The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction

Early Adult to Midlife Cardiovascular Risk Factors and Cognitive Function

(2014) Kristine Yaffe et al.   CIRCULATION

Contribution of Alzheimer disease to mortality in the United States

(2014) B. D. James et al.   NEUROLOGY

Cerebral perfusion alterations and cerebral amyloid in autosomal dominant Alzheimer disease

(2014) E. McDade et al.   NEUROLOGY

A Critical Role for the Vascular Endothelium in Functional Neurovascular Coupling in the Brain

(2014) Brenda R. Chen et al.   Journal of the American Heart Association

Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment

(2013) Jie Liu et al.   Alzheimers & Dementia

COX-1-derived PGE2 and PGE2 type 1 receptors are vital for angiotensin II-induced formation of reactive oxygen species and Ca2+ influx in the subfornical organ

(2013) Gang Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Centre

(2013) Jon B. Toledo et al.   BRAIN

Cooperative Interaction of trp Melastatin Channel Transient Receptor Potential (TRPM2) With Its Splice Variant TRPM2 Short Variant Is Essential for Endothelial Cell Apoptosis

(2013) Claudie M. Hecquet et al.   CIRCULATION RESEARCH

Androgen and PARP-1 Regulation of TRPM2 Channels after Ischemic Injury

(2013) Takeru Shimizu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neurovascular decoupling is associated with severity of cerebral amyloid angiopathy

(2013) S. Peca et al.   NEUROLOGY

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

New Insights into the Dementia Epidemic

(2013) Eric B. Larson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Innate immunity receptor CD36 promotes cerebral amyloid angiopathy

(2013) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Functional magnetic resonance imaging detection of vascular reactivity in cerebral amyloid angiopathy

(2012) Andrew Dumas et al.   ANNALS OF NEUROLOGY

Cerebral amyloid angiopathy burden associated with leukoaraiosis: A positron emission tomography/magnetic resonance imaging study

(2012) M. Edip Gurol et al.   ANNALS OF NEUROLOGY

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyperactivation of PARP Triggers Nonhomologous End-Joining in Repair-Deficient Mouse Fibroblasts

(2012) Natalie R. Gassman et al.   PLoS One

Transient receptor potential channels as therapeutic targets

(2011) Magdalene M. Moran et al.   NATURE REVIEWS DRUG DISCOVERY

Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid- 

(2011) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos)

(2011) Y. Wang et al.   Science Signaling

Vascular Contributions to Cognitive Impairment and Dementia

(2011) Philip B. Gorelick et al.   STROKE

Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death

(2010) C. Blenn et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification of Direct and Indirect Effectors of the Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel

(2010) Balázs Tóth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiovascular Risk Factors and Incident Alzheimer Disease

(2009) Christianna Purnell et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Treatment of vascular risk factors is associated with slower decline in Alzheimer disease

(2009) Y. Deschaintre et al.   NEUROLOGY

Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease

(2008) Alex E. Roher et al.   Alzheimers & Dementia

Role of the Peroxynitrite-Poly(ADP-Ribose) Polymerase Pathway in Human Disease

(2008) Pal Pacher et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB)

(2008) K Togashi et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Poly(ADP-ribose) Polymerase PARP-1 Is Required for Oxidative Stress-induced TRPM2 Activation in Lymphocytes

(2008) Ben Buelow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

(2008) Shinichiro Yamamoto et al.   NATURE MEDICINE

Detection of changed regional cerebral blood flow in mild cognitive impairment and early Alzheimer's dementia by perfusion-weighted magnetic resonance imaging

(2008) Christian Luckhaus et al.   NEUROIMAGE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

(2008) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of TRPM2 Channel in Mediating H 2 O 2 -Induced Ca 2+ Entry and Endothelial Hyperpermeability

(2007) Claudie M. Hecquet et al.   CIRCULATION RESEARCH