Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors

Title

Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors

Authors

Keywords

Succinate dehydrogenase, Complex I of the electron transport chain, Mitochondrial respiration, Reductive glutamine metabolism, Pyruvate carboxylase, C metabolic flux analysis, Paraganglioma, Gastrointestinal stromal tumors, Leigh syndrome, Ataxia, Leukodystrophy, SDH mutations

Journal

METABOLIC ENGINEERING

Volume 43, Issue -, Pages 187-197

Publisher

Elsevier BV

Online

2016-11-13

DOI

10.1016/j.ymben.2016.11.005