Metabolic implications of hypoxia and pseudohypoxia in pheochromocytoma and paraganglioma

New HIF2α inhibitors: potential implications as therapeutics for advanced pheochromocytomas and paragangliomas

(2017) Rodrigo Almeida Toledo   ENDOCRINE-RELATED CANCER

Hypoxia, pseudohypoxia and cellular differentiation

(2017) Sofie Mohlin et al.   EXPERIMENTAL CELL RESEARCH

New horizons in hypoxia signaling pathways

(2017) Christopher W. Pugh et al.   EXPERIMENTAL CELL RESEARCH

PheoSeq

(2017) Maria Currás-Freixes et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors

(2017) Doriane Lorendeau et al.   METABOLIC ENGINEERING

Reactive Oxygen and Nitrogen Species in Carcinogenesis: Implications of Oxidative Stress on the Progression and Development of Several Cancer Types

(2017) Joanna Kruk et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks

(2017) Mircea Ivan et al.   MOLECULAR CELL

Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice

(2017) Sabine Harlander et al.   NATURE MEDICINE

MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma

(2017) Sean T. Bailey et al.   Nature Communications

Mitochondrial metabolites: undercover signalling molecules

(2017) Christian Frezza   Interface Focus

A computational analysis of S-(2-succino)cysteine sites in proteins

(2016) Gianluca Miglio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

(2016) Kimberly J. Briggs et al.   CELL

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions

(2016) Stephen P. Burr et al.   Cell Metabolism

Pheochromocytoma and paraganglioma

(2016) Nelly Burnichon et al.   CURRENT OPINION IN ONCOLOGY

Hypoxia Pathway Mutations in Pheochromocytomas and Paragangliomas

(2016) Diana Amorim-Pires et al.   CYTOGENETIC AND GENOME RESEARCH

From Nf1 to Sdhb knockout: Successes and failures in the quest for animal models of pheochromocytoma

(2016) Charlotte Lepoutre-Lussey et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

O 2 sensing, mitochondria and ROS signaling: The fog is lifting

(2016) Gregory B. Waypa et al.   MOLECULAR ASPECTS OF MEDICINE

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2

(2016) Natalie J. German et al.   MOLECULAR CELL

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

(2016) Bernard Thienpont et al.   NATURE

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

The hypoxia-inducible factor (HIF) couples immunity with metabolism

(2016) Doug N. Halligan et al.   SEMINARS IN IMMUNOLOGY

Genome-wide analysis of HIF-2α chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions

(2016) Meng-Chang Lee et al.   Scientific Reports

Hypoxia-Inducible Factor 2α Mutation-Related Paragangliomas Classify as Discrete Pseudohypoxic Subcluster

(2016) Stephanie M.J. Fliedner et al.   NEOPLASIA

Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation

(2016) Gibok Lee et al.   Scientific Reports

Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling

(2015) M. Carmen Fernández-Agüera et al.   Cell Metabolism

15 YEARS OF PARAGANGLIOMA: Pheochromocytoma, paraganglioma and genetic syndromes: a historical perspective

(2015) Tobias Else   ENDOCRINE-RELATED CANCER

Whole-Exome Sequencing Identifies MDH2 as a New Familial Paraganglioma Gene

(2015) Alberto Cascón et al.   JNCI-Journal of the National Cancer Institute

OH, the Places You’ll Go! Hydroxylation, Gene Expression, and Cancer

(2015) Athanasios Ploumakis et al.   MOLECULAR CELL

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

(2015) Simone Cardaci et al.   NATURE CELL BIOLOGY

Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization

(2015) Yuria Saito et al.   NEUROCHEMICAL RESEARCH

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation

(2015) K Kluckova et al.   Cell Death & Disease

Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism

(2015) Charlotte Lussey-Lepoutre et al.   Nature Communications

Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas

(2015) Lauren Fishbein et al.   Nature Communications

Whole-Exome Sequencing Identifies MDH2 as a New Familial Paraganglioma Gene

(2015) Alberto Cascón et al.   JNCI-Journal of the National Cancer Institute

Metabolome Profiling by HRMAS NMR Spectroscopy of Pheochromocytomas and Paragangliomas Detects SDH Deficiency: Clinical and Pathophysiological Implications

(2015) Alessio Imperiale et al.   NEOPLASIA

Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia

(2014) D. Macias et al.   EMBO Molecular Medicine

Frequent EPAS1/HIF2α exons 9 and 12 mutations in non-familial pheochromocytoma

(2014) Jenny Welander et al.   ENDOCRINE-RELATED CANCER

Telomerase reverse transcriptase promoter mutations in tumors originating from the adrenal gland and extra-adrenal paraganglia

(2014) Thomas G Papathomas et al.   ENDOCRINE-RELATED CANCER

Oncometabolites-driven tumorigenesis: From genetics to targeted therapy

(2014) Aurélie Morin et al.   INTERNATIONAL JOURNAL OF CANCER

The Oncometabolite Fumarate Promotes Pseudohypoxia Through Noncanonical Activation of NF-κB Signaling

(2014) Karthigayan Shanmugasundaram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Krebs Cycle Metabolite Profiling for Identification and Stratification of Pheochromocytomas/Paragangliomas due to Succinate Dehydrogenase Deficiency

(2014) Susan Richter et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases

(2014) Hanna Tarhonskaya et al.   Nature Communications

SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma

(2013) Eric Letouzé et al.   CANCER CELL

In vivo and in vitro oncogenic effects of HIF2A mutations in pheochromocytomas and paragangliomas

(2013) Rodrigo A Toledo et al.   ENDOCRINE-RELATED CANCER

Succinate-to-Fumarate Ratio as a New Metabolic Marker to Detect the Presence ofSDHB/D-related Paraganglioma: Initial Experimental and Ex Vivo Findings

(2013) Nikoletta Lendvai et al.   ENDOCRINOLOGY

Tumoral EPAS1 (HIF2A) mutations explain sporadic pheochromocytoma and paraganglioma in the absence of erythrocytosis

(2013) Iñaki Comino-Méndez et al.   HUMAN MOLECULAR GENETICS

Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas

(2013) Luis Jaime Castro-Vega et al.   HUMAN MOLECULAR GENETICS

Hypoxia-Inducible Factor Signaling in Pheochromocytoma: Turning the Rudder in the Right Direction

(2013) I. Jochmanova et al.   JNCI-Journal of the National Cancer Institute

Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes

(2013) Cullen M Taniguchi et al.   NATURE MEDICINE

Rare insights into cancer biology

(2013) J Adam et al.   ONCOGENE

Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor

(2013) J. Keith Killian et al.   Cancer Discovery

A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia

(2013) Julie Adam et al.   Cell Reports

Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency

(2013) Nicola Ternette et al.   Cell Reports

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions

(2012) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Impairment of Catecholaminergic Cell Maturation and Survival by Genetic Mitochondrial Complex II Dysfunction

(2012) B. Diaz-Castro et al.   MOLECULAR AND CELLULAR BIOLOGY

SomaticHIF2AGain-of-Function Mutations in Paraganglioma with Polycythemia

(2012) Zhengping Zhuang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Warburg Effect’s Manifestation in Aggressive Pheochromocytomas and Paragangliomas: Insights from a Mouse Cell Model Applied to Human Tumor Tissue

(2012) Stephanie M. J. Fliedner et al.   PLoS One

Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels

(2012) Hiroshi Harada et al.   Nature Communications

Succination of Keap1 and Activation of Nrf2-Dependent Antioxidant Pathways in FH-Deficient Papillary Renal Cell Carcinoma Type 2

(2011) Lisa Kinch et al.   CANCER CELL

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

(2011) Christian Frezza et al.   NATURE

Ambient Oxygen Promotes Tumorigenesis

(2011) Ho Joong Sung et al.   PLoS One

SDHA is a tumor suppressor gene causing paraganglioma

(2010) Nelly Burnichon et al.   HUMAN MOLECULAR GENETICS

HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression

(2010) Daniel A. Tennant et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Research Resource: Transcriptional Profiling Reveals Different Pseudohypoxic Signatures in SDHB and VHL-Related Pheochromocytomas

(2010) Elena López-Jiménez et al.   MOLECULAR ENDOCRINOLOGY

Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling

(2009) Andrew G. Cox et al.   BIOCHEMICAL JOURNAL

The Warburg Effect Is Genetically Determined in Inherited Pheochromocytomas

(2009) Judith Favier et al.   PLoS One

HIF2  inhibition promotes p53 pathway activity, tumor cell death, and radiation responses

(2009) J. A. Bertout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

(2009) H.-X. Hao et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Succination of Proteins by Fumarate

(2008) Matthew Blatnik et al.   Annals of the New York Academy of Sciences

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Cells Silenced for SDHB Expression Display Characteristic Features of the Tumor Phenotype

(2008) A. M. Cervera et al.   CANCER RESEARCH

Hypoxia-Inducible Factor-2α Transactivates Abcg2 and Promotes Cytoprotection in Cardiac Side Population Cells

(2008) Cindy M. Martin et al.   CIRCULATION RESEARCH

Methylation of the p16INK4A promoter is associated with malignant behavior in abdominal extra-adrenal paragangliomas but not pheochromocytomas

(2008) N B Kiss et al.   ENDOCRINE-RELATED CANCER