Article
Medicine, General & Internal
Candelaria de Haro, Ary Serpa Neto, Gemma Goma, Maria Elena Gonzalez, Alfonso Ortega, Catalina Forteza, Fernando Frutos-Vivar, Raquel Garcia, Fabienne D. Simonis, Federico Gordo-Vidal, David Suarez, Marcus J. Schultz, Antonio Artigas
Summary: This study aimed to compare the effects of low tidal volume strategy and intermediate tidal volume strategy on preventing lung complications in patients at risk of ARDS. A total of 98 patients were enrolled in the study, and the results showed no significant differences between low tidal volume strategy and intermediate tidal volume strategy in terms of incidence of ARDS, pneumonia and severe atelectasis, length of ICU and hospital stay, and 28-day and 90-day mortality rates.
FRONTIERS IN MEDICINE
(2023)
Article
Critical Care Medicine
Sadeq A. Quraishi, Ishir Bhan, Michael A. Matthay, Boyd T. Thompson, Carlos A. Camargo, Ednan K. Bajwa
Summary: The study found that in ARDS patients, vitamin D levels are associated with duration of mechanical ventilation and 90-day mortality. Patients with lower 25OHD levels had longer ventilation time and higher risk of mortality. Randomized, controlled trials are needed to determine if vitamin D supplementation can improve clinical outcomes in ARDS patients.
JOURNAL OF INTENSIVE CARE MEDICINE
(2022)
Article
Critical Care Medicine
Sara Pitoni, Sonia D'Arrigo, Domenico Luca Grieco, Francesco Antonio Idone, Maria Teresa Santantonio, Pierluigi Di Giannatale, Alessandro Ferrieri, Daniele Natalini, Davide Eleuteri, Bjorn Jonson, Massimo Antonelli, Salvatore Maurizio Maggiore
Summary: In brain-injured patients with ARDS, replacing heat and moisture exchangers with heated humidifiers allows for safe reduction in tidal volume, plateau pressure, and driving pressure without affecting carbon dioxide clearance and oxygenation.
NEUROCRITICAL CARE
(2021)
Article
Emergency Medicine
Michael Self, Christie Mun, Andrew Goodrich, Ulrich Schmidt
Summary: The study aimed to create a simplified equation to predict low-tidal-volume ventilation (LTVV) based on height. The equation successfully predicted a tidal volume of 6-8 mL/kg ideal body weight in a cohort of patients with a height of ≥ 60 inches.
JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Rainer Thomas, Tanghua Liu, Arno Schad, Robert Ruemmler, Jens Kamuf, Rene Rissel, Thomas Ott, Matthias David, Erik K. Hartmann, Alexander Ziebart
Summary: In a porcine model of septic shock and ARDS, the serum hyaluronic acid levels were significantly elevated in both sepsis groups compared to the no-LPS-group. Intergroup comparison between lung protective ventilated and high tidal ventilated animals revealed no significant differences in the serum hyaluronic acid levels.
Article
Critical Care Medicine
Shannon M. Fernando, Eddy Fan, Bram Rochwerg, Karen E. A. Burns, Laurent J. Brochard, Deborah J. Cook, Allan J. Walkey, Niall D. Ferguson, Catherine L. Hough, Daniel Brodie, Andrew J. E. Seely, Venkatesh Thiruganasambandamoorthy, Jeffrey J. Perry, Alexandre Tran, Peter Tanuseputro, Kwadwo Kyeremanteng
Summary: The study showed that the use of lung-protective ventilation in the emergency department can lead to lower hospital mortality, decreased incidence of ARDS, shorter mechanical ventilation and hospital stay durations, and reduced total hospital costs for invasively ventilated patients.
Article
Critical Care Medicine
Scott J. Millington, Pierre Cardinal, Laurent Brochard
Summary: Although maintaining positive end-expiratory pressure (PEEP) is necessary for ARDS patients, selecting and titrating a specific level remains challenging. The popular open lung approach has biological plausibility but carries risks, and there is a lack of evidence-based guidance for initial PEEP settings. We propose a practical approach based on simple measurements to achieve a balance between the risks and benefits of PEEP.
Article
Engineering, Biomedical
Karel Roubik, Jakub Rafl, Martin Rozanek, Petr Kudrna, Mikulas Mlcek
Summary: The coupling between oxygenation and carbon dioxide elimination is different between conventional mechanical ventilation (CV) and high-frequency oscillatory ventilation (HFOV), with changes in tidal volume affecting oxygenation more significantly during HFOV.
BIOMEDICAL ENGINEERING ONLINE
(2022)
Article
Critical Care Medicine
Jose Dianti, John Matelski, Manuel Tisminetzky, Allan J. Walkey, Laveena Munshi, Lorenzo Del Sorbo, Eddy Fan, Eduardo L. Costa, Carol L. Hodgson, Laurent Brochard, Ewan C. Goligher
Summary: In trials of lung-protective ventilation strategies, tidal volume, driving pressure, mechanical power all exhibit similar effects on mortality.
Article
Critical Care Medicine
V. Marco Ranieri, Tommaso Tonetti, Paolo Navalesi, Stefano Nava, Massimo Antonelli, Antonio Pesenti, Giacomo Grasselli, Domenico Luca Grieco, Luca Salvatore Menga, Lara Pisani, Annalisa Boscolo, Nicolo Sella, Laura Pasin, Chiara Mega, Giacinto Pizzilli, Alessio Dell'Olio, Roberto Dongilli, Paola Rucci, Arthur S. Slutsky
Summary: Broadening the definition of ARDS to include patients on HFNO with Pa-O2/FIO2 <= 300 may help identify patients in the early stages of the disease with lower mortality rates.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Katja Mohnke, Victoria Buschmann, Thomas Baller, Julian Riedel, Miriam Renz, Rene Rissel, Alexander Ziebart, Erik K. K. Hartmann, Robert Ruemmler
Summary: This porcine study aimed to validate the hypothesis that ultra-low tidal volume ventilation during CPR minimizes renal and hepatic end-organ damage compared to standard intermittent positive pressure ventilation. The study found that ULTVV may be advantageous over standard ventilation in the short-term ROSC follow-up period.
Review
Critical Care Medicine
Karlee De Monnin, Emily Terian, Lauren H. Yaegar, Ryan D. Pappal, Nicholas M. Mohr, Brian W. Roberts, Marin H. Kollef, Christopher M. Palmer, Enyo Ablordeppey, Brian M. Fuller
Summary: Low tidal volume ventilation (LTVV) initiated in the emergency department (ED) has positive effects on outcomes and ventilator settings. This systematic review and meta-analysis provide quantitative evidence of the impact of ED-based LTVV on outcomes and ventilator settings in the ED and ICU.
CRITICAL CARE MEDICINE
(2022)
Correction
Critical Care Medicine
Mathieu Blot, Marine Jacquier, Ludwig-Serge Aho Glele, Guillaume Beltramo, Maxime Nguyen, Philippe Bonniaud, Sebastien Prin, Pascal Andreu, Belaid Bouhemad, Jean-Baptiste Bour, Christine Binquet, Lionel Piroth, Jean-Paul Pais de Barros, David Masson, Jean-Pierre Quenot, Pierre-Emmanuel Charles
Summary: An amendment to this paper has been published and is accessible through the original article.
Article
Critical Care Medicine
Jose Dianti, Arthur S. Slutsky, Ewan C. Goligher
Summary: The estimated ratio of dead space to tidal volume and the measured ratio showed low levels of agreement and cannot be used interchangeably. However, the predicted decrease in driving pressure due to extracorporeal CO2 removal was similar when computed from either estimated or measured data.
Article
Multidisciplinary Sciences
Robert A. Raschke, Brenda Stoffer, Seth Assar, Stephanie Fountain, Kurt Olsen, C. William Heise, Tyler Gallo, Angela Padilla-Jones, Richard Gerkin, Sairam Parthasarathy, Steven C. Curry
Summary: The study found that driving pressures >= 19 cmH(2)O were associated with increased mortality, while the use of TV/PBW 4-6ml/kg in less than 15% of patients was associated with increased mortality compared to TV/PBW 6-10 ml/kg used in 82% of patients.
Letter
Critical Care Medicine
Maria Cruz Soriano, Gabriela Narvaez-Chavez, Marina Lopez-Olivencia, Jesus Fortun, Raul de Pablo
INTENSIVE CARE MEDICINE
(2022)
Letter
Critical Care Medicine
Adrian Ceccato, Raquel Perez-Arnal, Anna Motos, Ferran Barbe, Antoni Torres
INTENSIVE CARE MEDICINE
(2022)
Article
Microbiology
Tamara Caniego-Casas, Laura Martinez-Garcia, Marina Alonso-Riano, David Pizarro, Irene Carretero-Barrio, Nilda Martinez-de-Castro, Ignacio Ruz-Caracuel, Raul de Pablo, Ana Saiz, Rosa Nieto Royo, Ana Santiago, Marta Rosas, Jose L. Rodriguez-Peralto, Belen Perez-Mies, Juan C. Galan, Jose Palacios
Summary: This study investigated the presence of SARS-CoV-2 in autopsy samples of COVID-19 patients and its association with secondary pulmonary infections. The findings showed that viral RNA was detected in the lungs of most patients, even those with longer disease duration. Viral protein and RNA were also detected in patients with shorter illness duration, indicating the persistence of the virus in the body. Additionally, various pulmonary infections were found to contribute to the severity of COVID-19.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Ana Elena Perez-Cobas, Fernando Baquero, Raul de Pablo, Maria Cruz Soriano, Teresa M. Coque
Summary: Nosocomial pneumonia is a common infection in critical patients, primarily associated with mechanical ventilation. The rise in multidrug-resistant bacterial infections has increased mortality rates, posing a global public health threat. Recent research suggests that a healthy respiratory tract microbiome (RTM) stimulates the immune system and protects against pathogen infection. However, the physiological conditions and interventions in critical patients disrupt the RTM, leading to dysbiosis. The significance of host-RTM interactions in nosocomial infections remains mostly unknown.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Luigi Pisani, Anna Geke Algera, Ary Serpa Neto, Luciano Azevedo, Tai Pham, Frederique Paulus, Marcelo Gama de Abreu, Paolo Pelosi, Arjen M. Dondorp, Giacomo Bellani, John G. Laffey, Marcus J. Schultz
Summary: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in middle income countries (MICs) than in high-income countries (HICs), with a strong association with country-level economic status.
LANCET GLOBAL HEALTH
(2022)
Article
Critical Care Medicine
Manoj Maddali, Matthew Churpek, Tai Pham, Emanuele Rezoagli, Hanjing Zhuo, Wendi Zhao, June He, Kevin L. Delucchi, Chunxue Wang, Nancy Wickersham, J. Brennan McNeil, Alejandra Jauregui, Serena Ke, Kathryn Vessel, Antonio Gomez, Carolyn M. Hendrickson, Kirsten N. Kangelaris, Aartik Sarma, Aleksandra Leligdowicz, Kathleen D. Liu, Michael A. Matthay, Lorraine B. Ware, John G. Laffey, Giacomo Bellani, Carolyn S. Calfee, Pratik Sinha
Summary: Clinical classifier models based on machine learning can accurately assign ARDS subphenotypes, providing valuable prognostic information for patients and potentially guiding personalized treatment strategies in clinical practice.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Critical Care Medicine
Tomas F. Farina-Gonzalez, Antonio Nunez-Reiz, Viktor Yordanov-Zlatkov, Julieta Latorre, Maria Calle-Romero, Patricia Alonso-Martinez, Sara Domingo-Marin, Miguel Sanchez-Garcia
Summary: This study analyzed the characteristics and time course of lung mechanics and gas exchange in COVID-19-related ARDS patients during the first 10 days of mechanical ventilation. The results showed that age and the need for renal replacement therapies were associated with higher mortality. After 96 to 120 hours from mechanical ventilation initiation, respiratory variables significantly diverged between survivors and non-survivors.
JOURNAL OF INTENSIVE CARE MEDICINE
(2022)
Article
Microbiology
Alexey Ruzin, Olivier Barraud, Li Yu, Bruno Francois, Miguel Sanchez-Garcia, Philippe Eggimann, Pierre-Francois Dequin, Pierre-Francois Laterre, Vincent Huberlant, Lucia Vina, Thierry Boulain, Cedric Bretonniere, Jerome Pugin, Jose Trenado, Ana Catalina Hernandez Padilla, Julie Vignaud, Drieke Vandamme, Herman Goossens, Christine Lammens, S. Omar Ali, Kathryn Shoemaker, Pin Ren, Susan Colbert, Terramika Bellamy, Bret R. Sellman, Michael McCarthy, Hasan S. Jafri, Mark T. Esser
Summary: We investigated the performance of Xpert MRSA/S. aureus SSTI qPCR assay for reducing the incidence of S. aureus pneumonia. The study found that the qPCR assay was more sensitive than conventional culture method and its output correlated with the efficacy of suvratoxumab in reducing pneumonia incidence or death in mechanically ventilated patients colonized with S. aureus.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Respiratory System
Jessica Gonzalez, Jordi de Batlle, Ivan D. Benitez, Gerard Torres, Sally Santisteve, Adriano D. S. Targa, Clara Gort-Paniello, Anna Moncusi-Moix, Maria Aguila, Fatty Seck, Adrian Ceccato, Ricard Ferrer, Anna Motos, Jordi Riera, Laia Fernandez, Rosario Menendez, Jose Angel Lorente, Oscar Penuelas, Dario Garcia-Gasulla, Yhivian Penasco, Pilar Ricart, Elena Abril Palomares, Luciano Aguilera, Alejandro Rodriguez, Maria Victoria Boado Varela, Belen Betere, Juan Carlos Pozo-Laderas, Jordi Sole-Violan, Inmaculada Salvador-Adell, Mariana Andrea Novo, Jose Barberan, Rosario Amaya Villar, Jose Garnacho-Montero, Jose M. Gomez, Aaron Blandino Ortiz, Luis Tamayo Lomas, Alejandro Ubeda, Mercedes Catalan-Gonzalez, Angel Sanchez-Miralles, Ignacio Martinez Varela, Ruth Noemi Jorge Garcia, Nieves Franco, Victor D. Gumucio-Sanguino, Elena Bustamante-Munguira, Luis Jorge Valdivia, Jesus Caballero, Elena Gallego, Covadonga Rodriguez, Alvaro Castellanos-Ortega, Josep Trenado, Judith Marin-Corral, Guillermo M. Albaiceta, Maria del Carmen de la Torre, Ana Loza-Vazquez, Pablo Vidal, Jose M. Anon, Cristina Carbajales Perez, Victor Sagredo, Nieves Carbonell, Lorenzo Socias, Carme Barbera, Angel Estella, Emili Diaz, David de Gonzalo-Calvo, Antoni Torres, Ferran Barbe
Summary: A study found that critical COVID-19 survivors are at high risk of impaired lung function and CT scan abnormalities during follow-up. Key factors associated with DLCO < 60% include chronic lung disease, duration of invasive mechanical ventilation, age, urea, and estimated glomerular filtration rate. Factors associated with fibrotic lesions include bacterial pneumonia and duration of ventilation. Age and chronic lung disease are important factors associated with impaired lung function and CT abnormalities in critical COVID-19 patients.
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Letter
Infectious Diseases
Catia Cilloniz, Anna Motos, Tatiana Castaneda, Albert Gabarrus, Ferran Barbe, Antoni Torres
JOURNAL OF INFECTION
(2023)
Editorial Material
Critical Care Medicine
R. de Pablo, A. Blandino Ortiz
MEDICINA INTENSIVA
(2023)
Article
Critical Care Medicine
Roberto Lorusso, Maria Elena De Piero, Silvia Mariani, Michele Di Mauro, Thierry Folliguet, Fabio Silvio Taccone, Luigi Camporota, Justyna Swol, Dominik Wiedemann, Mirko Belliato, Lars Mikael Broman, Alain Vuylsteke, Yigal Kassif, Anna Mara Scandroglio, Vito Fanelli, Philippe Gaudard, Stephane Ledot, Julian Barker, Udo Boeken, Sven Maier, Alexander Kersten, Bart Meyns, Matteo Pozzi, Finn M. Pedersen, Peter Schellongowski, Kaan Kirali, Nicholas Barrett, Jordi Riera, Thomas Mueller, Jan Belohlavek, EuroECMO COVID Study Grp
Summary: This study aimed to investigate in-hospital outcomes in patients who received ECMO during the first wave of COVID-19 and found that factors such as patient's age, timing of cannulation, and use of medication were associated with higher in-hospital mortality. Despite favorable post-discharge survival, some patients still require long-term rehabilitation.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Critical Care Medicine
Tai Pham, Leo Heunks, Giacomo Bellani, Fabiana Madotto, Irene Aragao, Gaetan Beduneau, Ewan C. Goligher, Giacomo Grasselli, Jon Henrik Laake, Jordi Mancebo, Oscar Penuelas, Lise Piquilloud, Antonio Pesenti, Hannah Wunsch, Frank van Haren, Laurent Brochard, John G. Laffey
Summary: This study investigated the management and outcomes of weaning from invasive mechanical ventilation in patients requiring at least 2 days of ventilation. The results showed that only 65% of patients were successfully weaned at 90 days. Factors such as delayed initiation of weaning and excessive sedation levels were associated with weaning failure. Understanding these factors could improve the success rate of weaning.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Infectious Diseases
Juan Antonio Castillo-Polo, Marta Hernandez-Garcia, Maria Isabel Morosini, Blanca Perez-Viso, Cruz Soriano, Raul De Pablo, Rafael Canton, Patricia Ruiz-Garbajosa
Summary: The study aimed to describe the phenotypic and genotypic characteristics of ceftazidime/avibactam- and cefiderocol-resistant KPC-Klebsiella pneumoniae (KPC-Kp) during an outbreak in a medical ICU. The KPC-Kp isolates involved in the outbreak were found to belong to the high-risk clone ST307 and carried the KPC + CTX-M-15 genes. Cloning experiments showed that specific gene mutations may contribute to resistance to ceftazidime/avibactam and cefiderocol.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Critical Care Medicine
Francisco Alvarez-Lerma, Mercedes Catalan-Gonzalez, Joaquin Alvarez, Miguel Sanchez-Garcia, Mercedes Palomar-Martinez, Inmaculada Fernandez-Moreno, Jose Garnacho-Montero, Fernando Barcenilla-Gaite, Rosa Garcia, Jesus Aranaz-Andres, Francisco J. Lozano-Garcia, Paula Ramirez-Galleymore, Montserrat Martinez-Alonso
Summary: This study assessed the impact of a multimodal interventional project (Zero Resistance) on the acquisition of multidrug-resistant bacteria (MDR-B) during the patient's ICU stay. The results showed a reduction in the rate of patients acquiring MDR-B after the implementation of the intervention.
MEDICINA INTENSIVA
(2023)