Development of physiologically based pharmacokinetic model to evaluate the relative systemic exposure to quetiapine after administration of IR and XR formulations to adults, children and adolescents

Pharmacokinetic profile of the extended-release formulation of quetiapine fumarate (quetiapine XR): clinical implications

(2013) Khanh Bui et al.   CURRENT MEDICAL RESEARCH AND OPINION

Influence of ABCB1 and CYP3A5 genetic polymorphisms on the pharmacokinetics of quetiapine in healthy volunteers

(2013) Kyoung-Ah Kim et al.   Pharmacogenetics and Genomics

The Role of Physiologically Based Pharmacokinetic Modeling in Regulatory Review

(2012) S-M Huang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology

(2012) A Rostami-Hodjegan   CLINICAL PHARMACOLOGY & THERAPEUTICS

Regulatory Experience With Physiologically Based Pharmacokinetic Modeling for Pediatric Drug Trials

(2012) R Leong et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Study of pH-dependent solubility of organic bases. Revisit of Henderson-Hasselbalch relationship

(2010) Gergely Völgyi et al.   ANALYTICA CHIMICA ACTA

Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate

(2010) Yun W. Alelyunas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

(2010) P Zhao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice

(2010) Trevor N. Johnson et al.   PEDIATRIC ANESTHESIA

Population-Based Mechanistic Prediction of Oral Drug Absorption

(2009) Masoud Jamei et al.   AAPS Journal

The In Silico Child: Using Simulation to Guide Pediatric Drug Development and Manage Pediatric Pharmacotherapy

(2009) Stephanie Läer et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Relationship between Brain Tissue Partitioning and Microemulsion Retention Factors of CNS Drugs

(2009) Hong Wan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Steady-State Pharmacokinetic, Safety, and Tolerability Profiles of Quetiapine, Norquetiapine, and Other Quetiapine Metabolites in Pediatric and Adult Patients with Psychotic Disorders

(2008) Helen R. Winter et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Pharmacokinetic profiles of extended release quetiapine fumarate compared with quetiapine immediate release

(2008) Carlos Figueroa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY