Regulatory Experience With Physiologically Based Pharmacokinetic Modeling for Pediatric Drug Trials

Pediatric Dose Selection

(2010) D R Abernethy et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

(2010) P Zhao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Knowledge-driven approaches for the guidance of first-in-children dosing

(2010) Andrea N. Edginton   PEDIATRIC ANESTHESIA

Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice

(2010) Trevor N. Johnson et al.   PEDIATRIC ANESTHESIA

The In Silico Child: Using Simulation to Guide Pediatric Drug Development and Manage Pediatric Pharmacotherapy

(2009) Stephanie Läer et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Leveraging prior quantitative knowledge in guiding pediatric drug development: a case study

(2009) Pravin R. Jadhav et al.   PHARMACEUTICAL STATISTICS

Off-label drug use among hospitalised children: identifying areas with the highest need for research

(2008) Linda Hsien et al.   PHARMACY WORLD & SCIENCE

The problems in scaling adult drug doses to children

(2007) T N Johnson   ARCHIVES OF DISEASE IN CHILDHOOD