Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response

Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteins

(2011) Oishee Chakrabarti et al.   MOLECULAR BIOLOGY OF THE CELL

Protein targeting and degradation are coupled for elimination of mislocalized proteins

(2011) Tara Hessa et al.   NATURE

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

(2011) Pádraig D'Arcy et al.   NATURE MEDICINE

Eeyarestatin 1 Interferes with Both Retrograde and Anterograde Intracellular Trafficking Pathways

(2011) Mina-Olga Aletrari et al.   PLoS One

Enzymatic Blockade of the Ubiquitin-Proteasome Pathway

(2011) Robert Ernst et al.   PLOS BIOLOGY

Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein

(2010) Neena S. Rane et al.   JOURNAL OF CELL BIOLOGY

Up-regulation of endoplasmic reticulum stress-related genes during the early phase of treatment of cultured cortical neurons by the proteasomal inhibitor lactacystin

(2010) Meng Shyan Choy et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

(2010) R. Luke Wiseman et al.   MOLECULAR CELL

The ERAD Inhibitor Eeyarestatin I Is a Bifunctional Compound with a Membrane-Binding Domain and a p97/VCP Inhibitory Group

(2010) Qiuyan Wang et al.   PLoS One

Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation

(2010) S. A. Hasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Depletion of Mahogunin by Cytosolically Exposed Prion Protein Contributes to Neurodegeneration

(2009) Oishee Chakrabarti et al.   CELL

Differences in endoplasmic-reticulum quality control determine the cellular response to disease-associated mutants of proteolipid protein

(2009) P. Roboti et al.   JOURNAL OF CELL SCIENCE

Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum

(2009) B. C. S. Cross et al.   JOURNAL OF CELL SCIENCE

Apratoxin A Reversibly Inhibits the Secretory Pathway by Preventing Cotranslational Translocation

(2009) Y. Liu et al.   MOLECULAR PHARMACOLOGY

Delivering proteins for export from the cytosol

(2009) Benedict C. S. Cross et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells

(2009) R Kar et al.   ONCOGENE

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

(2009) Q. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Stress in Disease Pathogenesis

(2008) Jonathan H. Lin et al.   Annual Review of Pathology-Mechanisms of Disease

Segregation and rapid turnover of EDEM1 by an autophagy-like mechanism modulates standard ERAD and folding activities

(2008) Tito Calì et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SRP Keeps Polypeptides Translocation-Competent by Slowing Translation to Match Limiting ER-Targeting Sites

(2008) Asvin K.K. Lakkaraju et al.   CELL

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

(2008) H. Nishitoh et al.   GENES & DEVELOPMENT

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

(2008) M. L. Duennwald et al.   GENES & DEVELOPMENT

Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system

(2008) Maria Berndtsson et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of p97-dependent Protein Degradation by Eeyarestatin I

(2008) Qiuyan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retrotranslocation of Prion Proteins from the Endoplasmic Reticulum by Preventing GPI Signal Transamidation

(2008) Aarthi Ashok et al.   MOLECULAR BIOLOGY OF THE CELL

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE