dog and Monkey Cerebral Arteries

(2010) Ayman Geddawy et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A redox switch in angiotensinogen modulates angiotensin release

(2010) Aiwu Zhou et al.   NATURE

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

The role of Rho protein signaling in hypertension

(2010) Gervaise Loirand et al.   Nature Reviews Cardiology

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Review: Molecular pathogenesis of blood-brain barrier breakdown in acute brain injury

(2010) S. Nag et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Angiotensin II induced cerebral microvascular inflammation and increased blood–brain barrier permeability via oxidative stress

(2010) M. Zhang et al.   NEUROSCIENCE

Human endothelial dysfunction: EDCFs

(2010) Agostino Virdis et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

(2010) S. H. Francis et al.   PHARMACOLOGICAL REVIEWS

Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications

(2010) Juan M. Saavedra et al.   PSYCHONEUROENDOCRINOLOGY

Augmented Superoxide Production By Nox2-Containing NADPH Oxidase Causes Cerebral Artery Dysfunction During Hypercholesterolemia

(2010) Alyson A. Miller et al.   STROKE

Receptor Activity-Modifying Protein-1 Augments Cerebrovascular Responses to Calcitonin Gene-Related Peptide and Inhibits Angiotensin II-Induced Vascular Dysfunction

(2010) Sophocles Chrissobolis et al.   STROKE

PPARγ Activation Prevents Hypertensive Remodeling of Cerebral Arteries and Improves Vascular Function in Female Rats

(2010) Marilyn J. Cipolla et al.   STROKE

Pumps, Aqueducts, and Drought Management

(2010) Randolph S. Marshall et al.   STROKE

When neurogenesis encounters aging and disease

(2010) Orly Lazarov et al.   TRENDS IN NEUROSCIENCES

PPARs in the Renal Regulation of Systemic Blood Pressure

(2010) Tamás Rőszer et al.   PPAR Research

Endothelial dysfunction and vascular disease

(2009) P. M. Vanhoutte et al.   Acta Physiologica

PPAR-γ agonist rosiglitazone reverses increased cerebral venous hydraulic conductivity during hypertension

(2009) Tim J. M. Roberts et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging

(2009) Mary L. Modrick et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ischemia-induced brain damage is enhanced in human renin and angiotensinogen double-transgenic mice

(2009) Shuzhen Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Cross-Talk Between Mitochondria and NADPH Oxidase: Effects of Mild Mitochondrial Dysfunction on Angiotensin II-Mediated Increase in Nox Isoform Expression and Activity in Vascular Smooth Muscle Cells

(2009) João Wosniak et al.   ANTIOXIDANTS & REDOX SIGNALING

Dominant-Negative Loss of PPARγ Function Enhances Smooth Muscle Cell Proliferation, Migration, and Vascular Remodeling

(2009) Dane Meredith et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bioinformatic Analysis of Gene Sets Regulated by Ligand-Activated and Dominant-Negative Peroxisome Proliferator–Activated Receptor γ in Mouse Aorta

(2009) Henry L. Keen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Rosiglitazone Reduces the Development and Rupture of Experimental Aortic Aneurysms

(2009) Alun Jones et al.   CIRCULATION

Ligand-Activated Peroxisome Proliferator–Activated Receptor-γ Protects Against Ischemic Cerebral Infarction and Neuronal Apoptosis by 14-3-3ε Upregulation

(2009) Jui-Sheng Wu et al.   CIRCULATION

Endothelium-Dependent Cerebral Artery Dilation Mediated by TRPA1 and Ca 2+ -Activated K + Channels

(2009) Scott Earley et al.   CIRCULATION RESEARCH

Overexpression of Dimethylarginine Dimethylaminohydrolase Protects Against Cerebral Vascular Effects of Hyperhomocysteinemia

(2009) Roman N. Rodionov et al.   CIRCULATION RESEARCH

Oxidative risk for atherothrombotic cardiovascular disease

(2009) Jane A. Leopold et al.   FREE RADICAL BIOLOGY AND MEDICINE

Estrous Cycle–Dependent Neurovascular Dysfunction Induced by Angiotensin II in the Mouse Neocortex

(2009) Carmen Capone et al.   HYPERTENSION

Protection of Angiotensin II–Induced Vascular Hypertrophy in Vascular Smooth Muscle–Targeted Receptor Activity-Modifying Protein 2 Transgenic Mice

(2009) Lihuan Liang et al.   HYPERTENSION

Endogenous Interleukin-10 Inhibits Angiotensin II–Induced Vascular Dysfunction

(2009) Sean P. Didion et al.   HYPERTENSION

Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated With Recovery of Neurovascular Coupling

(2009) Shuko Takeda et al.   HYPERTENSION

Endothelial and Vascular Muscle PPARγ in Arterial Pressure Regulation

(2009) Curt D. Sigmund   HYPERTENSION

Role of Hydrogen Peroxide and the Impact of Glutathione Peroxidase-1 in Regulation of Cerebral Vascular Tone

(2009) Mary L Modrick et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Angiotensin II Modulates BBB Permeability via Activation of the AT1 Receptor in Brain Endothelial Cells

(2009) Melissa A Fleegal-DeMotta et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase

(2009) Annemarieke E. Loot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoantibody against AT1 receptor from preeclamptic patients induces vasoconstriction through angiotensin receptor activation

(2009) Xiaoli Yang et al.   JOURNAL OF HYPERTENSION

Altered structure of small cerebral arteries in patients with essential hypertension

(2009) Damiano Rizzoni et al.   JOURNAL OF HYPERTENSION

An Oligovascular Niche: Cerebral Endothelial Cells Promote the Survival and Proliferation of Oligodendrocyte Precursor Cells

(2009) K. Arai et al.   JOURNAL OF NEUROSCIENCE

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Nitric oxide synthase–dependent responses of the basilar artery during acute infusion of nicotine

(2009) William G. Mayhan et al.   NICOTINE & TOBACCO RESEARCH

Cerebral Blood Flow Regulation by Nitric Oxide: Recent Advances

(2009) N. Toda et al.   PHARMACOLOGICAL REVIEWS

Gender Influences Cerebral Vascular Responses to Angiotensin II Through Nox2-Derived Reactive Oxygen Species

(2009) T. Michael De Silva et al.   STROKE

SK Ca and IK Ca Channels, Myogenic Tone, and Vasodilator Responses in Middle Cerebral Arteries and Parenchymal Arterioles

(2009) Marilyn J. Cipolla et al.   STROKE

Migraine headache is not associated with cerebral or meningeal vasodilatation—a 3T magnetic resonance angiography study

(2008) G. G. Schoonman et al.   BRAIN

Losartan improves impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type 1 diabetic rats

(2008) Denise M. Arrick et al.   BRAIN RESEARCH

Interference with PPARγ Function in Smooth Muscle Causes Vascular Dysfunction and Hypertension

(2008) Carmen M. Halabi et al.   Cell Metabolism

Hypertension and Cerebrovascular Dysfunction

(2008) Costantino Iadecola et al.   Cell Metabolism

Endothelium-Specific Interference With Peroxisome Proliferator Activated Receptor Gamma Causes Cerebral Vascular Dysfunction in Response to a High-Fat Diet

(2008) Andreas M. Beyer et al.   CIRCULATION RESEARCH

Bcr Kinase Activation by Angiotensin II Inhibits Peroxisome Proliferator-Activated Receptor γ Transcriptional Activity in Vascular Smooth Muscle Cells

(2008) Jeffrey D. Alexis et al.   CIRCULATION RESEARCH

New insights into the causes and therapy of cerebral vasospasm following subarachnoid hemorrhage

(2008) R. Webster Crowley et al.   DRUG DISCOVERY TODAY

Protective effects of angiotensin II Type 1 receptor blocker on cerebral circulation independent of blood pressure

(2008) Yasuhiro Kumai et al.   EXPERIMENTAL NEUROLOGY

Interference With PPARγ Signaling Causes Cerebral Vascular Dysfunction, Hypertrophy, and Remodeling

(2008) Andreas M. Beyer et al.   HYPERTENSION

Glutathione Peroxidase-1 Plays a Major Role in Protecting Against Angiotensin II–Induced Vascular Dysfunction

(2008) Sophocles Chrissobolis et al.   HYPERTENSION

Effect of Telmisartan on Nitric Oxide–Asymmetrical Dimethylarginine System

(2008) Fortunato Scalera et al.   HYPERTENSION

Inflammation and endothelial dysfunction during aging: role of NF-κB

(2008) Anna Csiszar et al.   JOURNAL OF APPLIED PHYSIOLOGY

Blockade of AT1 receptor partially restores vasoreactivity, NOS expression, and superoxide levels in cerebral and carotid arteries of hindlimb unweighting rats

(2008) Ran Zhang et al.   JOURNAL OF APPLIED PHYSIOLOGY

AT1-receptor autoantibodies and uteroplacental RAS in pregnancy and pre-eclampsia

(2008) Florian Herse et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Complete Rescue of Cerebrovascular Function in Aged Alzheimer's Disease Transgenic Mice by Antioxidants and Pioglitazone, a Peroxisome Proliferator-Activated Receptor   Agonist

(2008) N. Nicolakakis et al.   JOURNAL OF NEUROSCIENCE

Age-Related Alterations in Reactivity of Cerebral Arterioles: Role of Oxidative Stress

(2008) William G. Mayhan et al.   MICROCIRCULATION

Reactivity of Brain Parenchymal Arterioles after Ischemia and Reperfusion

(2008) Marilyn J. Cipolla et al.   MICROCIRCULATION

Translating molecular discoveries into new therapies for atherosclerosis

(2008) Daniel J. Rader et al.   NATURE

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

(2008) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebrovascular Angiotensin AT1 Receptor Regulation in Cerebral Ischemia

(2008) Lars Edvinsson   TRENDS IN CARDIOVASCULAR MEDICINE

The role of oxidative stress and NADPH oxidase in cerebrovascular disease

(2008) Sophocles Chrissobolis et al.   TRENDS IN MOLECULAR MEDICINE

Role of the renin–angiotensin system in vascular inflammation

(2008) Chiara Marchesi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Measurement of carotid intima–media thickness to assess progression and regression of atherosclerosis

(2008) Eric de Groot et al.   Nature clinical practice. Cardiovascular medicine

The neurovascular dysfunction induced by angiotensin II in the mouse neocortex is sexually dimorphic

(2007) H. Girouard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Overexpression of Dimethylarginine Dimethylaminohydrolase Inhibits Asymmetric Dimethylarginine–Induced Endothelial Dysfunction in the Cerebral Circulation

(2007) Hayan Dayoub et al.   STROKE