Article
Mathematical & Computational Biology
Wen Zhang, Glen Laird, Josh Chen, Ying Yuan
Summary: This paper proposes a Bayesian phase II design for clinical trials with longitudinal measurement, such as pain management studies. The design utilizes a Bayesian hierarchical model to capture subject-specific trajectory and population trajectory, with a Bayesian penalized spline to model the shapes of these trajectories. The design takes a group sequential approach and considers both statistical significance and clinical relevance in making interim and final decisions.
STATISTICS IN MEDICINE
(2023)
Article
Biophysics
Atte Kekonen, Mikael Bergelin, Jan-Erik Eriksson, Annikki Vaalasti, Heimo Ylanen, Sami Kielosto, Jari Viik
Summary: The study developed a bioimpedance measurement-based method and system for evaluating wound healing status, demonstrating it as a promising quantitative tool for venous ulcers.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Medicine, General & Internal
Alexandre Lugat, Clement Bailly, Michel Cherel, Caroline Rousseau, Francoise Kraeber-Bodere, Caroline Bodet-Milin, Mickael Bourgeois
Summary: Radioimmunoconjugates have been widely used in nuclear medicine applications for over 30 years. Recent advances in cancer biology have led to the discovery of new molecular targets specific to certain patient subgroups, allowing for the development of specifically tailored therapeutic approaches. Immuno-positron emission tomography (immuno-PET) is a non-invasive imaging modality that utilizes monoclonal antibodies for in vivo characterization of tumor biomarkers, providing valuable information on tumor targeting. Immuno-PET shows great potential in various nuclear medicine applications, including staging/stratification, theranostic approaches, and predictive/prognostic biomarkers. Finding the right balance between isotope choice and immunologic structure is crucial for the development of radiopharmaceutical drugs for immuno-PET.
FRONTIERS IN MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Subhra Mandal, Shawnalyn W. Sunagawa, Pavan Kumar Prathipati, Michael Belshan, Annemarie Shibata, Christopher J. Destache
Summary: A targeted nanoformulation was designed to block CCR5 expression on T cells and inhibit HIV replication. The nanoformulation showed improved binding affinity to CCR5 and high binding affinity to different types of CCR5+ cells. Short-term prophylaxis study demonstrated that the nanoformulation induced a protective immune phenotype, which could contribute to achieving HIV functional cure.
Article
Psychology, Clinical
Kathryn I. Pollak, Jason A. Oliver, Carl Pieper, James M. Davis, Xiaomei Gao, Devon Noonan, Danielle Kennedy, Isa Granados, Laura J. Fish
Summary: The study demonstrated that a cue-based intervention is feasible and acceptable among light smokers, highlighting the need for a fully powered study to assess this approach.
ADDICTIVE BEHAVIORS
(2021)
Article
Mathematical & Computational Biology
Shiyang Ma, Michael P. McDermott
Summary: Adaptive designs in learning-phase clinical trials can be efficient and highly informative. This article extends the MCP-Mod procedure with GMCTs for two-stage adaptive designs for proof-of-concept. The results of an interim analysis guide adaptations to candidate dose-response models and dosages studied in the second stage, with GMCTs used in both stages to obtain and combine stage-wise p-values for an overall p-value. Simulation studies show advantages of adaptive designs over nonadaptive designs when candidate dose-response models are not well-informed by preclinical and early-phase evidence.
BIOMETRICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Mateo Glumac, Mirjana Polovic, Anja Batel, Andrea Gelemanovic, Boris Macek, Ana Velic, Ivana Marinovic-Terzic
Summary: DNA-protein crosslinks (DPCs) are toxic lesions that interfere with DNA processing and transcription. The development of an accurate biochemical assay for DPC isolation is crucial for understanding their repair process. The STAR assay is proposed for direct quantification of DPCs under physiologically relevant conditions. Implementation of the STAR assay revealed the presence of small cross-linked peptides on DNA, created by proteolytic degradation of DPCs by SPRTN. This degradation is required for downstream activation of DNA repair and subsequent removal of the cross-linked peptides.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Teodolinda Di Risi, Mariella Cuomo, Roberta Vinciguerra, Sara Ferraro, Rosa Della Monica, Davide Costabile, Michela Buonaiuto, Federica Trio, Ettore Capoluongo, Roberta Visconti, Eleonora Riccio, Antonio Pisani, Lorenzo Chiariotti
Summary: This study analyzed the genome-wide methylation profile of patients with Fabry disease for the first time. Although the whole methylome profile did not differentiate between FD patients and unaffected individuals, several genes showed significant differential methylation in Fabry patients. This finding may contribute to the identification of Fabry patients and the prediction of disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Sridharan Raghavan, Kevin Josey, Gideon Bahn, Domenic Reda, Sanjay Basu, Seth A. Berkowitz, Nicholas Emanuele, Peter Reaven, Debashis Ghosh
Summary: The generalizability of heterogeneous treatment effects (HTE) derived from machine learning in different study samples is uncertain. In this study, the authors examined the generalizability of HTE detected using causal forests in two randomized trials in type II diabetes patients. They found that while the variable importance was correlated between the two trials, the HTE did not replicate in similar subgroups, suggesting limited generalizability.
ANNALS OF EPIDEMIOLOGY
(2022)
Article
Management
Juliana Keiko Sagawa, Allan Freitas Oliveira, Gasper Music, Martin J. Land, Arthur Sarro Maluf
Summary: Workload control relies on order release and capacity adjustments to regulate manufacturing throughput. Integrated input-output control is rarely studied. A closed-loop integrated model with automatic feedback control is proposed, where order release and capacity decisions are continuous functions of the shop floor state. The model was tested in scenarios of unbalanced work in process and demand fluctuations, showing effective control and cost-saving capacity policies. The proposed approach combines the strengths of closed-loop control models and discrete-event simulation models. Rating: 9/10
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Laurent Dercle, Melissa Yang, Mithat Gonen, Jessica Flynn, Chaya S. Moskowitz, Dana E. Connors, Hao Yang, Lin Lu, Diane Reidy-Lagunes, Tito Fojo, Sanja Karovic, Binsheng Zhao, Lawrence H. Schwartz, Brian S. Henick
Summary: This study assessed the association between ethnicity and efficacy by using quantitative analysis of computed tomography (CT) scans of metastatic colorectal cancer (mCRC) patients. The results showed significant differences in treatment response, tumor volume change, and tumor imaging features among different ethnicities. The study highlights the impact of inadequate representation of minority groups in clinical trials on associated translational work.
EUROPEAN RADIOLOGY
(2023)
Article
Computer Science, Information Systems
Wanwan Xu, Chang Su, Yan Li, Steven Rogers, Fei Wang, Kun Chen, Robert Aseltine
Summary: To reduce suicidal behavior among patients in the healthcare system, accurate and explainable predictive models of suicide risk are required. A general targeted fusion learning framework was proposed to build tailored risk prediction models for specific healthcare settings, using information fusion from a more comprehensive dataset. Results suggest that performance of predictive models in specific target settings can be improved without complete integration of raw records from external data sources.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2022)
Review
Medicine, General & Internal
Jaakko Tuomilehto, Matti Uusitupa, Edward W. W. Gregg, Jaana Lindstrom
Summary: Several randomized controlled trials have demonstrated the effectiveness of lifestyle interventions in preventing type 2 diabetes (T2D) in high-risk individuals. The national T2D prevention plan in Finland, implemented in 2000, has successfully decreased the incidence of drug-treated T2D. The United States has also authorized a national diabetes prevention program (NDPP) that relies on primary care referrals and self-referrals.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Anna Fiorillo, Vincenzo Fogliano, Mauro Marra, Lorenzo Camoni
Summary: By treating potato plants with elicitors of plant defense responses, it was found that the starch availability and digestibility in tubers could be reduced through inducing cell wall remodeling and stiffening. This highlights the potential for new agronomic practices to produce low GI index potatoes.
Article
Dentistry, Oral Surgery & Medicine
Erni Marlina, Richard N. Goodman, Valeria Mercadante, Martina Shephard, Roddy McMillan, Tim Hodgson, Rachel Leeson, Stephen Porter, Julie A. Barber, Stefano Fedele, Andrew M. Smith
Summary: This study evaluated the clinical effects of probiotic VSL#3 in individuals with symptomatic oral lichen planus. The results showed that VSL#3 was safe and well tolerated, but did not demonstrate significant changes in pain, disease activity, quality of life, serum/salivary CXCL10, or oral microbial composition compared to placebo. Further research is needed to confirm these preliminary findings.
Article
Mathematical & Computational Biology
Noorsyazwani Binti Zulkifli, Fatanah M. Suhaimi, Ng Siew Cheok, Khin Wee Lai
JOURNAL OF MEDICAL IMAGING AND HEALTH INFORMATICS
(2019)
Review
Engineering, Biomedical
Syatirah Mat Zin, S. Z. Md Rasib, Fatanah M. Suhaimi, M. Mariatti
Summary: EPG, also known as electropalatography, is a device used in speech therapy to identify tongue and hard palate contact locations. It is particularly helpful for patients with conditions like cleft palate, Down syndrome, glossectomy, and autism. Continuous development of EPG technology based on patient needs and treatment advancements makes it a valuable medical device in speech therapy.
BIOMEDICAL ENGINEERING ONLINE
(2021)
Article
Anesthesiology
Nur Jihan Mohd Zukhi, Mohd Zulfakar Mazlan, Fatanah Mohamad Suhaimi
Summary: Diabetic ketoacidosis (DKA) is a life-threatening complication of diabetes mellitus (DM) that can lead to high mortality. Patients with stroke and DKA have an increased incidence and mortality rate in the intensive care unit (ICU).
ANAESTHESIA PAIN & INTENSIVE CARE
(2022)
Article
Engineering, Multidisciplinary
Jihan Zukhi, Fatanah M. Suhaimi, Mohd Zulfakar Mazlan, Mastura Mohd Sopian, Nizuwan Azman, Ummu K. Jamaludin, Normy Razak
Summary: This study found that diabetic patients have higher insulin sensitivity and better glycemic control compared to non-diabetic patients. There are significant differences in insulin sensitivity and glycemic control between different patient groups, indicating that successful glycemic control is influenced by factors such as insulin sensitivity, diabetes status, and patient condition.
INTERNATIONAL JOURNAL OF INTEGRATED ENGINEERING
(2021)
Proceedings Paper
Engineering, Biomedical
Fatanah M. Suhaimi, Syatirah Mat Zin, Seniz Ertugrul, Mohd Zulfakar Mazlan, Nur Jihan M. Zukhi
Summary: Type II diabetes mellitus is a common and severe chronic disease affecting populations globally, with its complications posing a significant public health issue. Research suggests that different patients may require categorization based on their specific model structures and time delays to accurately describe their glucose-insulin interaction.
2020 IEEE-EMBS CONFERENCE ON BIOMEDICAL ENGINEERING AND SCIENCES (IECBES 2020): LEADING MODERN HEALTHCARE TECHNOLOGY ENHANCING WELLNESS
(2021)
Proceedings Paper
Engineering, Biomedical
Jihan Zukhi, Fatanah M. Suhaimi, Mohd Zulfakar Mazlan, Ummu K. Jamaludin, Normy Razak, Nizuwan Azman
Summary: The study compared the performance of two sliding scale-based glycemic control protocols on different cohorts, finding that cohort A had more dynamic metabolism and lower insulin sensitivity. Both protocols showed no significant difference in blood glucose levels, but the APACHE II scores indicated more severe conditions in cohort A.
2020 IEEE-EMBS CONFERENCE ON BIOMEDICAL ENGINEERING AND SCIENCES (IECBES 2020): LEADING MODERN HEALTHCARE TECHNOLOGY ENHANCING WELLNESS
(2021)
Proceedings Paper
Automation & Control Systems
Syatirah Mat Zin, Fatanah M. Suhaimi, Nur Fatehah Md Shakur, Siti Noor Fazliah Mohd Noor, AhmadFakrurrozi Mohamad, Nurulakma Zali
Proceedings Paper
Automation & Control Systems
Jihan Zukhi, Fatanah M. Suhaimi, Mohd Zulfakar Mazlan, Ummu K. Jamaludin, Normy Razak, Mastura Mohd Sopian
Article
Engineering, Multidisciplinary
Fatanah M. Suhaimi, Nurul Atiqah A. Razak, Nur Syazana Azizan, Mohd Aizat Abu Bakar, Mohammad Khairul Azhar Abdul Razab, Norehan Mokhtar, Nizuwan Azman
JURNAL TEKNOLOGI-SCIENCES & ENGINEERING
(2020)
Proceedings Paper
Neuroimaging
J. A. Rabba, H. A. Jaafar, M. Z. M. Jafri, F. M. Suhaimi, N. D. Osman
11TH INTERNATIONAL SEMINAR ON MEDICAL PHYSICS (ISMP) 2019
(2020)
Article
Engineering, Biomedical
Athirah Abdul Razak, Asma Abu-Samah, Normy Norfiza Abdul Razak, Ummu Jamaludin, Fatanah Suhaimi, Azrina Ralib, Mohd Basri Mat Nor, Christopher Pretty, Jennifer Laura Knopp, James Geoffrey Chase
MEDICAL DEVICES-EVIDENCE AND RESEARCH
(2020)
Article
Engineering, Multidisciplinary
Syatirah Mat Zin, Fatanah M. Suhaimi, Nur Fatehah Md Shakur, Siti Noor Fazliah Mohd Noor, Ahmad Fakrul Mohamad, Nurulakma Zali
INTERNATIONAL JOURNAL OF INTEGRATED ENGINEERING
(2019)
Article
Engineering, Biomedical
Asma Abu-Samah, Jennifer Launa Knopp, Normy Norfiza Abdul Razak, Athirah Abdul Razak, Ummu Kulthum Jamaludin, Fatanah Mohamad Suhaimi, Azrina Md Ralib, Mohd Basri Mat Nor, James Geoffrey Chase, Christopher Grant Pretty
MEDICAL DEVICES-EVIDENCE AND RESEARCH
(2019)
Article
Engineering, Multidisciplinary
Asma Abu-Samah, Normy Norfiza Abdul Razak, Fatanah Mohamad Suhaimi, Ummu Kulthum Jamaludin, Azrina Md Ralib
Proceedings Paper
Engineering, Biomedical
Siti Fatimah Samsurrijal, Fatanah M. Suhaimi, Siti Noor Fazliah Mohd Noor, Syatirah Mat Zin
2018 IEEE-EMBS CONFERENCE ON BIOMEDICAL ENGINEERING AND SCIENCES (IECBES)
(2018)