Perturbations of the cerebrovascular matrisome: A convergent mechanism in small vessel disease of the brain?

Molecular and Genetic Analyses of Collagen Type IV Mutant Mouse Models of Spontaneous Intracerebral Hemorrhage Identify Mechanisms for Stroke PreventionCLINICAL PERSPECTIVE

(2015) Marion Jeanne et al.   CIRCULATION

Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease

(2015) Fabrice Dabertrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin β1 controls VE-cadherin localization and blood vessel stability

(2015) Hiroyuki Yamamoto et al.   Nature Communications

CADASIL and CARASIL

(2014) Saara Tikka et al.   BRAIN PATHOLOGY

The Proteome of Mouse Cerebral Arteries

(2014) AmanPreet Badhwar et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease

(2014) Curtis R. French et al.   JOURNAL OF CLINICAL INVESTIGATION

The Extracellular Matrix Protein Laminin  2 Regulates the Maturation and Function of the Blood-Brain Barrier

(2014) M. J. Menezes et al.   JOURNAL OF NEUROSCIENCE

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling

(2014) Nathalie Beaufort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features of Cerebral Autosomal Recessive Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

(2014) Hiroaki Nozaki et al.   STROKE

A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress

(2014) Namrata Chaudhari et al.   Frontiers in Cellular Neuroscience

Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity

(2014) Yao Yao et al.   Nature Communications

Early white matter changes in CADASIL: evidence of segmental intramyelinic oedema in a pre-clinical mouse model

(2014) Emmanuel Cognat et al.   Acta Neuropathologica Communications

Sequestration of latent TGF-β binding protein 1 into CADASIL-related Notch3-ECD deposits

(2014) Jessica Kast et al.   Acta Neuropathologica Communications

The effects of hypertension on the cerebral circulation

(2013) Paulo W. Pires et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

β1-Integrin Is Essential for Vasoregulation and Smooth Muscle Survival In Vivo

(2013) Kirsten A. Turlo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Abnormal recruitment of extracellular matrix proteins by excess Notch3ECD: a new pathomechanism in CADASIL

(2013) Marie Monet-Leprêtre et al.   BRAIN

Genetics of Thoracic Aortic Aneurysm

(2013) Elisabeth Gillis et al.   CIRCULATION RESEARCH

Transforming growth factor β family members in regulation of vascular function: In the light of vascular conditional knockouts

(2013) Lars Jakobsson et al.   EXPERIMENTAL CELL RESEARCH

Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke

(2013) Lydia S. Murray et al.   HUMAN MOLECULAR GENETICS

Allelic heterogeneity contributes to variability in ocular dysgenesis, myopathy and brain malformations caused by Col4a1 and Col4a2 mutations

(2013) Debbie S. Kuo et al.   HUMAN MOLECULAR GENETICS

Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke

(2013) Zu-Lin Chen et al.   JOURNAL OF CELL BIOLOGY

Serine Protease HTRA1 Antagonizes Transforming Growth Factor-β Signaling by Cleaving Its Receptors and Loss of HTRA1 In Vivo Enhances Bone Formation

(2013) Julie R. Graham et al.   PLoS One

Laminin isoforms in endothelial and perivascular basement membranes

(2013) Lema F. Yousif et al.   Cell Adhesion & Migration

Laminins in basement membrane assembly

(2013) Erhard Hohenester et al.   Cell Adhesion & Migration

Foxc1 is required by pericytes during fetal brain angiogenesis

(2013) J. A. Siegenthaler et al.   Biology Open

Phenotypic Spectrum ofCOL4A1Mutations: Porencephaly to Schizencephaly

(2012) Yuriko Yoneda et al.   ANNALS OF NEUROLOGY

Notch signalling in smooth muscle cells during development and disease

(2012) C. Fouillade et al.   CARDIOVASCULAR RESEARCH

Novel COL4A1 mutations cause cerebral small vessel disease by haploinsufficiency

(2012) R. Lemmens et al.   HUMAN MOLECULAR GENETICS

COL4A1 and COL4A2 mutations and disease: insights into pathogenic mechanisms and potential therapeutic targets

(2012) D. S. Kuo et al.   HUMAN MOLECULAR GENETICS

The Epidermal Basement Membrane Is a Composite of Separate Laminin- or Collagen IV-containing Networks Connected by Aggregated Perlecan, but Not by Nidogens

(2012) Daniel Timo Behrens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Towards definition of an ECM parts list: An advance on GO categories

(2012) Alexandra Naba et al.   MATRIX BIOLOGY

Inward remodeling of resistance arteries requires reactive oxygen species-dependent activation of matrix metalloproteinases

(2011) Luis A. Martinez-Lemus et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1

(2011) Atsushi Shiga et al.   HUMAN MOLECULAR GENETICS

The Proteome of Mouse Brain Microvessel Membranes and Basal Lamina

(2011) Hyun Bae Chun et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Matrisome:In SilicoDefinition andIn VivoCharacterization by Proteomics of Normal and Tumor Extracellular Matrices

(2011) Alexandra Naba et al.   MOLECULAR & CELLULAR PROTEOMICS

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth

(2011) S. Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease

(2011) J. F. Arboleda-Velasquez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitronectin in Vascular Context: Facets of a Multitalented Matricellular Protein

(2011) Klaus Preissner et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions

(2011) R. O. Hynes et al.   Cold Spring Harbor Perspectives in Biology

Fibronectins, Their Fibrillogenesis, and In Vivo Functions

(2011) J. E. Schwarzbauer et al.   Cold Spring Harbor Perspectives in Biology

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity

(2010) Keith Brew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pathogenesis of CADASIL

(2010) Anne Joutel   BIOESSAYS

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Mapping structural landmarks, ligand binding sites, and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions, and variation in phenotypes in inherited diseases affecting basement membranes

(2010) J. Des Parkin et al.   HUMAN MUTATION

Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease

(2010) Anne Joutel et al.   JOURNAL OF CLINICAL INVESTIGATION

Prediction of Extracellular Matrix Proteins Based on Distinctive Sequence and Domain Characteristics

(2010) Juhyun Jung et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges

(2010) Leonardo Pantoni   LANCET NEUROLOGY

Binding to the Extracellular Matrix and Proteolytic Processing: Two Key Mechanisms Regulating Vascular Endothelial Growth Factor Action

(2010) Napoleone Ferrara   MOLECULAR BIOLOGY OF THE CELL

The Collagen Family

(2010) S. Ricard-Blum   Cold Spring Harbor Perspectives in Biology

Basement Membranes: Cell Scaffoldings and Signaling Platforms

(2010) P. D. Yurchenco   Cold Spring Harbor Perspectives in Biology

Extracellular matrix alterations in hypertensive vascular remodeling

(2009) Catherine A. Lemarié et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

CADASIL

(2009) Hugues Chabriat et al.   LANCET NEUROLOGY

FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation

(2009) Kimberly A Aldinger et al.   NATURE GENETICS

Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain

(2009) Chuan Wu et al.   NATURE MEDICINE

Association of HTRA1 Mutations and Familial Ischemic Cerebral Small-Vessel Disease

(2009) Kenju Hara et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Hypertension and Cerebrovascular Dysfunction

(2008) Costantino Iadecola et al.   Cell Metabolism

Mammalian collagen IV

(2008) Jamshid Khoshnoodi et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Nidogens—Extracellular matrix linker molecules

(2008) Matthew S.P. HO et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Extensive loss of arterial medial smooth muscle cells and mural extracellular matrix in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL)

(2007) Takashi Oide et al.   NEUROPATHOLOGY