A Review of the Evidence that Ochratoxin A Is an Nrf2 Inhibitor: Implications for Nephrotoxicity and Renal Carcinogenicity

Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells — up regulation of Nrf2 expression and down regulation of NF-κB and COX-2

(2013) Periasamy Ramyaa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Identification of aldo-keto reductases as NRF2-target marker genes in human cells

(2013) Kyeong-Ah Jung et al.   TOXICOLOGY LETTERS

Toxicity of Ochratoxin A and Its Modulation by Antioxidants: A Review

(2013) Valeria Sorrenti et al.   Toxins

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells

(2012) Alice Limonciel et al.   ARCHIVES OF TOXICOLOGY

An overview of transcriptional regulation in response to toxicological insult

(2012) Paul Jennings et al.   ARCHIVES OF TOXICOLOGY

Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress

(2012) Anja Wilmes et al.   Journal of Proteomics

Glucose reintroduction triggers the activation of Nrf2 during experimental ischemia reperfusion

(2012) Daniel Crean et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cross-talk between microRNAs, nuclear factor E2-related factor 2, and heme oxygenase-1 in ochratoxin A-induced toxic effects in renal proximal tubular epithelial cells

(2012) Anna Stachurska et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Topical Application of Ochratoxin A Causes DNA Damage and Tumor Initiation in Mouse Skin

(2012) Rahul Kumar et al.   PLoS One

Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model

(2011) Paul Jennings et al.   ARCHIVES OF TOXICOLOGY

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

An Update on Direct Genotoxicity as a Molecular Mechanism of Ochratoxin A Carcinogenicity

(2011) Annie Pfohl-Leszkowicz et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Perturbation of Mitosis through Inhibition of Histone Acetyltransferases: The Key to Ochratoxin A Toxicity and Carcinogenicity?

(2011) Kristin Czakai et al.   TOXICOLOGICAL SCIENCES

Transcriptional Regulation of Renal Cytoprotective Genes by Nrf2 and Its Potential Use as a Therapeutic Target to Mitigate Cisplatin-Induced Nephrotoxicity

(2010) L. M. Aleksunes et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Increased Susceptibility of Nrf2-Null Mice to 1-Bromopropane–Induced Hepatotoxicity

(2010) Fang Liu et al.   TOXICOLOGICAL SCIENCES

In vitro evaluation of the toxicity induced by nickel soluble and particulate forms in human airway epithelial cells

(2010) Efrat Forti et al.   TOXICOLOGY IN VITRO

Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity

(2010) Anja Wilmes et al.   TOXICOLOGY IN VITRO

Molecular Mechanism of Ochratoxin A Transport in the Kidney

(2010) Naohiko Anzai et al.   Toxins

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice

(2009) Melinda S. Yates et al.   CARCINOGENESIS

Characterisation of Cadmium Chloride Induced Molecular and Functional Alterations in Airway Epithelial Cells

(2009) Efrat Forti et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex

(2009) Vilim Žlender et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effect of ochratoxin A on redox-regulated transcription factors, antioxidant enzymes and glutathione-S-transferase in cultured kidney tubulus cells

(2008) C. Boesch-Saadatmandi et al.   FOOD AND CHEMICAL TOXICOLOGY

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

(2008) C.J. Harvey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ochratoxin A impairs Nrf2-dependent gene expression in porcine kidney tubulus cells

(2008) C. Boesch-Saadatmandi et al.   JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

The Nrf2–Keap1 defence pathway: Role in protection against drug-induced toxicity

(2007) Ian M. Copple et al.   TOXICOLOGY