Pediatric Development of Bosentan Facilitated by Modeling and Simulation

Haemodynamic characterisation and heart catheterisation complications in children with pulmonary hypertension: Insights from the Global TOPP Registry (tracking outcomes and practice in paediatric pulmonary hypertension)

(2016) M. Beghetti et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo-Controlled Exploratory Trial

(2016) Robin H. Steinhorn et al.   JOURNAL OF PEDIATRICS

Effect of Kidney Function on Drug Kinetics and Dosing in Neonates, Infants, and Children

(2015) Frederique Rodieux et al.   CLINICAL PHARMACOKINETICS

Prediction of drug clearance in children

(2015) Frantz Foissac et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Management of Pulmonary Arterial Hypertension

(2015) Vallerie V. McLaughlin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability

(2014) Manoranjenni Chetty et al.   Frontiers in Pharmacology

Diagnostic evaluation of paediatric pulmonary hypertension in current clinical practice

(2013) Maurice Beghetti et al.   EUROPEAN RESPIRATORY JOURNAL

New Trial Designs and Potential Therapies for Pulmonary Artery Hypertension

(2013) Mardi Gomberg-Maitland et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Definitions and Diagnosis of Pulmonary Hypertension

(2013) Marius M. Hoeper et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pediatric Pulmonary Hypertension

(2013) D. Dunbar Ivy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Dose Selection Based on Physiologically Based Pharmacokinetic (PBPK) Approaches

(2012) Hannah M. Jones et al.   AAPS Journal

Pulmonary arterial hypertension: a comparison between children and adults

(2011) R. J. Barst et al.   EUROPEAN RESPIRATORY JOURNAL

Extrapolation of Adult Data and Other Data in Pediatric Drug-Development Programs

(2011) J. Dunne et al.   PEDIATRICS

A Computational Systems Biology Software Platform for Multiscale Modeling and Simulation: Integrating Whole-Body Physiology, Disease Biology, and Molecular Reaction Networks

(2011) Thomas Eissing   Frontiers in Physiology

Long-Term Outcomes in Children With Pulmonary Arterial Hypertension Treated With Bosentan in Real-World Clinical Settings

(2010) D. Dunbar Ivy et al.   AMERICAN JOURNAL OF CARDIOLOGY

Critique of the Two-Fold Measure of Prediction Success for Ratios: Application for the Assessment of Drug-Drug Interactions

(2010) E. J. Guest et al.   DRUG METABOLISM AND DISPOSITION

Confidence Assessment of the Simcyp Time-Based Approach and a Static Mathematical Model in Predicting Clinical Drug-Drug Interactions for Mechanism-Based CYP3A Inhibitors

(2010) Y.-H. Wang   DRUG METABOLISM AND DISPOSITION

Pharmacokinetic and clinical profile of a novel formulation of bosentan in children with pulmonary arterial hypertension: the FUTURE-1 study

(2009) Maurice Beghetti et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Bosentan in Pediatric Patients with Pulmonary Arterial Hypertension

(2009) Maurice Beghetti   Current Vascular Pharmacology

Methods for Predicting In Vivo Pharmacokinetics Using Data from In Vitro Assays

(2008) J. Houston et al.   CURRENT DRUG METABOLISM