Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: Molecular modeling and experimental validation

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

In Silico Analysis Reveals Sequential Interactions and Protein Conformational Changes during the Binding of Chemokine CXCL-8 to Its Receptor CXCR1

(2014) Je-Wen Liou et al.   PLoS One

Multiplex Detection of Homo- and Heterodimerization of G Protein-Coupled Receptors by Proximity Biotinylation

(2014) Elisabeth Steel et al.   PLoS One

Sulfopeptide Probes of the CXCR4/CXCL12 Interface Reveal Oligomer-Specific Contacts and Chemokine Allostery

(2013) Joshua J. Ziarek et al.   ACS Chemical Biology

CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis

(2013) Kosuke Tanegashima et al.   FEBS LETTERS

Transactivation of the PAR1-PAR2 Heterodimer by Thrombin Elicits β-Arrestin-mediated Endosomal Signaling

(2013) Huilan Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of the interactions between CXCR4 and CXCL12/SDF-1 revealed by theoretical approaches

(2013) Lei Xu et al.   Molecular BioSystems

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

(2013) Q. Tan et al.   SCIENCE

Function, diversity and therapeutic potential of the N-terminal domain of human chemokine receptors

(2012) Martyna Szpakowska et al.   BIOCHEMICAL PHARMACOLOGY

Allosteric interactions within the AT1 angiotensin receptor homodimer: Role of the conserved DRY motif

(2012) Bence Szalai et al.   BIOCHEMICAL PHARMACOLOGY

A Novel Synthetic Bivalent Ligand To Probe Chemokine Receptor CXCR4 Dimerization and Inhibit HIV-1 Entry

(2012) Won-Tak Choi et al.   BIOCHEMISTRY

Compound Activity Prediction Using Models of Binding Pockets or Ligand Properties in 3D

(2012) Irina Kufareva et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Modulation of the Interaction between Neurotensin Receptor NTS1 and Gq Protein by Lipid

(2012) Sayaka Inagaki et al.   JOURNAL OF MOLECULAR BIOLOGY

Pharmacological modulation of chemokine receptor function

(2011) DJ Scholten et al.   BRITISH JOURNAL OF PHARMACOLOGY

Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics

(2011) Lauren T. May et al.   FASEB JOURNAL

CXCR7/CXCR4 Heterodimer Constitutively Recruits β-Arrestin to Enhance Cell Migration

(2011) Fabien M. Décaillot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The CXC Chemokine Receptor 4 Ligands Ubiquitin and Stromal Cell-derived Factor-1α Function through Distinct Receptor Interactions

(2011) Vikas Saini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells

(2011) Brian A Zabel et al.   Molecular Cancer

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways

(2011) L. J. Drury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterophilic chemokine receptor interactions in chemokine signaling and biology

(2010) Birgit K. Kramp et al.   EXPERIMENTAL CELL RESEARCH

CXC Chemokine Receptor 4 Is a Cell Surface Receptor for Extracellular Ubiquitin

(2010) Vikas Saini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Peptidomimetic CXCR4 Antagonist TC14012 Recruits β-Arrestin to CXCR7

(2010) Stéphanie Gravel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monomeric Rhodopsin Is Sufficient for Normal Rhodopsin Kinase (GRK1) Phosphorylation and Arrestin-1 Binding

(2010) Timothy H. Bayburt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation

(2010) A. Rivero-Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling

(2009) A. Levoye et al.   BLOOD

Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the Protean Effects of “Selective” Antagonists

(2009) Denis Sohy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Purification and Functional Reconstitution of Monomeric μ-Opioid Receptors

(2009) Adam J. Kuszak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of the Interaction between Chemokine Stromal Cell-derived Factor-1/CXCL12 and Its G-protein-coupled Receptor CXCR4

(2009) Yutaka Kofuku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidation of CXCR7-Mediated Signaling Events and Inhibition of CXCR4-Mediated Tumor Cell Transendothelial Migration by CXCR7 Ligands

(2009) B. A. Zabel et al.   JOURNAL OF IMMUNOLOGY

AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties

(2009) I. Kalatskaya et al.   MOLECULAR PHARMACOLOGY

CXCR4 dimerization and  -arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome

(2008) B. Lagane et al.   BLOOD

Modulation of chemokine receptor activity through dimerization and crosstalk

(2008) C. L. Salanga et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Imaging chemokine receptor dimerization with firefly luciferase complementation

(2008) Kathryn E. Luker et al.   FASEB JOURNAL

Comparison of the Potential Multiple Binding Modes of Bicyclam, Monocylam, and Noncyclam Small-Molecule CXC Chemokine Receptor 4 Inhibitors

(2008) R. S. Y. Wong et al.   MOLECULAR PHARMACOLOGY

Fluorescence Resonance Energy Transfer Imaging Reveals that Chemokine-Binding Modulates Heterodimers of CXCR4 and CCR5 Receptors

(2008) Nilgun Isik et al.   PLoS One

CXCR4-CCR5: A couple modulating T cell functions

(2008) R. L. Contento et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

(2008) C. T. Veldkamp et al.   Science Signaling

Soft protein-protein docking in internal coordinates

(2002) Juan Fernández-Recio et al.   PROTEIN SCIENCE