Hypoxia-Inducible Factor Signaling in Pheochromocytoma: Turning the Rudder in the Right Direction

In vivo and in vitro oncogenic effects of HIF2A mutations in pheochromocytomas and paragangliomas

(2013) Rodrigo A Toledo et al.   ENDOCRINE-RELATED CANCER

Tumoral EPAS1 (HIF2A) mutations explain sporadic pheochromocytoma and paraganglioma in the absence of erythrocytosis

(2013) Iñaki Comino-Méndez et al.   HUMAN MOLECULAR GENETICS

First Report of Bilateral Pheochromocytoma in the Clinical Spectrum ofHIF2A-Related Polycythemia-Paraganglioma Syndrome

(2013) David Taïeb et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Somatic Mutations inH-RASin Sporadic Pheochromocytoma and Paraganglioma Identified by Exome Sequencing

(2013) Joakim Crona et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

New Syndrome of Paraganglioma and Somatostatinoma Associated With Polycythemia

(2013) Karel Pacak et al.   JOURNAL OF CLINICAL ONCOLOGY

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

(2013) Jamie L. Rogers et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

(2013) Thomas H Scheuermann et al.   Nature Chemical Biology

Proteostasis Modulators Prolong Missense VHL Protein Activity and Halt Tumor Progression

(2013) Chunzhang Yang et al.   Cell Reports

MAX and MYC: A Heritable Breakup

(2012) A. Cascon et al.   CANCER RESEARCH

MAX Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma

(2012) N. Burnichon et al.   CLINICAL CANCER RESEARCH

Missense mutations in the human SDHB gene increase protein degradation without altering intrinsic enzymatic function

(2012) Chunzhang Yang et al.   FASEB JOURNAL

An Update on the Genetics of Paraganglioma, Pheochromocytoma, and Associated Hereditary Syndromes

(2012) A.-P. Gimenez-Roqueplo et al.   HORMONE AND METABOLIC RESEARCH

Effects of hypoxia and HIFs on cancer metabolism

(2012) Vera Mucaj et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

A novel EPAS1/HIF2A germline mutation in a congenital polycythemia with paraganglioma

(2012) Felipe R. Lorenzo et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Untuning the tumor metabolic machine: HIF-α: pro- and antitumorigenic?

(2012) Regina M Young et al.   NATURE MEDICINE

SomaticHIF2AGain-of-Function Mutations in Paraganglioma with Polycythemia

(2012) Zhengping Zhuang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions

(2012) Alexander Laemmle et al.   PLoS One

Passing the baton: the HIF switch

(2012) Mei Yee Koh et al.   TRENDS IN BIOCHEMICAL SCIENCES

The genetics of paragangliomas

(2012) N. Burnichon et al.   European Annals of Otorhinolaryngology-Head and Neck Diseases

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

The Hypoxia-Associated Factor Switches Cells from HIF-1 - to HIF-2 -Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion

(2011) M. Y. Koh et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

(2011) Minna Heikkilä et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Measurements of Plasma Methoxytyramine, Normetanephrine, and Metanephrine as Discriminators of Different Hereditary Forms of Pheochromocytoma

(2011) G. Eisenhofer et al.   CLINICAL CHEMISTRY

Minireview: The Busy Road to Pheochromocytomas and Paragangliomas Has a New Member, TMEM127

(2011) Shoulei Jiang et al.   ENDOCRINOLOGY

Hypoxia Increases Sirtuin 1 Expression in a Hypoxia-inducible Factor-dependent Manner

(2011) Rui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma

(2011) Iñaki Comino-Méndez et al.   NATURE GENETICS

Oxygen Sensing, Homeostasis, and Disease

(2011) Gregg L. Semenza   NEW ENGLAND JOURNAL OF MEDICINE

Reciprocal influence of the p53 and the hypoxic pathways

(2011) A Sermeus et al.   Cell Death & Disease

Genetic and Functional Studies Implicate HIF1  as a 14q Kidney Cancer Suppressor Gene

(2011) C. Shen et al.   Cancer Discovery

Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets

(2010) Toshio Miyata et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Neurofibromatosis type 1 (NF1) and pheochromocytoma: prevalence, clinical and cardiovascular aspects

(2010) Laura Zinnamosca et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Pheochromocytomas: The (pseudo)-hypoxia hypothesis

(2010) Judith Favier et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Catecholamine metabolomic and secretory phenotypes in phaeochromocytoma

(2010) G. Eisenhofer et al.   ENDOCRINE-RELATED CANCER

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility

(2010) D. Astuti et al.   ENDOCRINE-RELATED CANCER

SDHA is a tumor suppressor gene causing paraganglioma

(2010) Nelly Burnichon et al.   HUMAN MOLECULAR GENETICS

Hypoxia-inducible factor (HIF)-3α is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2

(2010) Annika Pasanen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of mTORC1 by the Rab and Arf GTPases

(2010) Li Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

(2010) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRAF V600E mutation influences hypoxia-inducible factor-1α expression levels in papillary thyroid cancer

(2010) Monica Zerilli et al.   MODERN PATHOLOGY

The Late Endosome is Essential for mTORC1 Signaling

(2010) Rory J. Flinn et al.   MOLECULAR BIOLOGY OF THE CELL

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Research Resource: Transcriptional Profiling Reveals Different Pseudohypoxic Signatures in SDHB and VHL-Related Pheochromocytomas

(2010) Elena López-Jiménez et al.   MOLECULAR ENDOCRINOLOGY

Germline mutations in TMEM127 confer susceptibility to pheochromocytoma

(2010) Yuejuan Qin et al.   NATURE GENETICS

Regulation of Gene Expression in Hepatic Cells by the Mammalian Target of Rapamycin (mTOR)

(2010) Rosa H. Jimenez et al.   PLoS One

Contrasting clinical manifestations of SDHB and VHL associated chromaffin tumours

(2009) Umasuthan Srirangalingam et al.   ENDOCRINE-RELATED CANCER

Pheochromocytomas: From Genetic Diversity to New Paradigms

(2009) Y. Qin et al.   HORMONE AND METABOLIC RESEARCH

Tumor risks and genotype–phenotype–proteotype analysis in 358 patients with germline mutations inSDHBandSDHD

(2009) Christopher J. Ricketts et al.   HUMAN MUTATION

SEPT9_v1 Up-regulates Hypoxia-inducible Factor 1 by Preventing Its RACK1-mediated Degradation

(2009) Sharon Amir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

(2009) David R. Mole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of HIF-1 inhibitors for cancer therapy

(2009) Barbara Onnis et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Clinically Guided Genetic Screening in a Large Cohort of Italian Patients with Pheochromocytomas and/or Functional or Nonfunctional Paragangliomas

(2009) Massimo Mannelli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Succinate Dehydrogenase Genetic Testing in a Large Prospective Series of Patients with Paragangliomas

(2009) Nelly Burnichon et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Isocitrate Dehydrogenase Mutations Are Rare in Pheochromocytomas and Paragangliomas

(2009) José Gaal et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Succinate dehydrogenase subunit B (SDHB) gene deletion associated with a composite paraganglioma/neuroblastoma

(2009) R Armstrong et al.   JOURNAL OF MEDICAL GENETICS

An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis

(2009) Francien H van Nederveen et al.   LANCET ONCOLOGY

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

The Warburg Effect Is Genetically Determined in Inherited Pheochromocytomas

(2009) Judith Favier et al.   PLoS One

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

(2009) H.-X. Hao et al.   SCIENCE

Oxygen homeostasis

(2009) Gregg L. Semenza   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

c-Myc and eIF4F Are Components of a Feedforward Loop that Links Transcription and Translation

(2008) C.-J. Lin et al.   CANCER RESEARCH

TORC1 Is Essential for NF1-Associated Malignancies

(2008) Cory M. Johannessen et al.   CURRENT BIOLOGY

The kinesin KIF1B  acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

(2008) S. Schlisio et al.   GENES & DEVELOPMENT

Differential Dependence of Hypoxia-inducible Factors 1α and 2α on mTORC1 and mTORC2

(2008) Alfredo Toschi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Germline SDHB Mutations and Familial Renal Cell Carcinoma

(2008) C. Ricketts et al.   JNCI-Journal of the National Cancer Institute

Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1 , Leading to Its Oxygen-Independent Degradation

(2008) M. Y. Koh et al.   MOLECULAR AND CELLULAR BIOLOGY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

PHD2Mutation and Congenital Erythrocytosis with Paraganglioma

(2008) Charline Ladroue et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1

(2008) J. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pheochromocytoma in MEN 2A Syndrome. Study of 54 Patients

(2008) Jose M. Rodriguez et al.   WORLD JOURNAL OF SURGERY