Emerging role of the Jun N-terminal kinase interactome in human health

Stimulation of Insulin Signaling and Inhibition of JNK-AP1 Activation Protect Cells from Amyloid-β-Induced Signaling Dysregulation and Inflammatory Response

(2018) Michelle Bamji-Mirza et al.   JOURNAL OF ALZHEIMERS DISEASE

Core engagement with β-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation

(2017) Punita Kumari et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

(2017) Thomas J. Cahill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of arrestin-3 activation and signaling

(2017) Qiuyan Chen et al.   Nature Communications

JNK at the crossroad of obesity, insulin resistance, and cell stress response

(2017) Giovanni Solinas et al.   Molecular Metabolism

JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia

(2016) C Zhou et al.   LEUKEMIA

Functional competence of a partially engaged GPCR–β-arrestin complex

(2016) Punita Kumari et al.   Nature Communications

Tau and spectraplakins promote synapse formation and maintenance through Jun kinase and neuronal trafficking

(2016) Andre Voelzmann et al.   eLife

Peptide mini-scaffold facilitates JNK3 activation in cells

(2016) Xuanzhi Zhan et al.   Scientific Reports

Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice

(2015) Qiong Zhou et al.   ANNALS OF NEUROLOGY

β-arrestin Promotes c-Jun N-terminal Kinase Mediated Apoptosis via a GABABR·β-arrestin·JNK Signaling Module

(2014) Jin-Xia Wu et al.   Asian Pacific Journal of Cancer Prevention

RETRACTED: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

(2014) Satish Srinivas Kitambi et al.   CELL

A Protoberberine Derivative HWY336 Selectively Inhibits MKK4 and MKK7 in Mammalian Cells: The Importance of Activation Loop on Selectivity

(2014) Namil Kim et al.   PLoS One

A Fasting-Responsive Signaling Pathway that Extends Life Span in C. elegans

(2013) Masaharu Uno et al.   Cell Reports

Modulation of methuselah expression targeted toDrosophilainsulin-producing cells extends life and enhances oxidative stress resistance

(2012) Luis E. D. Gimenez et al.   AGING CELL

JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic

(2012) Bailing Chen et al.   CELL CYCLE

Normalization and Statistical Analysis of Multiplexed Bead-based Immunoassay Data Using Mixed-effects Modeling

(2012) David C. Clarke et al.   MOLECULAR & CELLULAR PROTEOMICS

JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides

(2012) Sung Ok Yoon et al.   NEURON

JNK-Dependent Stat3 Phosphorylation Contributes to Akt Activation in Response to Arsenic Exposure

(2012) J. Liu et al.   TOXICOLOGICAL SCIENCES

7,3′,4′-Trihydroxyisoflavone, a Metabolite of the Soy Isoflavone Daidzein, Suppresses Ultraviolet B-induced Skin Cancer by Targeting Cot and MKK4

(2011) Dong Eun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Twenty years of Alzheimer’s disease-causing mutations

(2011) Alison Goate et al.   JOURNAL OF NEUROCHEMISTRY

Antitumor Activity of a Novel Oncrasin Analogue Is Mediated by JNK Activation and STAT3 Inhibition

(2011) Wei Guo et al.   PLoS One

Inhibition of JNK phosphorylation reverses memory deficit induced by β-amyloid (1–42) associated with decrease of apoptotic factors

(2010) Mahmoudreza Ramin et al.   BEHAVIOURAL BRAIN RESEARCH

Elucidation of Inositol Hexaphosphate and Heparin Interaction Sites and Conformational Changes in Arrestin-1 by Solution Nuclear Magnetic Resonance

(2010) Tiandi Zhuang et al.   BIOCHEMISTRY

Specific regulation of JNK signalling by the novel rat MKK7γ1 isoform

(2010) Wiebke Haeusgen et al.   CELLULAR SIGNALLING

JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

(2010) Giovanni Solinas et al.   FASEB JOURNAL

POSH promotes cell survival inDrosophilaand in human RASF cells

(2010) Manabu Tsuda et al.   FEBS LETTERS

Dynamic Modeling and Simulation of JNK and P38 Kinase Cascades With Feedbacks and Crosstalks

(2010) P Sundaramurthy et al.   IEEE TRANSACTIONS ON NANOBIOSCIENCE

cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance

(2010) Guadalupe Sabio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Insulin signaling meets mitochondria in metabolism

(2010) Zhiyong Cheng et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Synergistic induction of cell death in liver tumor cells by TRAIL and chemotherapeutic drugs via the BH3-only proteins Bim and Bid

(2010) S Schneider-Jakob et al.   Cell Death & Disease

Jnk signaling pathway-mediated regulation of Stat3 activation is linked to the development of doxorubicin resistance in cancer cell lines

(2009) Ju-Hwa Kim et al.   BIOCHEMICAL PHARMACOLOGY

Cardiac-Specific Deletion of Mkk4 Reveals Its Role in Pathological Hypertrophic Remodeling but Not in Physiological Cardiac Growth

(2009) Wei Liu et al.   CIRCULATION RESEARCH

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Adipose tissue as an endocrine organ

(2009) Sandra Galic et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease

(2009) Alessio Colombo et al.   NEUROBIOLOGY OF DISEASE

The Logic of EGFR/ErbB Signaling: Theoretical Properties and Analysis of High-Throughput Data

(2009) Regina Samaga et al.   PLoS Computational Biology

DNA Damage-Dependent Translocation of B23 and p19ARF Is Regulated by the Jun N-Terminal Kinase Pathway

(2008) O. Yogev et al.   CANCER RESEARCH

Transcriptional repression of c-Jun's E3 ubiquitin ligases contributes to c-Jun induction by UV

(2008) Shira Anzi et al.   CELLULAR SIGNALLING

Insulin sensitivity: modulation by nutrients and inflammation

(2008) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Repeated swim stress induces kappa opioid-mediated activation of extracellular signal-regulated kinase 1/2

(2008) Michael R. Bruchas et al.   NEUROREPORT

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE