Evaluation of the Cardiotoxicity of Mitragynine and Its Analogues Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity

(2013) Ping Liang et al.   CIRCULATION

Induced Pluripotent Stem Cells in Cardiovascular Drug Discovery

(2013) Mark Mercola et al.   CIRCULATION RESEARCH

Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome

(2013) Milena Bellin et al.   EMBO JOURNAL

Mitragyna speciosa use in the northern states of Malaysia: A cross-sectional study

(2012) Kamarudin Ahmad et al.   JOURNAL OF ETHNOPHARMACOLOGY

A Drug Fatality Involving Kratom

(2012) Michael F. Neerman et al.   JOURNAL OF FORENSIC SCIENCES

Hydrogen Sulfide Suppresses Outward Rectifier Potassium Currents in Human Pluripotent Stem Cell-Derived Cardiomyocytes

(2012) Heming Wei et al.   PLoS One

Pharmacological response of human cardiomyocytes derived from virus-free induced pluripotent stem cells

(2011) Ashish Mehta et al.   CARDIOVASCULAR RESEARCH

A Drug Toxicity Death Involving Propylhexedrine and Mitragynine*

(2011) Justin M. Holler et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Unintentional Fatal Intoxications with Mitragynine and O-Desmethyltramadol from the Herbal Blend Krypton

(2011) R. Kronstrand et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Mitragynine inhibits the COX-2 mRNA expression and prostaglandin E2 production induced by lipopolysaccharide in RAW264.7 macrophage cells

(2011) Zulkhurnain Utar et al.   JOURNAL OF ETHNOPHARMACOLOGY

Evaluation of the Effects of Mitragyna speciosa Alkaloid Extract on Cytochrome P450 Enzymes Using a High Throughput Assay

(2011) Wai Mun Kong et al.   MOLECULES

Modelling the long QT syndrome with induced pluripotent stem cells

(2011) Ilanit Itzhaki et al.   NATURE

Monitoring of kratom or Krypton intake in urine using GC-MS in clinical and forensic toxicology

(2010) Anika A. Philipp et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Kratom alkaloids and O-desmethyltramadol in urine of a “Krypton” herbal mixture consumer

(2010) Torsten Arndt et al.   FORENSIC SCIENCE INTERNATIONAL

Acute toxicity study of the standardized methanolic extract of Mitragyna speciosa Korth in Rodent

(2010) S.N. Harizal et al.   JOURNAL OF ETHNOPHARMACOLOGY

Phase I and II metabolites of speciogynine, a diastereomer of the main Kratom alkaloid mitragynine, identified in rat and human urine by liquid chromatography coupled to low- and high-resolution linear ion trap mass spectrometry

(2010) Anika A. Philipp et al.   JOURNAL OF MASS SPECTROMETRY

SYMPOSIUM REVIEW: Revealing the structural basis of action of hERG potassium channel activators and blockers

(2010) Matthew Perry et al.   JOURNAL OF PHYSIOLOGY-LONDON

In Vitro and in Vivo Effects of Three Different Mitragyna speciosa Korth Leaf Extracts on Phase II Drug Metabolizing Enzymes—Glutathione Transferases (GSTs)

(2010) Juzaili Azizi et al.   MOLECULES

Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression

(2010) N. Farah Idayu et al.   PHYTOMEDICINE

Droperidol and Ondansetron-induced QT Interval Prolongation

(2009) Beny Charbit et al.   ANESTHESIOLOGY

Determination of mitragynine in rat plasma by LC–MS/MS: Application to pharmacokinetics

(2009) Natália Valadares de Moraes et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Evaluation of Antioxidant and Antibacterial Activities of Aqueous, Methanolic and Alkaloid Extracts from Mitragyna Speciosa (Rubiaceae Family) Leaves

(2009) Suhanya Parthasarathy et al.   MOLECULES

Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth)

(2008) Edward W. Boyer et al.   ADDICTION

In Vitro Electrophysiological Drug Testing Using Human Embryonic Stem Cell Derived Cardiomyocytes

(2008) Oren Caspi et al.   STEM CELLS AND DEVELOPMENT