Dual Targeting of the Chemokine Receptors CXCR4 and ACKR3 with Novel Engineered Chemokines

Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies

(2015) Irina Kufareva et al.   IMMUNOLOGY AND CELL BIOLOGY

Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor

(2015) J. S. Burg et al.   SCIENCE

Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

(2015) L. Qin et al.   SCIENCE

Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats

(2014) M J Walters et al.   BRITISH JOURNAL OF CANCER

Structural Analysis of a Novel Small Molecule Ligand Bound to the CXCL12 Chemokine

(2014) Emmanuel W. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

A General Method for Site Specific Fluorescent Labeling of Recombinant Chemokines

(2014) Tetsuya Kawamura et al.   PLoS One

The peculiarities of the SDF-1/CXCL12 system: in some cells, CXCR4 and CXCR7 sing solos, in others, they sing duets

(2013) Malte Puchert et al.   CELL AND TISSUE RESEARCH

Endothelial expression of CXCR7 and the regulation of systemic CXCL12 levels

(2013) Robert D. Berahovich et al.   IMMUNOLOGY

Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor

(2013) Peter Ravn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacologically Antagonizing the CXCR4-CXCL12 Chemokine Pathway with AMD3100 Inhibits Sunlight-Induced Skin Cancer

(2013) Seri N.E. Sarchio et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Involvement of CXCR4/CXCR7/CXCL12 Interactions in Inflammatory Bowel Disease

(2013) Lael Werner et al.   Theranostics

An Infernal Trio: The chemokine CXCL12 and its receptors CXCR4 and CXCR7 in tumor biology

(2012) Kirsten Hattermann et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Structure-Function of the G Protein–Coupled Receptor Superfamily

(2012) Vsevolod Katritch et al.   Annual Review of Pharmacology and Toxicology

Cellular Internalization Mechanism and Intracellular Trafficking of Filamentous M13 Phages Displaying a Cell-Penetrating Transbody and TAT Peptide

(2012) Aeyung Kim et al.   PLoS One

The Ability to Enhance the Solubility of Its Fusion Partners Is an Intrinsic Property of Maltose-Binding Protein but Their Folding Is Either Spontaneous or Chaperone-Mediated

(2012) Sreejith Raran-Kurussi et al.   PLoS One

Engineering and screening the N-terminus of chemokines for drug discovery

(2011) Andy Chevigné et al.   BIOCHEMICAL PHARMACOLOGY

The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome

(2011) D. H. McDermott et al.   BLOOD

Pharmacological modulation of chemokine receptor function

(2011) DJ Scholten et al.   BRITISH JOURNAL OF PHARMACOLOGY

The CXCL12/CXCR4 Axis as a Therapeutic Target in Cancer and HIV-1 Infection

(2011) L. Patrussi et al.   CURRENT MEDICINAL CHEMISTRY

A rapid and efficient way to obtain modified chemokines for functional and biophysical studies

(2011) Samantha J. Allen et al.   CYTOKINE

hCXCR1 and hCXCR2 antagonists derived from combinatorial peptide libraries

(2011) Mehdi Houimel et al.   CYTOKINE

Selection of a CXCR4 antagonist from a human heavy chain CDR3-derived phage library

(2011) Andy Chevigné et al.   FEBS Journal

Highly Potent Chimeric Inhibitors Targeting Two Steps of HIV Cell Entry

(2011) Bo Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CXCR7/CXCR4 Heterodimer Constitutively Recruits β-Arrestin to Enhance Cell Migration

(2011) Fabien M. Décaillot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity

(2011) Lillian Cruz-Orengo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peptide Phage Display as a Tool for Drug Discovery: Targeting Membrane Receptors

(2011) Peter Molek et al.   MOLECULES

CXCR4 and CXCR7 Have Distinct Functions in Regulating Interneuron Migration

(2011) Yanling Wang et al.   NEURON

Plerixafor: A chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation after high-dose chemotherapy for non-hodgkin's lymphoma or multiple myeloma

(2010) Michael Steinberg et al.   CLINICAL THERAPEUTICS

Effect of posttranslational processing on the in vitro and in vivo activity of chemokines

(2010) Anneleen Mortier et al.   EXPERIMENTAL CELL RESEARCH

Arrestin-2 Interacts with the Endosomal Sorting Complex Required for Transport Machinery to Modulate Endosomal Sorting of CXCR4

(2010) Rohit Malik et al.   MOLECULAR BIOLOGY OF THE CELL

CXCR7 Functions as a Scavenger for CXCL12 and CXCL11

(2010) Ulrike Naumann et al.   PLoS One

CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

(2010) S. Jahnichen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis

(2010) Xian-Ming Xia   WORLD JOURNAL OF GASTROENTEROLOGY

CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling

(2009) A. Levoye et al.   BLOOD

A novel CXCR4 antagonist derived from human SDF-1β enhances angiogenesis in ischaemic mice

(2009) Yi Tan et al.   CARDIOVASCULAR RESEARCH

Topically Applied Recombinant Chemokine Analogues Fully Protect Macaques from Vaginal Simian‐Human Immunodeficiency Virus Challenge

(2009) Ronald S. Veazey et al.   JOURNAL OF INFECTIOUS DISEASES

Identification of biologically active peptides that inhibit binding of human CXCL8 to its receptors from a random phage-epitope library

(2009) M. Houimel et al.   JOURNAL OF LEUKOCYTE BIOLOGY

AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties

(2009) I. Kalatskaya et al.   MOLECULAR PHARMACOLOGY

 -arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

(2009) S. Rajagopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An in vitro selection strategy for conferring protease resistance to ligand binding peptides

(2009) B. Eldridge et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Heterologous quaternary structure of CXCL12 and its relationship to the CC chemokine family

(2009) James W. Murphy et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

CXCL12 (SDF-1α) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells

(2008) Moran Meiron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Highly potent, fully recombinant anti-HIV chemokines: Reengineering a low-cost microbicide

(2008) H. Gaertner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA