Next-generation, personalised, model-based critical care medicine: a state-of-the art review of in silico virtual patient models, methods, and cohorts, and how to validation them

Generalisability of a Virtual Trials Method for Glycaemic Control in Intensive Care

(2018) Jennifer L. Dickson et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Type-1 Diabetes Patient Decision Simulator for In Silico Testing Safety and Effectiveness of Insulin Treatments

(2018) Martina Vettoretti et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Extrapolation of a non-linear autoregressive model of pulmonary mechanics

(2017) Ruby Langdon et al.   MATHEMATICAL BIOSCIENCES

In silico assessment of biomedical products: The conundrum of rare but not so rare events in two case studies

(2017) Marco Viceconti et al.   PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE

Modeling the Error of the Medtronic Paradigm Veo Enlite Glucose Sensor

(2017) Lyvia Biagi et al.   SENSORS

Closed-loop insulin delivery in inpatients with type 2 diabetes: a randomised, parallel-group trial

(2017) Hood Thabit et al.   Lancet Diabetes & Endocrinology

The Virtual Physiological Human: Ten Years After

(2016) Marco Viceconti et al.   Annual Review of Biomedical Engineering

Day-and-Night Closed-Loop Glucose Control in Patients With Type 1 Diabetes Under Free-Living Conditions: Results of a Single-Arm 1-Month Experience Compared With a Previously Reported Feasibility Study of Evening and Night at Home

(2016) Eric Renard et al.   DIABETES CARE

The Artificial Pancreas in 2016: A Digital Treatment Ecosystem for Diabetes

(2016) Boris Kovatchev et al.   DIABETES CARE

Modeling Transient Disconnections and Compression Artifacts of Continuous Glucose Sensors

(2016) Andrea Facchinetti et al.   Diabetes Technology & Therapeutics

Online Calibration of Glucose Sensors From the Measured Current by a Time-Varying Calibration Function and Bayesian Priors

(2016) Martina Vettoretti et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

One-Day Bayesian Cloning of Type 1 Diabetes Subjects: Toward a Single-Day UVA/Padova Type 1 Diabetes Simulator

(2016) Roberto Visentin et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Improved survival in critically ill patients: are large RCTs more useful than personalized medicine? No

(2016) Jean-Louis Vincent   INTENSIVE CARE MEDICINE

Roadmap for cardiovascular circulation model

(2016) Soroush Safaei et al.   JOURNAL OF PHYSIOLOGY-LONDON

A physiome interoperability roadmap for personalized drug development

(2016) Simon Thomas et al.   Interface Focus

The Human Physiome: how standards, software and innovative service infrastructures are providing the building blocks to make it achievable

(2016) David Nickerson et al.   Interface Focus

Making sense of big data in health research: Towards an EU action plan

(2016) Charles Auffray et al.   Genome Medicine

The Virtual Physiological Human: The Physiome Project Aims to Develop Reproducible, Multiscale Models for Clinical Practice

(2016) Peter Hunter   IEEE Pulse

Safety, efficacy and clinical generalization of the STAR protocol: a retrospective analysis

(2016) Kent W. Stewart et al.   Annals of Intensive Care

Task management skills and their deficiencies during care delivery in simulated medical emergency situation: A classification

(2016) Thierry Morineau et al.   Intensive and Critical Care Nursing

Understanding central venous pressure

(2015) Sheldon Magder   Current Opinion in Critical Care

Multicenter outpatient dinner/overnight reduction of hypoglycemia and increased time of glucose in target with a wearable artificial pancreas using modular model predictive control in adults with type 1 diabetes

(2015) S. Del Favero et al.   DIABETES OBESITY & METABOLISM

Glucose control positively influences patient outcome: A retrospective study

(2015) Sophie Penning et al.   JOURNAL OF CRITICAL CARE

Impact of Haemodialysis on Insulin Kinetics of Acute Kidney Injury Patients in Critical Care

(2015) Ummu K. Jamaludin et al.   Journal of Medical and Biological Engineering

Robust global identifiability theory using potentials—Application to compartmental models

(2015) N. Wongvanich et al.   MATHEMATICAL BIOSCIENCES

Model-based computation of total stressed blood volume from a preload reduction manoeuvre

(2015) Antoine Pironet et al.   MATHEMATICAL BIOSCIENCES

Hyperglycaemic Preterm Babies Have Sex Differences in Insulin Secretion

(2015) Jennifer L. Dickson et al.   Neonatology

Driving Pressure and Survival in the Acute Respiratory Distress Syndrome

(2015) Marcelo B.P. Amato et al.   NEW ENGLAND JOURNAL OF MEDICINE

Home Use of an Artificial Beta Cell in Type 1 Diabetes

(2015) Hood Thabit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Time-Varying Respiratory System Elastance: A Physiological Model for Patients Who Are Spontaneously Breathing

(2015) Yeong Shiong Chiew et al.   PLoS One

Public views on principles for health care priority setting: Findings of a European cross-country study using Q methodology

(2015) Job van Exel et al.   SOCIAL SCIENCE & MEDICINE

Space GlucoseControl system for blood glucose control in intensive care patients - a European multicentre observational study

(2015) Jan Blaha et al.   BMC Anesthesiology

Predictors of the accuracy of pulse-contour cardiac index and suggestion of a calibration-index: a prospective evaluation and validation study

(2015) Wolfgang Huber et al.   BMC Anesthesiology

Breathing Easier: Model-based decision support for respiratory care looks beyond tomorrow.

(2015) Merryn Tawhai et al.   IEEE Pulse

The Open Physiology workflow: modeling processes over physiology circuitboards of interoperable tissue units

(2015) Bernard de Bono et al.   Frontiers in Physiology

OpenCOR: a modular and interoperable approach to computational biology

(2015) Alan Garny et al.   Frontiers in Physiology

2 month evening and night closed-loop glucose control in patients with type 1 diabetes under free-living conditions: a randomised crossover trial

(2015) Jort Kropff et al.   Lancet Diabetes & Endocrinology

Future opportunities and trends for e-infrastructures and life sciences: going beyond the grid to enable life science data analysis

(2015) Afonso M. S. Duarte et al.   Frontiers in Genetics

Use of Pulmonary Artery Catheter in Coronary Artery Bypass Graft. Costs and Long-Term Outcomes

(2015) Fei Xu et al.   PLoS One

Determination of ‘recruited volume’ following a PEEP step is not a measure of lung recruitability

(2014) C. A. STAHL et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Reducing the impact of insulin sensitivity variability on glycaemic outcomes using separate stochastic models within the STAR glycaemic protocol

(2014) Felicity Thomas et al.   Biomedical Engineering Online

The Clinical Utilisation of Respiratory Elastance Software (CURE Soft): a bedside software for real-time respiratory mechanics monitoring and mechanical ventilation management

(2014) Akos Szlavecz et al.   Biomedical Engineering Online

A minimal algorithm for a minimal recruitment model–model estimation of alveoli opening pressure of an acute respiratory distress syndrome (ARDS) lung

(2014) Daniel Redmond et al.   Biomedical Signal Processing and Control

Modeling of Effect of Glucose Sensor Errors on Insulin Dosage and Glucose Bolus Computed by LOGIC-Insulin

(2014) T. Van Herpe et al.   CLINICAL CHEMISTRY

Brain mass estimation by head circumference and body mass methods in neonatal glycaemic modelling and control

(2014) Cameron Allan Gunn et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Safety of Outpatient Closed-Loop Control: First Randomized Crossover Trials of a Wearable Artificial Pancreas

(2014) Boris P. Kovatchev et al.   DIABETES CARE

Assessing Volume Status

(2014) Michael C. Scott et al.   EMERGENCY MEDICINE CLINICS OF NORTH AMERICA

Ten big mistakes in intensive care medicine

(2014) Jean-Louis Vincent et al.   INTENSIVE CARE MEDICINE

Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine

(2014) Maurizio Cecconi et al.   INTENSIVE CARE MEDICINE

Does the achievement of an intermediate glycemic target reduce organ failure and mortality? A post hoc analysis of the Glucontrol trial

(2014) Sophie Penning et al.   JOURNAL OF CRITICAL CARE

Model of glucose sensor error components: identification and assessment for new Dexcom G4 generation devices

(2014) Andrea Facchinetti et al.   MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

Continuous Stroke Volume Estimation from Aortic Pressure Using Zero Dimensional Cardiovascular Model: Proof of Concept Study from Porcine Experiments

(2014) Shun Kamoi et al.   PLoS One

Positive End-Expiratory Pressure and Variable Ventilation in Lung-Healthy Rats under General Anesthesia

(2014) Luciana M. Camilo et al.   PLoS One

Visualisation of time-varying respiratory system elastance in experimental ARDS animal models

(2014) Erwin J van Drunen et al.   BMC Pulmonary Medicine

Choices in fluid type and volume during resuscitation: impact on patient outcomes

(2014) Alena Lira et al.   Annals of Intensive Care

The artificial pancreas: a digital-age treatment for diabetes

(2014) Claudio Cobelli et al.   Lancet Diabetes & Endocrinology

Human factors systems approach to healthcare quality and patient safety

(2013) Pascale Carayon et al.   APPLIED ERGONOMICS

A multi-scale cardiovascular system model can account for the load-dependence of the end-systolic pressure-volume relationship

(2013) Antoine Pironet et al.   Biomedical Engineering Online

Analysis of different model-based approaches for estimating dFRC for real-time application

(2013) Erwin J van Drunen et al.   Biomedical Engineering Online

Expiratory model-based method to monitor ARDS disease state

(2013) Erwin J van Drunen et al.   Biomedical Engineering Online

Effects of Neurally Adjusted Ventilatory Assist (NAVA) levels in non-invasive ventilated patients: titrating NAVA levels with electric diaphragmatic activity and tidal volume matching

(2013) Yeong Chiew et al.   Biomedical Engineering Online

Visualisation of Time-Variant Respiratory System Elastance in ARDS Models

(2013) van E. J. Drunen et al.   Biomedical Engineering-Biomedizinische Technik

Evaluation of a Model-Based Hemodynamic Monitoring Method in a Porcine Study of Septic Shock

(2013) James A. Revie et al.   Computational and Mathematical Methods in Medicine

Impact of sensor and measurement timing errors on model-based insulin sensitivity

(2013) Christopher G. Pretty et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

In Silico Modeling

(2013) Yoram Vodovotz et al.   CRITICAL CARE MEDICINE

Modeling the Glucose Sensor Error

(2013) Andrea Facchinetti et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Efficient computation of interacting model systems

(2013) J. Kretschmer et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Pulmonary Artery Catheters

(2013) Susan K. Frazier et al.   Journal of Cardiovascular Nursing

Reverse engineering and identification in systems biology: strategies, perspectives and challenges

(2013) A. F. Villaverde et al.   Journal of the Royal Society Interface

FieldML, a proposed open standard for the Physiome project for mathematical model representation

(2013) Randall D. Britten et al.   MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

Daily Evolution of Insulin Sensitivity Variability with Respect to Diagnosis in the Critically Ill

(2013) Tamás Ferenci et al.   PLoS One

Individualized PEEP Setting in Subjects With ARDS: A Randomized Controlled Pilot Study

(2013) M.-C. Pintado et al.   Respiratory Care

A vision and strategy for the virtual physiological human: 2012 update

(2013) P. Hunter et al.   Interface Focus

Simulating physiological interactions in a hybrid system of mathematical models

(2013) Jörn Kretschmer et al.   JOURNAL OF CLINICAL MONITORING AND COMPUTING

Reverse Engineering Cellular Networks with Information Theoretic Methods

(2013) Alejandro Villaverde et al.   Cells

Lung elastance and transpulmonary pressure can be determined without using oesophageal pressure measurements

(2012) O. STENQVIST et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Bedside Assessment of Total Systemic Vascular Compliance, Stressed Volume, and Cardiac Function Curves in Intensive Care Unit Patients

(2012) Jacinta J. Maas et al.   ANESTHESIA AND ANALGESIA

Volume-Independent Elastance

(2012) Alysson Roncally Carvalho et al.   ANESTHESIA AND ANALGESIA

Pilot study of a model-based approach to blood glucose control in very-low-birthweight neonates

(2012) Aaron J Le Compte et al.   BMC Pediatrics

Use of models in identification and prediction of physiology in critically ill surgical patients

(2012) M. J. Cohen   BRITISH JOURNAL OF SURGERY

Assessment of ventricular contractility and ventricular-arterial coupling with a model-based sensor

(2012) Thomas Desaive et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Pilot Studies of Wearable Outpatient Artificial Pancreas in Type 1 Diabetes

(2012) C. Cobelli et al.   DIABETES CARE

Real-Time Improvement of Continuous Glucose Monitoring Accuracy: The smart sensor concept

(2012) A. Facchinetti et al.   DIABETES CARE

LOGIC-Insulin Algorithm-Guided Versus Nurse-Directed Blood Glucose Control During Critical Illness: The LOGIC-1 single-center, randomized, controlled clinical trial

(2012) T. Van Herpe et al.   DIABETES CARE

Structural Identifiability and Practical Applicability of an Alveolar Recruitment Model for ARDS Patients

(2012) Christoph Schranz et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

STAR Development and Protocol Comparison

(2012) Liam M. Fisk et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Hypoglycemia and Risk of Death in Critically Ill Patients

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Decision support for optimized blood glucose control and nutrition in a neurotrauma intensive care unit: preliminary results of clinical advice and prediction accuracy of the Glucosafe system

(2012) Ulrike Pielmeier et al.   JOURNAL OF CLINICAL MONITORING AND COMPUTING

Systems modeling and simulation applications for critical care medicine

(2012) Yue Dong et al.   Annals of Intensive Care

Variability of insulin sensitivity during the first 4 days of critical illness: implications for tight glycemic control

(2012) Christopher G Pretty et al.   Annals of Intensive Care

The Physiome Model Repository 2

(2011) T. Yu et al.   BIOINFORMATICS

Validation of a model-based virtual trials method for tight glycemic control in intensive care

(2011) J Geoffrey Chase et al.   Biomedical Engineering Online

Model-based PEEP Optimisation in Mechanical Ventilation

(2011) Yeong Shiong Chiew et al.   Biomedical Engineering Online

Model-based optimal PEEP in mechanically ventilated ARDS patients in the Intensive Care Unit

(2011) Ashwath Sundaresan et al.   Biomedical Engineering Online

A graphical method for practical and informative identifiability analyses of physiological models: A case study of insulin kinetics and sensitivity

(2011) Paul D Docherty et al.   Biomedical Engineering Online

Positive end expiratory pressure in patients with acute respiratory distress syndrome – The past, present and future

(2011) Ashwath Sundaresan et al.   Biomedical Signal Processing and Control

Inotropes and vasopressors: more than haemodynamics!

(2011) Hendrik Bracht et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Intelligent Ventilator (INVENT) project: The role of mathematical models in translating physiological knowledge into clinical practice

(2011) Stephen E. Rees   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Development of blood glucose control for extremely premature infants

(2011) Aaron J. Le Compte et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

A physiological Intensive Control Insulin-Nutrition-Glucose (ICING) model validated in critically ill patients

(2011) Jessica Lin et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Validation of subject-specific cardiovascular system models from porcine measurements

(2011) James A. Revie et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Impact of variation in patient response on model-based control of glycaemia in critically ill patients

(2011) Aaron J. Le Compte et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Dynamically generated models for medical decision support systems

(2011) Jörn Kretschmer et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Increased blood glucose variability during therapeutic hypothermia and outcome after cardiac arrest*

(2011) Nadine Cueni-Villoz et al.   CRITICAL CARE MEDICINE

ICU capacity strain and the quality and allocation of critical care

(2011) Scott D. Halpern   Current Opinion in Critical Care

Evaluating Glycemic Control Algorithms by Computer Simulations

(2011) Malgorzata E. Wilinska et al.   Diabetes Technology & Therapeutics

Multi-scale lung modeling

(2011) Merryn H. Tawhai et al.   JOURNAL OF APPLIED PHYSIOLOGY

Failure to achieve euglycemia despite aggressive insulin control signals abnormal physiologic response to trauma

(2011) Nathan T. Mowery et al.   JOURNAL OF CRITICAL CARE

Characterisation of the iterative integral parameter identification method

(2011) Paul D. Docherty et al.   MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

The dynamic insulin sensitivity and secretion test—a novel measure of insulin sensitivity

(2011) Kirsten A. McAuley et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The cardiac physiome: Foundations and future prospects for mathematical modelling of the heart

(2011) Nic Smith et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

OpenCMISS: A multi-physics & multi-scale computational infrastructure for the VPH/Physiome project

(2011) Chris Bradley et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Physiological modeling, tight glycemic control, and the ICU clinician: what are models and how can they affect practice?

(2011) J Geoffrey Chase et al.   Annals of Intensive Care

Pilot proof of concept clinical trials of Stochastic Targeted (STAR) glycemic control

(2011) Alicia Evans et al.   Annals of Intensive Care

Human factors in the management of the critically ill patient

(2010) J.F. Bion et al.   BRITISH JOURNAL OF ANAESTHESIA

Development of a model-based clinical sepsis biomarker for critically ill patients

(2010) Jessica Lin et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Patient specific identification of the cardiac driver function in a cardiovascular system model

(2010) C.E. Hann et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Tight glycemic control in critical care – The leading role of insulin sensitivity and patient variability: A review and model-based analysis

(2010) J. Geoffrey Chase et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Impact of glucocorticoids on insulin resistance in the critically ill

(2010) Christopher Pretty et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

We should abandon randomized controlled trials in the intensive care unit

(2010) Jean-Louis Vincent   CRITICAL CARE MEDICINE

Using human factors engineering to improve the effectiveness of infection prevention and control

(2010) Judith Anderson et al.   CRITICAL CARE MEDICINE

Bedside assessment of mean systemic filling pressure

(2010) Jos RC Jansen et al.   Current Opinion in Critical Care

Image-based modeling of lung structure and function

(2010) Merryn H. Tawhai et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Customized In Silico Population Mimics Actual Population in Docetaxel Population Pharmacokinetic Analysis

(2010) Susan F. Hudachek et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Hypoglycemia and Outcome in Critically Ill Patients

(2010) Moritoki Egi et al.   MAYO CLINIC PROCEEDINGS

Metabolic and Clinical Effects of the Supplementation of a Functional Mixture of Amino Acids in Cerebral Hemorrhage

(2010) Alessandro Laviano et al.   Neurocritical Care

Cardiac cell modelling: Observations from the heart of the cardiac physiome project

(2010) Martin Fink et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Parameter Estimation and Model Selection in Computational Biology

(2010) Gabriele Lillacci et al.   PLoS Computational Biology

The Swan-Ganz Catheters: Past, Present, and Future

(2009) Kanu Chatterjee   CIRCULATION

A new library of HEMET model: Insulin effects on hepatic metabolism

(2009) A. Cutrone et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

A simulation model of insulin saturation and glucose balance for glycemic control in ICU patients

(2009) Ulrike Pielmeier et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Inotrope and Vasopressor Therapy of Septic Shock

(2009) Steven M. Hollenberg   CRITICAL CARE CLINICS

Multicenter, randomized, controlled trials evaluating mortality in intensive care: Doomed to fail?

(2009) Gustavo A. Ospina-Tascón et al.   CRITICAL CARE MEDICINE

Assessment of venous return curve and mean systemic filling pressure in postoperative cardiac surgery patients*

(2009) Jacinta J. Maas et al.   CRITICAL CARE MEDICINE

Can the costs of critical care be controlled?

(2009) Neil A Halpern   Current Opinion in Critical Care

Real-Time Continuous Glucose Monitoring in Critically Ill Patients: A prospective randomized trial

(2009) U. Holzinger et al.   DIABETES CARE

Comparison of Three Protocols for Tight Glycemic Control in Cardiac Surgery Patients

(2009) J. Blaha et al.   DIABETES CARE

The Glucosafe system for tight glycemic control in critical care: A pilot evaluation study

(2009) Ulrike Pielmeier et al.   JOURNAL OF CRITICAL CARE

Using a human cardiovascular-respiratory model to characterize cardiac tamponade and pulsus paradoxus

(2009) Deepa Ramachandran et al.   Theoretical Biology and Medical Modelling

Toward a VPH/Physiome ToolKit

(2009) Alan Garny et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Techniques for Assessment of Intravascular Volume in Critically Ill Patients

(2009) Paul E. Marik   JOURNAL OF INTENSIVE CARE MEDICINE

Guidelines Have Done More Harm than Good

(2008) Richard Amerling et al.   BLOOD PURIFICATION

Bioinformatics, multiscale modeling and the IUPS Physiome Project

(2008) P. J. Hunter et al.   BRIEFINGS IN BIOINFORMATICS

A replicable method for blood glucose control in critically Ill patients

(2008) Alan H. Morris et al.   CRITICAL CARE MEDICINE

The Cardiac Physiome: perspectives for the future

(2008) James Bassingthwaighte et al.   EXPERIMENTAL PHYSIOLOGY

Ability of dynamic airway pressure curve profile and elastance for positive end-expiratory pressure titration

(2008) Alysson R. Carvalho et al.   INTENSIVE CARE MEDICINE

Model-based identification and diagnosis of a porcine model of induced endotoxic shock with hemofiltration

(2008) C. Starfinger et al.   MATHEMATICAL BIOSCIENCES

A simulation model of glucose regulation in the critically ill

(2008) Roman Hovorka et al.   PHYSIOLOGICAL MEASUREMENT

Stochastic modelling of insulin sensitivity and adaptive glycemic control for critical care

(2007) Jessica Lin et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE