Different contributions of chemokine N-terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3

Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV

(2017) Yi Zheng et al.   IMMUNITY

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Structural basis of ligand interaction with atypical chemokine receptor 3

(2017) Martin Gustavsson et al.   Nature Communications

New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model

(2016) Andrew B. Kleist et al.   BIOCHEMICAL PHARMACOLOGY

Human herpesvirus 8-encoded chemokine vCCL2/vMIP-II is an agonist of the atypical chemokine receptor ACKR3/CXCR7

(2016) Martyna Szpakowska et al.   BIOCHEMICAL PHARMACOLOGY

Mutational Analysis of Atypical Chemokine Receptor 3 (ACKR3/CXCR7) Interaction with Its Chemokine Ligands CXCL11 and CXCL12

(2016) Besma Benredjem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists

(2016) Yi Zheng et al.   NATURE

Intracellular allosteric antagonism of the CCR9 receptor

(2016) Christine Oswald et al.   NATURE

NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells

(2015) Andrew S. Dixon et al.   ACS Chemical Biology

Forskolin-free cAMP assay for Gi-coupled receptors

(2015) Julie Gilissen et al.   BIOCHEMICAL PHARMACOLOGY

Mode of Binding of the Cyclic Agonist Peptide TC14012 to CXCR7: Identification of Receptor and Compound Determinants

(2015) Nicolas Montpas et al.   BIOCHEMISTRY

Experimental design and analysis and their reporting: new guidance for publication in BJP

(2015) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dual Targeting of the Chemokine Receptors CXCR4 and ACKR3 with Novel Engineered Chemokines

(2015) Melinda S. Hanes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

vCCL2/vMIP-II, the viral master KEYmokine

(2015) M. Szpakowska et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Development of Novel CXC Chemokine Receptor 7 (CXCR7) Ligands: Selectivity Switch from CXCR4 Antagonists with a Cyclic Pentapeptide Scaffold

(2015) Shinya Oishi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor

(2015) J. S. Burg et al.   SCIENCE

Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

(2015) L. Qin et al.   SCIENCE

Neutralising properties of peptides derived from CXCR4 extracellular loops towards CXCL12 binding and HIV-1 infection

(2014) Andy Chevigné et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

New nomenclature for atypical chemokine receptors

(2014) Françoise Bachelerie et al.   NATURE IMMUNOLOGY

Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: Molecular modeling and experimental validation

(2014) Irina Kufareva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biased and G Protein-Independent Signaling of Chemokine Receptors

(2014) Anne Steen et al.   Frontiers in Immunology

Modulation of Circadian Glucocorticoid Oscillation via Adrenal Opioid-CXCR7 Signaling Alters Emotional Behavior

(2013) Yuichi Ikeda et al.   CELL

Endothelial expression of CXCR7 and the regulation of systemic CXCL12 levels

(2013) Robert D. Berahovich et al.   IMMUNOLOGY

Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors

(2013) Sudarshan Rajagopal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Function, diversity and therapeutic potential of the N-terminal domain of human chemokine receptors

(2012) Martyna Szpakowska et al.   BIOCHEMICAL PHARMACOLOGY

A Novel Synthetic Bivalent Ligand To Probe Chemokine Receptor CXCR4 Dimerization and Inhibit HIV-1 Entry

(2012) Won-Tak Choi et al.   BIOCHEMISTRY

Identification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes

(2012) AO Watts et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists

(2012) Maikel Wijtmans et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

Cell Contact-dependent Functional Selectivity of β2-Adrenergic Receptor Ligands in Stimulating cAMP Accumulation and Extracellular Signal-regulated Kinase Phosphorylation

(2012) Ali I. Kaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability

(2012) T. Takekoshi et al.   MOLECULAR CANCER THERAPEUTICS

Engineering and screening the N-terminus of chemokines for drug discovery

(2011) Andy Chevigné et al.   BIOCHEMICAL PHARMACOLOGY

Different Effects of the Different Natural CC Chemokine Receptor 2b Ligands on  -Arrestin Recruitment, G i Signaling, and Receptor Internalization

(2010) Y. A. Berchiche et al.   MOLECULAR PHARMACOLOGY

Constitutive and chemokine-dependent internalization and recycling of CXCR7 in breast cancer cells to degrade chemokine ligands

(2010) K E Luker et al.   ONCOGENE

CXCR7 Functions as a Scavenger for CXCL12 and CXCL11

(2010) Ulrike Naumann et al.   PLoS One

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling

(2009) A. Levoye et al.   BLOOD

Functional Selectivity of Natural and Synthetic Prostaglandin EP4 Receptor Ligands

(2009) M. Leduc et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties

(2009) I. Kalatskaya et al.   MOLECULAR PHARMACOLOGY

 -arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

(2009) S. Rajagopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Chemokine-Guided Cell Migration by Ligand Sequestration

(2008) Bijan Boldajipour et al.   CELL

Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

(2008) C. T. Veldkamp et al.   Science Signaling