Development of a Physiologically Based Model for Oseltamivir and Simulation of Pharmacokinetics in Neonates and Infants

Surge in Expression of Carboxylesterase 1 During the Post-neonatal Stage Enables a Rapid Gain of the Capacity to Activate the Anti-influenza Prodrug Oseltamivir

(2011) Deshi Shi et al.   JOURNAL OF INFECTIOUS DISEASES

Practical lessons from the first outbreaks: Clinical presentation, obstacles, and management strategies for severe pandemic (pH1N1) 2009 influenza pneumonitis

(2010) Duane J. Funk et al.   CRITICAL CARE MEDICINE

Pharmacokinetics of oseltamivir: an oral antiviral for the treatment and prophylaxis of influenza in diverse populations

(2010) B. E. Davies   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Oseltamivir Dosing for Influenza Infection in Premature Neonates

(2010) Edward P. Acosta et al.   JOURNAL OF INFECTIOUS DISEASES

Proposals for model-based paediatric medicinal development within the current European Union regulatory framework

(2009) Efthymios Manolis et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Can we get the necessary clinical trials in children and avoid the unnecessary ones?

(2009) Kalle Hoppu   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Human carboxylesterases HCE1 and HCE2: Ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin

(2008) Dongfang Yang et al.   BIOCHEMICAL PHARMACOLOGY

Limited Brain Distribution of [3R,4R,5S]-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate Phosphate (Ro 64-0802), a Pharmacologically Active Form of Oseltamivir, by Active Efflux across the Blood-Brain Barrier Mediated by Organic Anion Transporter 3 (Oat3/Slc22a8) and Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4)

(2008) A. Ose et al.   DRUG METABOLISM AND DISPOSITION

Population Pharmacokinetics of Oseltamivir When Coadministered With Probenecid

(2008) Craig R. Rayner et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Applications of Physiologically Based Absorption Models in Drug Discovery and Development

(2008) Neil Parrott et al.   MOLECULAR PHARMACEUTICS

The problems in scaling adult drug doses to children

(2007) T N Johnson   ARCHIVES OF DISEASE IN CHILDHOOD