Article
Acoustics
Mark A. Kliewer, William B. Dyke, Christopher W. Birch, Anjuli R. Bagley
Summary: Patients with obstructive airway disease and volunteers subjected to increasing airway resistance exhibit greater fluctuations in peak systolic velocity (PSV) in carotid artery Doppler waveforms, which are significantly correlated with pulmonary function testing indices.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Medicine, General & Internal
Dilip Johny, Kodangala Subramanyam, Nandakishore Baikunje, Giridhar Belur Hosmane
Summary: COVID-19 can have various cardiac manifestations, such as cardiac tamponade, requiring emergency management and treatment. Prompt intervention and appropriate medications can lead to improvement in the patient's condition.
Article
Engineering, Electrical & Electronic
Tilendra Choudhary, L. N. Sharma, M. K. Bhuyan, Kangkana Bora
Summary: This paper proposes a SCG-based method for measuring breathing states, which evaluates the respiratory system by measuring chest-wall vibrations, extracts SCG cycles using orthogonal subspace projection, and identifies different respiratory effort levels using a stacked autoencoder. The proposed method shows good performance in recognizing three different breathing states.
IEEE SENSORS JOURNAL
(2021)
Review
Developmental Biology
Charlie J. Childs, Madeline K. Eiken, Jason R. Spence
Summary: This article discusses the current status of in vitro model systems, efforts to create large publicly available atlases of developing humans, and how these data are being used to improve organoids.
Article
Engineering, Biomedical
Xin Jin, Srinivas Laxminarayan, Sridevi Nagaraja, Anders Wallqvist, Jaques Reifman
Summary: Mathematical models of human cardiovascular and respiratory systems can be used to generate synthetic data for training AI clinical decision-support systems and evaluating closed-loop control technologies in military medical applications. The developed cardio-respiratory (CR) model successfully captures human physiological responses to battlefield trauma, with relatively small errors for vital signs such as mean arterial pressure and oxygen saturation.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2023)
Editorial Material
Genetics & Heredity
Xiyin Wang, Shannon M. Hawkins
Summary: The human endometrium exhibits complex signaling cascades mediated by spatial-temporal cellular interactions. Understanding the normal endometrial microenvironment is the first step towards understanding diseases of endometrial dysfunction.
Article
Medicine, General & Internal
Neil R. Kumar, Shreyans Patel, Bridget Norwood
Summary: This article presents a case of cardiac tamponade in a patient infected with COVID-19 without respiratory symptoms and reviews the literature on this rare complication. The patient improved with treatment using colchicine and steroids. It is important for healthcare providers to consider COVID-19 as a potential cause of cardiac tamponade, even in the absence of pulmonary disease.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Tim K. Tsang, Can Wang, Bingyi Yang, Simon Cauchemez, Benjamin J. Cowling
Summary: The severity of COVID-19 cases differs between index cases and secondary cases, with secondary cases less susceptible to ascertainment bias. By quantifying these differences, more accurate estimates of disease severity and missed cases can be obtained. Contact tracing of index cases provides more reliable data for estimating the severity of emerging infections.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Kwang-Eon Choi, Seongkwang Cha, Cheolmin Yun, Jungryul Ahn, Seil Hwang, Young-Jin Kim, Hachul Jung, Heejong Eom, Dongkwan Shin, Jaeryung Oh, Yong Sook Goo, Seong-Woo Kim
Summary: The objective of this study was to induce and evaluate drug-dose-dependent outer retinal degeneration in cynomolgus monkeys using N-methyl-N-nitrosourea (MNU). Intravitreal temporary tamponade with MNU solutions (2-3 mg ml(-1)) was performed after vitrectomy in five monkeys. Outer retinal degeneration, anatomical and functional changes were observed, especially in the peripheral retina. The findings suggest that temporary exposure to intravitreal MNU tamponade induces rod-dominant outer retinal degeneration, particularly in the peripheral retina.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Chengxi Yan, Ruili Li, Xiaojuan Guo, Huan Yu, Wenhuan Li, Wenqiao Li, Meiji Ren, Minglei Yang, Hongjun Li
Summary: In a Chinese HIV/AIDS cohort, HIV-infected patients showed changes in myocardial function and higher rates of subclinical myocardial inflammation and fibrosis. AIDS patients were more likely to develop myocardial fibrosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Yonatan R. Lewis-Israeli, Aaron H. Wasserman, Aitor Aguirre
Summary: Organoids are three-dimensional cell constructs that mimic organ properties and structure, and have been widely used to model various organs and disease conditions. However, the technology for generating and using heart organoids in cardiovascular research lags behind other organ types. Efforts are being made to overcome the challenges in creating heart organoids to advance cardiovascular studies and treatment of heart disorders.
Article
Biophysics
Vahid Ghodrati, Mark Bydder, Fadil Ali, Chang Gao, Ashley Prosper, Kim-Lien Nguyen, Peng Hu
Summary: The study demonstrated the potential of an adversarial autoencoder network for correcting respiratory motion-related image artifacts without requiring paired data.
NMR IN BIOMEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuan Chen, P. Hendrik Pretorius, Clifford Lindsay, Yongyi Yang, Michael A. King
Summary: A deep learning approach using SPECT projection data was developed to estimate respiratory signals, which reduces artifacts caused by respiratory motion and achieves similar regional quantification as using stereo-camera signals.
Article
Cardiac & Cardiovascular Systems
Brittany D. Brumback, Oleksandr Dmytrenko, Ashley N. Robinson, Adam L. Bailey, Pan Ma, Jing Liu, Stephanie C. Hicks, Sherwin Ng, Gang Li, David M. Zhang, Catherine E. Lipovsky, Chieh-Yu Lin, Michael S. Diamond, Kory J. Lavine, Stacey L. Rentschler
Summary: COVID-19 is associated with serious cardiovascular complications, and this study demonstrates that human cardiac pericytes are susceptible to SARS-CoV-2 infection. Viral entry into pericytes is mediated by endosomal proteases, leading to up-regulation of inflammatory markers and cell death. Evidence of cardiac pericyte infection was also found in COVID-19 myocarditis patients, suggesting a potential role for pericyte infection in COVID-19.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Construction & Building Technology
Xing Bi, Caiyan Wu, Yong Wang, Junxiang Li, Chunfang Wang, Amy Hahs, Suzanne Mavoa, Conghe Song, Charles Konrad, Michael Emch
Summary: As the climate warms, heatwaves are expected to increase in frequency, intensity, and duration. However, it is unclear if there are changes in human mortality from heatwaves over time. A study in Shanghai, China found that heatwaves were significantly associated with cause-specific mortality and total non-accidental diseases (TND) for different demographic subgroups during two periods from 2002 to 2004 and 2012-2014. The relative risks (RR) of mortality decreased for most subgroups over time, except for respiratory diseases (RD) which increased. The association between heatwave characteristics and mortality changed over time, with higher RRs for females, the elderly, and low-and middle-educated populations.
SUSTAINABLE CITIES AND SOCIETY
(2023)